Promotion pattern and tumour types in two-stage rat skin carcinogenesis.

abstract：:Glucose and glutamine metabolism of two microregions of human infiltrating ductile breast cancer, the center and the periphery, was studied and the results were compared with those of healthy mammary glands. In general, the activities of glycolytic enzymes and of phosphate-dependent glutaminase were as follows: center...

journal_title：Cancer letters

authors： dos Santos MA,Borges JB,de Almeida DC,Curi R

更新日期：2004-12-28 00:00:00

abstract：:Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and the approaches to test MDR have been discovered, yet not fully understood. This review covers the in vivo and in vitro approaches for the detection of MDR in the laboratory and the mechanisms ...

journal_title：Cancer letters

authors： Wu Q,Yang Z,Nie Y,Shi Y,Fan D

更新日期：2014-06-01 00:00:00

abstract：:To determine the genotoxic risk associated with therapeutic exposure to 131I, we studied the presence of micronuclei (MN) in binucleated peripheral blood lymphocytes of a group of 22 women, patients of thyroid cancer, who received 131I sodium iodide orally as an adjuvant after total thyroidectomy. The cytogenetic stud...

journal_title：Cancer letters

authors： Gutiérrez S,Carbonell E,Galofréa P,Xamena N,Creus A,Marcos R

更新日期：1995-05-08 00:00:00

abstract：:Approximately 25% of stage III colorectal cancer patients do not benefit from standard adjuvant chemotherapies. To identify biomarkers for nonresponders, fresh-frozen tissues of 19 nonresponders and 16 responders were analyzed with gene expression and microRNA arrays. Fifty-nine genes and 17 miRNAs were differentially...

journal_title：Cancer letters

authors： Dou R,Deng Y,Huang L,Fu S,Tan S,Wang L,Lian L,Fang L,Fan X,Jin G,Liu H,Wang J

更新日期：2013-08-09 00:00:00

abstract：:As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction po...

journal_title：Cancer letters

authors： Koyama J,Inoue M,Morita I,Kobayashi N,Osakai T,Nishino H,Tokuda H

更新日期：2006-09-28 00:00:00

abstract：:Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas ...

journal_title：Cancer letters

authors： Roomi MW,Vincent SH,Farber E,Muller-Eberhard U

更新日期：1988-12-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...

journal_title：Cancer letters

authors： Lv W,Chen N,Lin Y,Ma H,Ruan Y,Li Z,Li X,Pan X,Tian X

更新日期：2016-06-01 00:00:00

abstract：:A single administration of enantiomerically pure 11,12-dihydrodiols of dibenzo[a,l]pyrene (DB[a,l]P) on the back of NMRI mice and subsequent chronic treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) (initiation/promotion assay) revealed strikingly different carcinogenic activities of both enantiomers. Tumor-in...

journal_title：Cancer letters

authors： Luch A,Friesel H,Seidel A,Platt KL

更新日期：1999-03-01 00:00:00

abstract：:Fifteen samples from 11 patients suffering from chronic lymphocytic leukaemia (CLL; 5 untreated, 6 chemotherapeutically treated) were analysed for their individual gene expression of the multidrug resistance (MDR) associated genes encoding mdr1/P-glycoprotein, mrp, and topoisomerase II alpha/beta-isoenzymes by a compl...

journal_title：Cancer letters

authors： Beck J,Niethammer D,Gekeler V

更新日期：1994-10-28 00:00:00

abstract：:Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological ...

journal_title：Cancer letters

authors： Verkerk R,van der Gaag MS,Dekker M,Jongen WM

更新日期：1997-03-19 00:00:00

abstract：:Doxycycline has been found to induce apoptosis and to inhibit the growth of a variety of tumor cells, in addition to its use as an antibiotic. However, the mechanism of its actions, especially at the molecular level, remains unknown and needs to be resolved. A crucial step possibly lies in the early period of doxycycl...

journal_title：Cancer letters

authors： Sun T,Zhao N,Ni CS,Zhao XL,Zhang WZ,Su X,Zhang DF,Gu Q,Sun BC

更新日期：2009-11-28 00:00:00

abstract：:The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...

journal_title：Cancer letters

authors： Hsu B,Marin MC,McDonnell TJ

更新日期：1995-07-20 00:00:00

abstract：:We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-alpha and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was d...

journal_title：Cancer letters

authors： Zhang ZJ,Wang JL,Muhr C,Smits A

更新日期：1996-02-27 00:00:00

abstract：:Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis...

journal_title：Cancer letters

authors： Qiao J,Kang J,Ko TC,Evers BM,Chung DH

更新日期：2006-10-28 00:00:00

abstract：:Pancreatic cancer is the most lethal tumor. CA125 (gene symbol MUC16) is an important serum marker for pancreatic cancer diagnosis and treatment. High serum CA125 is related to metabolic tumor burden and poor prognosis. The circulating Treg subset is another independent prognostic factor for pancreatic cancer. Our unp...

journal_title：Cancer letters

authors： Fan K,Yang C,Fan Z,Huang Q,Zhang Y,Cheng H,Jin K,Lu Y,Wang Z,Luo G,Yu X,Liu C

更新日期：2018-04-01 00:00:00

abstract：:The present study was undertaken to determine the kinetics of DNA synthesis and expression of cell cycle dependent proto-oncogenes in response to two types of cell proliferative stimuli in male Wistar rat liver. The peak of DNA synthesis was approximately 24 h after a compensatory cell proliferative stimulus induced b...

journal_title：Cancer letters

authors： Coni P,Bignone FA,Pichiri G,Ledda-Columbano GM,Columbano A,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1989-09-15 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive primary brain tumor with great invasiveness and resistance to chemotherapy, which presents a treatment challenge. In this study, we investigated the antitumor effect of Cedrol, a sesquiterpene alcohol isolated from Cedrus atlantica, against GBM cells in vitro and in...

journal_title：Cancer letters

authors： Chang KF,Huang XF,Chang JT,Huang YC,Weng JC,Tsai NM

更新日期：2020-12-28 00:00:00

abstract：:Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts an...

journal_title：Cancer letters

authors： Lühr I,Friedl A,Overath T,Tholey A,Kunze T,Hilpert F,Sebens S,Arnold N,Rösel F,Oberg HH,Maass N,Mundhenke C,Jonat W,Bauer M

更新日期：2012-12-28 00:00:00

abstract：:We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a...

journal_title：Cancer letters

authors： Jiao L,Hassan MM,Bondy ML,Abbruzzese JL,Evans DB,Li D

更新日期：2007-01-08 00:00:00

abstract：:The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in ...

journal_title：Cancer letters

authors： Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Y

更新日期：2001-08-28 00:00:00

abstract：:Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...

journal_title：Cancer letters

authors： Jeong SJ,Itokawa T,Shibuya M,Kuwano M,Ono M,Higuchi R,Miyamoto T

更新日期：2002-12-10 00:00:00

abstract：:Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...

journal_title：Cancer letters

authors： Perin-Roussel O,Croisy A,Ekert B,Zajdela F

更新日期：1984-04-01 00:00:00

abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...

journal_title：Cancer letters

authors： Parfett CL,Pilon R

更新日期：1993-07-30 00:00:00

abstract：:Mining and mineral processing are important industries in the United States. A large number of workers are potentially exposed to silica during mining and to glass fibers during manufacturing. There is a concern regarding lung cancer risk among workers exposed to silica and glass fibers. Our previous studies showed th...

journal_title：Cancer letters

authors： Gao H,Brick J,Ong S,Miller M,Whong WZ,Ong T

更新日期：1997-01-15 00:00:00

abstract：:Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I-IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting C...

journal_title：Cancer letters

authors： Bancher-Todesca D,Rosen A,Graf A,Wasicky R,Hohlagschwandtner M,Rebhandl W,Heinze G,Breitenecker G,Gitsch G,Obermair A

更新日期：1999-07-01 00:00:00

abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

journal_title：Cancer letters

authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

更新日期：1982-05-01 00:00:00

abstract：:Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there were relatively few...

journal_title：Cancer letters

authors： Ramesh G,Das UN

更新日期：1998-01-30 00:00:00

abstract：:The alkylation of hamster liver, lung and pancreas DNA by [1-14C]- and [2,3-14C]N-nitrosobis (2-oxopropyl) amine (BOP) has been examined. The specific activity of pancreas DNA after [2,3-14C]BOP administration was only 2% of that when [1-14C]BOP was given. 7-Methylguanine, but not O-6-methylguanine, was found in hydro...

journal_title：Cancer letters

authors： Lawson TA,Gingell R,Nagel D,Hines LA,Ross A

更新日期：1981-01-01 00:00:00

abstract：:Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patien...

journal_title：Cancer letters

authors： Kerr SH,Kerr DJ

更新日期：2009-12-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) inhibits proliferation of cancer. However, the effects of ATRA on scattering and invasion of pancreatic cancer cells remain unknown. Also, the effects of ATRA on c-Met expression in pancreatic cancer have never been addressed so far. The effects of ATRA on a pancreatic cancer cell line, ...

journal_title：Cancer letters

authors： Leelawat K,Ohuchida K,Mizumoto K,Mahidol C,Tanaka M

更新日期：2005-06-28 00:00:00