Abstract:
:Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a lesser extent than aldehyde dehydrogenase, aldehyde reductase and glutathione-S-transferase also increase during carcinogenesis. Of the latter two enzymes, aldehyde reductase increases more markedly in a progressive fashion during the months of development of nodules and hepatoma. The increase of enzymes able to metabolize 4-hydroxynonenal, as well as other aldehydes, is certainly important in protecting tumour cells against cytotoxic effect of aldehydes.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Canuto RA,Muzio G,Maggiora M,Biocca ME,Dianzani MUdoi
10.1016/0304-3835(93)90144-xsubject
Has Abstractpub_date
1993-02-01 00:00:00pages
177-83issue
2-3eissn
0304-3835issn
1872-7980pii
0304-3835(93)90144-Xjournal_volume
68pub_type
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