Abstract：
:Castration is the standard therapeutic treatment for advanced prostate cancer but with limited benefit due to the profound relapse and metastasis. Activation of inflammatory signaling pathway and initiation of epithelial-mesenchymal transition (EMT) are closely related to drug resistance, tumor relapseas well as metastasis. In this study, we demonstrated that metformin is capable of inhibiting prostate cancer cell migration and invasion by repressing EMT evidenced by downregulating the mesenchymal markers N-cadherin, Vimentin, and Twist and upregulating the epithelium E-cadherin. These effects have also been observed in our animal model as well as prostate cancer patients. In addition, we showed the effects of metformin on the expression of genes involved in EMT through repressing the levels of COX2, PGE2 and phosphorylated STAT3. Furthermore, inactivating COX2 abolishes metformin's regulatory effects and exogenously administered PGE2 is capable of enhancing STAT3 phosphorylation and expression of EMT biomarker. We propose that metformin represses prostate cancer EMT and metastasis through targeting the COX2/PGE2/STAT3 axis. These findings suggest that metformin by itself or in combination with other anticancer drugs could be used as an anti-metastasis therapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Tong D,Liu Q,Liu G,Xu J,Lan W,Jiang Y,Xiao H,Zhang D,Jiang Jdoi
10.1016/j.canlet.2016.12.031subject
Has Abstractpub_date
2017-03-28 00:00:00pages
23-32eissn
0304-3835issn
1872-7980pii
S0304-3835(16)30801-1journal_volume
389pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulenc...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.11.016
更新日期：2009-09-08 00:00:00
abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90134-h
更新日期：1992-12-24 00:00:00
abstract：:The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03688-s
更新日期：1995-03-02 00:00:00
abstract：:BRAFV600- and MEK1/2-targeting therapies rarely produce durable response in melanoma patients. We investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib (Braftovi), a recently FDA-approved BRAFV600 inhibitor. Drug-naïve cell lines (i) did no...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.11.036
更新日期：2021-02-28 00:00:00
abstract：:Liposome encapsulation of anticancer agents results in reduced side effects of the entrapped drug and improved therapeutic efficacy. The external surface of the lipidic envelope can be coupled with antibodies directed against tumor-associated antigens. The resulting immunoliposomes allow to increase the therapeutic in...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2004.11.065
更新日期：2005-10-18 00:00:00
abstract：:Ashwagandha, also called as "Queen of Ayurveda" and "Indian ginseng", is a commonly used plant in Indian traditional medicine, Ayurveda. Its roots have been used as herb remedy to treat a variety of ailments and to promote general wellness. However, scientific evidence to its effects is limited to only a small number ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.11.037
更新日期：2008-04-08 00:00:00
abstract：:Gene-silencing with targeted siRNAs has great potential as a therapeutic approach for various diseases including cancer. However, intracellular delivery of siRNA is challenging. We used bovine milk exosomes as a novel system for siRNA delivery. First, we demonstrated that exosomes can deliver endogenous RNA payloads i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.02.011
更新日期：2019-05-01 00:00:00
abstract：:Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04346-7
更新日期：1996-10-01 00:00:00
abstract：:Polyphenolic antioxidants protected against Al-phthalocyanine tetrasulfonate-sensitized photohemolysis of human erythrocytes. A quantitative structure-activity relationship has been obtained to describe the protective effects of di- and trihydroxybenzenes: log cI(50) (microM)=(1.8620+/-1.5565)+(3.6366+/-2.8245) E(1)(7...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00469-9
更新日期：2000-08-31 00:00:00
abstract：:We examined the antitumor effect and safety of the adenovirus-mediated expression of antisense K-ras RNA in two peritoneal dissemination models of pancreatic cancer. First, we found that the infection of an adenovirus vector expressing antisense human K-ras RNA (AxCA-AS) induced significant apoptosis in vitro in human...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.08.015
更新日期：2005-01-31 00:00:00
abstract：:Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.09.012
更新日期：2016-12-01 00:00:00
abstract：:A tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. Genomic changes could be of potential use in the diagnosis and prognosis of pre-invasive squamous head and neck carcinoma (HNSCC) lesions and as markers for cancer risk assessment. Studies of sequential molecu...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2012.02.018
更新日期：2014-01-28 00:00:00
abstract：:Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a liga...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.03.005
更新日期：2010-09-28 00:00:00
abstract：:The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellular lineages. As tumor ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.04.019
更新日期：2013-11-28 00:00:00
abstract：:Calcium-stimulated, phospholipid dependent protein kinase C activity was found in cytosolic extracts of the epidermis of SENCAR, C57BL/6 and Ha/ICR mice. The enzymes were partially purified by DEAE-cellulose chromatography. There were no significant differences between the 3 strains in basal protein kinase C activity....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90161-2
更新日期：1985-11-01 00:00:00
abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00713-9
更新日期：2003-03-31 00:00:00
abstract：:We assessed whether current therapies could lead to hematogenous dissemination of malignant hepatocytes in hepatocellular carcinoma (HCC) patients using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) for alpha-fetoprotein (afp) and albumin (alb) mRNAs. We analyzed 137 peripheral blood sampl...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00455-4
更新日期：2001-06-26 00:00:00
abstract：:Sprague-Dawley rats were injected weekly with either 1,2-dimethylhydrazine (DMH) or methylazoxymethanol acetate (MAM). Addition of 4 ppm selenium (sodium selenite) in the drinking water reduced the number of rats developing DMH-induced colon tumors from 13 to 6 groups of 15 each. The total number of tumors observed in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(77)80002-5
更新日期：1977-01-01 00:00:00
abstract：:We investigated the relative effectiveness of four differentiation-inducing chemicals to induce a more normal or benign phenotype in the human colon cancer cell lines Moser and HT29. The differentiation-inducing capability of all-trans retinoic acid (ATRA), difluoromethylornithine (DFMO), sodium butyrate (NaB) and sod...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00242-0
更新日期：1998-12-11 00:00:00
abstract：:Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.07.044
更新日期：2016-09-28 00:00:00
abstract：:Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal tr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90193-7
更新日期：1994-06-30 00:00:00
abstract：:Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.05.012
更新日期：2016-08-10 00:00:00
abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2020.01.001
更新日期：2020-03-31 00:00:00
abstract：:Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2018.03.040
更新日期：2018-07-01 00:00:00
abstract：:Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables a...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.04.018
更新日期：2008-10-08 00:00:00
abstract：:A common germline polymorphism of p53 gene produces an Arginine to Proline change at aminoacid position 72. The resulting codon 72 variants have been reported associated with tumor susceptibility since they reduce p53 ability to activate apoptosis. Codon 72 polymorphism may play a role in subside vulnerability to diff...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.01.016
更新日期：2004-07-16 00:00:00
abstract：:Mammaglobin B is a recently-isolated gene speculated to belong to the uteroglobin gene family and is overexpressed in primary breast cancers. We investigated mammaglobin B mRNA expression in various cancers of the digestive system. Given the absence of mammaglobin B expression in normal lymph nodes, we also assessed t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00378-x
更新日期：2000-03-13 00:00:00
abstract：:We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [(3)H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00549-8
更新日期：2000-11-10 00:00:00
abstract：:Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.12.020
更新日期：2014-04-28 00:00:00
abstract：:Hypoxia causes upregulation of vascular endothelial growth factor (VEGF) which is a key regulator in tumor angiogenesis and essential for the proliferation of endothelial cells. Endothelial cells have been described to accumulate radiotracers like (18)F-FDG. However, the contribution of radiotracer uptake by endotheli...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.02.016
更新日期：2007-08-28 00:00:00
