Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer.

Abstract:

:This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 antigen and CEA expression in colon cancer, and CEA expression in rectal cancer that was limited to the metastatic lymph nodes. The immunohistochemical scores were higher in short-term survivors. Our data suggest that the characteristics of metastatic lymph nodes are important as a predictor of the aggressiveness of tumor behavior and that the expression of Ki-67 antigen or CEA there may be a useful indicators of patients' survival in Dukes' C colorectal cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Ishida H,Miwa H,Tatsuta M,Masutani S,Imamura H,Shimizu J,Ezumi K,Kato H,Kawasaki T,Furukawa H,Kawakami H

doi

10.1016/j.canlet.2003.10.032

keywords:

subject

Has Abstract

pub_date

2004-04-15 00:00:00

pages

109-15

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304383503007481

journal_volume

207

pub_type

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