Abstract:
:As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction potentials and number of the hydroxyl groups and the inhibitory effects of the hydroxylated emodin derivatives on Epstein-Barr virus early antigen activation. The electronic properties, i.e. LUMO energy and atomic charges of carbon at the 9-position (C(9)) and oxygen at the 11-position (O(11)), may also be useful for estimating the inhibitory effect on EBV-EA activation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Koyama J,Inoue M,Morita I,Kobayashi N,Osakai T,Nishino H,Tokuda Hdoi
10.1016/j.canlet.2005.10.043keywords:
subject
Has Abstractpub_date
2006-09-28 00:00:00pages
263-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00947-Xjournal_volume
241pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::CD271, known as a neurotrophin receptor, is expressed in various cancers such as hypopharyngeal cancer (HPC) and melanoma. We recently reported that CD271 is a cancer-stem-cell biomarker of HPC, and that its expression is essential for cancer-cell proliferation and is correlated with a poor prognosis in this disease. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.07.011
更新日期:2019-10-01 00:00:00
abstract::Autophagy is a membrane process that results in the transporting of cellular contents to lysosomes for degradation. Autophagic cell death is another way of programed cell death called type II PCD, which has complicated connection with apoptosis, both of these two types of cell death play an important role in tumor dev...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.06.039
更新日期:2010-02-01 00:00:00
abstract::Oxidative stress is implicated in the etiology of cancer, hence compounds that alleviate oxidative stress by inducing enzymes that defend against free radical damage might be useful as cancer chemopreventives. Glutathione S-transferase (GST) has been suggested to be a candidate for a critical enzyme in protecting cell...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00368-2
更新日期:2000-08-11 00:00:00
abstract::Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90079-8
更新日期:1980-09-01 00:00:00
abstract::Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Hypoxia induces metabolic alterations in cancer, thereby promoting aggressive malignancy and metastasis. While previous efforts largely focused on adaptive responses in glucose and glutamine metabolism, recent studies have begun to yield i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.06.013
更新日期:2020-11-28 00:00:00
abstract::Tyrosine kinase inhibitor (TKI) treatment is the first-line therapy for non-small cell lung cancer (NSCLC) caused by activating mutations of epidermal growth factor receptor (EGFR). However, acquired resistance to EGFR-TKI occurs almost inevitably. Aberrant activation of proto-oncogene MET has been known to confer EGF...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.09.003
更新日期:2020-12-28 00:00:00
abstract::Arginine deiminase (ADI), isolated from Mycoplasma cell extracts, has been suggested to inhibit endothelial cell growth in vitro. However, anti-angiogenic activity by ADI has not yet been demonstrated. In this study, we investigated the in vitro effect of recombinant ADI (rADI) on the growth, migration, and tube forma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00793-5
更新日期:2002-09-26 00:00:00
abstract::Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we us...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.06.017
更新日期:2016-09-28 00:00:00
abstract::Frequent occurrence of chromosome 22q deletions in lung cancer indicates the presence of a tumor suppressor gene on this chromosome arm. The hSNF5/INI1 gene at chromosome 22q11.2 has recently been shown to act as a tumor suppressor in rhabdoid tumors. To investigate whether the hSNF5/INI1 gene located on chromosome 22...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00342-6
更新日期:2000-05-29 00:00:00
abstract::Standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC), nab-paclitaxel (NPT) plus gemcitabine (Gem), has led to an average survival of 8.5 months. Presently, no therapeutics exist that effectively target the KRAS oncogene, activated in 95% of PDACs, but alternative strategies focus on inhibition of downstre...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.05.037
更新日期:2019-09-10 00:00:00
abstract::Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90112-6
更新日期:1986-08-01 00:00:00
abstract::As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.030
更新日期:2016-12-28 00:00:00
abstract::Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.08.007
更新日期:2015-12-01 00:00:00
abstract::Polyphenolic antioxidants protected against Al-phthalocyanine tetrasulfonate-sensitized photohemolysis of human erythrocytes. A quantitative structure-activity relationship has been obtained to describe the protective effects of di- and trihydroxybenzenes: log cI(50) (microM)=(1.8620+/-1.5565)+(3.6366+/-2.8245) E(1)(7...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00469-9
更新日期:2000-08-31 00:00:00
abstract::We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00505-3
更新日期:1998-03-13 00:00:00
abstract::Neuroblastoma (NB) is a solid childhood tumour that exhibits heterogeneous biological and clinical phenotypes. Multiple drug resistance marks a major complication especially in high-risk patients with advanced tumour stages and specific genetic aberrations, such as MYCN amplification and lp deletion. As an approach to...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.09.010
更新日期:2007-05-18 00:00:00
abstract::The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.040
更新日期:2017-02-01 00:00:00
abstract::The aim of the study was to demonstrate the role of parathyroid hormone related protein (PTHrP) in stimulating aldo-keto reductase (AKR) 1C3 expression in prostate cancer (CaP) cells. CaP cell proliferation and resistance to apoptosis was increased by PTHrP transfection. Conversely, reducing AKR1C3 expression by siRNA...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.02.027
更新日期:2011-07-01 00:00:00
abstract::Patients with pancreatic adenocarcinoma (PDAC) have a 5-year survival rate of 8%, the lowest of any cancer in the United States. Traditional chemotherapeutic regimens, such as gemcitabine- and fluorouracil-based regimens, often only prolong survival by months. Effective precision targeted therapy is therefore urgently...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.08.002
更新日期:2020-10-28 00:00:00
abstract::This study was designed to investigate the influence of neonatal selenium (an anticarcinogenic agent) exposure on spontaneous liver tumor formation in adult mice. Pregnant CBA mice were administered selenium during the last week of pregnancy and for ten days following parturition. Selenium significantly reduced the in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00862-x
更新日期:2002-05-08 00:00:00
abstract::Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04336-4
更新日期:1996-10-01 00:00:00
abstract::Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.01.007
更新日期:2014-05-01 00:00:00
abstract::Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.10.027
更新日期:2005-06-01 00:00:00
abstract::Aurora-A (Aur-A) is a centrosome-associated serine/threonine kinase that is overexpressed in various cancers and potentially correlated with chemoresistance. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell deat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.05.009
更新日期:2010-11-28 00:00:00
abstract::Fluorescence-activated cell sorting (FACS) based on the surface marker CD133 is the most common method for isolating glioma stem cells (GSCs) from heterogeneous glioma cell populations. Optimization of this method will have profound implications for the future of GSC research. Five commonly used digestion reagents, Li...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.04.022
更新日期:2016-07-10 00:00:00
abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor in Chief. The term miR-143 has been used instead of the term miR-143* in the introduction and discussion which is misleading...
journal_title:Cancer letters
pub_type: 杂志文章,收录出版
doi:10.1016/j.canlet.2016.01.023
更新日期:2016-04-01 00:00:00
abstract::Patients with Her2-positive breast cancer exhibit de novo resistance or develop acquired resistance in less than one year after Her2 targeting treatment, but the mechanism is not fully elucidated. Compensatory pathways such as the IGF-1R/IRS-1 pathway, are activated, leading to aberrant enhanced PI3K/Akt/mTOR pathway ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.08.008
更新日期:2019-11-01 00:00:00
abstract::Although mutations of p53 and KRAS and activation of NF-κB signaling have been highly associated with chemoresistance and tumorigenesis of lung cancer, the interactive mechanisms between two of p53, KRAS, and NF-κB are elusive. In the present study, we first observed that blocking of NF-κB function in KRAS mutant A549...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.003
更新日期:2015-02-28 00:00:00
abstract::Cancer cells are shed into the blood stream and are exposed to hemodynamic shear stress during metastasis. It has been shown that shear stress can destroy circulating tumor cells (CTCs) both in vitro and in vivo. However, it remains unclear whether shear stress can modulate the properties and functions of tumor cells ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.12.001
更新日期:2017-03-01 00:00:00
abstract::One of the most promising substances used in photodynamic therapy (PDT) is 5-aminolevulinic acid (ALA), which induces endogenous synthesis and accumulation of porphyrins in malignant cells. In this paper we have shown that both topical and intratumoral administration of ALA in a subcutaneously implanted mammary carcin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00079-8
更新日期:1999-07-01 00:00:00