Abstract：
:This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known antidepressant fluoxetine (prozac). The MDR phenomena and mechanisms are discussed, including the roles of ABC transporters as MDR-pumps and the potential involvement of cancer stem cells. The three generations of MDR reversal agents (chemosensitizers) are reviewed, introducing the concept of single-pump and multi-pump agents. The current status of chemosensitization is summarized, pointing-out the need for additional agents and outlining experimental criteria for testing novel candidates. Major in vitro and in vivo findings are summarized showing that fluoxetine is a chemosensitizer of the multi-pump type, and proposing it be considered a fourth-generation chemosensitizer. In concluding, we contemplate future prospects of modulating MDR in the clinic.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Peer D,Margalit Rdoi
10.1016/j.canlet.2005.06.003keywords:
subject
Has Abstractpub_date
2006-06-18 00:00:00pages
180-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00548-3journal_volume
237pub_type
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