Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake.


:The influence of grapefruit juice intake on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced colon DNA damage was examined using comet assay in F344 rats given 60 mg/kg of PhIP by gavage. F344 rats allowed free access to grapefruit juice for 5 days experienced clearly reduced DNA damage in the colon to a 40% level of control rats. The suppression of PhIP-induced colon DNA damage depended on the grapefruit juice concentrations. The serum concentration of PhIP was compared between grapefruit juice-pretreated and non-pretreated rats, but showed no significant difference in the areas under their concentration-time curves, peak values and half lives of PhIP. Furthermore, no obvious difference was found in the liver capacity for mutagenic activation of PhIP in Ames assay between grapefruit juice-pretreated and non-pretreated rats. These results suggest that grapefruit juice suppresses PhIP-induced colon DNA damage by a mechanism independent of PhIP absorption in the intestine.


Cancer Lett


Cancer letters


Miyata M,Takano H,Takahashi K,Sasaki YF,Yamazoe Y





Has Abstract


2002-09-08 00:00:00














  • Pseudogene PDIA3P1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway.

    abstract::Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study,...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kong Y,Zhang L,Huang Y,He T,Zhang L,Zhao X,Zhou X,Zhou D,Yan Y,Zhou J,Xie H,Zhou L,Zheng S,Wang W

    更新日期:2017-10-28 00:00:00

  • Influence of dietary iron overload on cell proliferation and intestinal tumorigenesis in mice.

    abstract::Iron-enriched diets caused an increase of tumor rate in two models of dimethylhydrazine(DMH)-induced colon tumorigenesis in mice. The effect was independent of the time the iron-diet was fed, i.e. during DMH-treatment or following the DMH-treatment period. The increase of tumor rate depended on the iron concentration ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Siegers CP,Bumann D,Trepkau HD,Schadwinkel B,Baretton G

    更新日期:1992-08-31 00:00:00

  • Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity.

    abstract::Starting with an extract derived from the bark of Mundulea sericea Willd. (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lee SK,Luyengi L,Gerhäuser C,Mar W,Lee K,Mehta RG,Kinghorn AD,Pezzuto JM

    更新日期:1999-02-08 00:00:00

  • Suppression of heat-induced hsp72 accumulation by cisplatin in human glioblastoma cells.

    abstract::The accumulation of the inducible hsp72 (72-kDa heat shock protein) after hyperthermia and/or cisplatin treatment in human glioblastoma cell line (A-172) was studied by Western blot analysis. The level of hsp72 increased to eight-fold 10 h after hyperthermia alone (44 degrees C for 20 min, D50) and to three-fold 10 h ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Matsumoto H,Hayashi S,Shioura H,Ohtsubo T,Ohnishi T,Kano E

    更新日期:1996-12-20 00:00:00

  • An M(r) 7-kDa membrane protein overexpressed in human multidrug-resistant ovarian cancer cells.

    abstract::We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods....

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yang X,Pagé M

    更新日期:1995-01-27 00:00:00

  • Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation.

    abstract::Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yit CC,Das NP

    更新日期:1994-07-15 00:00:00

  • Chromatin structure of human chromosomal fragile sites.

    abstract::Cytological appearance of fragile sites as non-staining gaps in metaphase chromosomes suggests an abnormality in chromatin structure. Studies of fragile sites at three levels of chromosome organization: (1) examining the ability of DNA derived from fragile sites to form nucleosomes-the basic structural element of chro...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Wang YH

    更新日期:2006-01-28 00:00:00

  • Residential radon and small cell lung cancer. A systematic review.

    abstract::Residential radon exposure is considered the second cause of lung cancer and the first in never smokers. Nevertheless, the association between the different histological types of lung cancer and radon is not completely clear, and radon effect on small cell lung cancer is not completely understood. We aim to asses the ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Rodríguez-Martínez Á,Torres-Durán M,Barros-Dios JM,Ruano-Ravina A

    更新日期:2018-07-10 00:00:00

  • Inhibitory effects of Rooibos tea, Aspalathus linealis, on X-ray-induced C3H10T1/2 cell transformation.

    abstract::Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Komatsu K,Kator K,Mitsuda Y,Mine M,Okumura Y

    更新日期:1994-02-28 00:00:00

  • The role of membrane transporters in drug delivery to brain tumors.

    abstract::Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Nies AT

    更新日期:2007-08-28 00:00:00

  • The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.

    abstract::We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jiao L,Hassan MM,Bondy ML,Abbruzzese JL,Evans DB,Li D

    更新日期:2007-01-08 00:00:00

  • Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression.

    abstract::We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Al-Salihi MA,Terrece Pearman A,Doan T,Reichert EC,Rosenberg DW,Prescott SM,Stafforini DM,Topham MK

    更新日期:2009-01-18 00:00:00

  • Chromosomal imbalances in sporadic neuroendocrine tumours of the thymus.

    abstract::Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Rieker RJ,Aulmann S,Penzel R,Schnabel PA,Blaeker H,Esposito I,Morresi-Hauf A,Otto HF,Hecker E,Dienemann H,Schirmacher P,Mechtersheimer G

    更新日期:2005-06-01 00:00:00

  • Relationship between CD44 expression and differentiation of human prostate adenocarcinomas.

    abstract::It is well documented that CD44 plays an important role in tumor metastasis. We investigated whether there is a correlation between the expression of its isoforms in prostate cancer cells and patient prognosis using 72 cases with biopsy specimens. Immunohistochemistry demonstrated expression of CD44H (68.1%), v6 (36.1...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Takahashi S,Kimoto N,Orita S,Cui L,Sakakibara M,Shirai T

    更新日期:1998-07-03 00:00:00

  • Effect of glucose administration on hamster liver S9-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and aflatoxin B1.

    abstract::Hamster liver S9 prepared from control animals and animals given 30% glucose in drinking water 48 h before killing was used in studies of benzo[a]pyrene (BaP) and aflatoxin (AFB1)-induced mutagenesis, metabolism of BaP and AFB1, and metabolite binding to calf thymus DNA. BAP-induced mutagenesis in Salmonella typhimuri...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Rubano DC,Teel RW,Strother A

    更新日期:1990-07-16 00:00:00

  • Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone): an irreversible inhibitor for both ornithine and S-adenosylmethionine decarboxylases and its effect on human lymphoid leukemia Molt 4B cells.

    abstract::Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells. The compound irreversibly inhibited ornithine and S-adenosylmethione decarboxylases. This inhibitio...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hibasami H,Sakurai M,Maekawa S,Murata T,Nakashima K

    更新日期:1988-03-01 00:00:00

  • Effect of continuous light on the incidence of 9,10-dimethyl-1,2-benzanthracene induced mammary tumors in female Holtzman rats.

    abstract::The pineal has been recently implicated in mammary tumorigenesis. Effect of physiological pinealectomy brought about by subjecting female Holtzman rats to permanent lighting (24 h/day) from birth was studied on the incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary tumors. The incidence of adenocarci...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kothari LS,Shah PN,Mhatre MC

    更新日期:1982-09-01 00:00:00

  • The origin and role of blood-borne monocytes in rats with a transplanted myelogenous leukaemia.

    abstract::The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from tha...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Gauci CL,Wrathmell A,Alexander P

    更新日期:1975-09-01 00:00:00

  • Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.

    abstract::Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a less...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Canuto RA,Muzio G,Maggiora M,Biocca ME,Dianzani MU

    更新日期:1993-02-01 00:00:00

  • The cyclin-dependent kinase inhibitor p21(cip1/waf1) enhances the cytotoxicity of ganciclovir in HSV-tk transfected ovarian carcinoma cells.

    abstract::Suicide gene therapy could be an attractive addition to the treatment of ovarian carcinomas, for which acquired chemoresistance frequently results in treatment failure. Here we show that transfection of the HSV-tk gene, followed by incubation with up to 1 mM ganciclovir fails to induce cell death in SKOV3 chemoresista...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ziller C,Lincet H,Muller CD,Staedel C,Behr JP,Poulain L

    更新日期:2004-08-20 00:00:00

  • Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation.

    abstract::Fas/APO-1/CD95, a member of the tumor necrosis factor (TNF) receptor superfamily, is a potential anti-cancer factor as it can induce apoptosis in tumor cells. However, despite the fact that many cancer cells express Fas on the membrane, some tumors such as prostate cancer display resistance to Fas-induced apoptosis. I...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Park IJ,Kim MJ,Park OJ,Park MG,Choe W,Kang I,Kim SS,Ha J

    更新日期:2010-12-01 00:00:00

  • Cellular retinoid-binding proteins in cultured human and mouse myeloid leukemia cells.

    abstract::Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Takenaga K,Honma Y,Hozumi M

    更新日期:1981-06-01 00:00:00

  • NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate.

    abstract::Despite recent improvements in chemotherapy and surgery, the problem of non-response osteosarcoma to chemotherapy remains, and is a parameter that is critical for prognosis. The present work investigated the therapeutic value of NVP-BEZ235, a dual class I PI3K/mTOR inhibitor. NVP-BEZ235 inhibited osteosarcoma cell pro...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Gobin B,Battaglia S,Lanel R,Chesneau J,Amiaud J,Rédini F,Ory B,Heymann D

    更新日期:2014-03-28 00:00:00

  • Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors.

    abstract::Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nicklin SA,Dishart KL,Buening H,Reynolds PN,Hallek M,Nemerow GR,Von Seggern DJ,Baker AH

    更新日期:2003-11-25 00:00:00

  • Inhibitory effect of caloric restriction on tumorigenicity induced by 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in the CD1 newborn mouse bioassay.

    abstract::The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the ca...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Von Tungeln LS,Bucci TJ,Hart RW,Kadlubar FF,Fu PP

    更新日期:1996-07-12 00:00:00

  • Alterations in repair of alkylating agent-induced DNA damage in polyamine-depleted human cells.

    abstract::Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Snyder RD,Bhatt S

    更新日期:1993-08-16 00:00:00

  • Synergistic inhibitory effects of transplatin and beta-hydroxyisovalerylshikon on carcinoma A431 cells involve epidermal growth factor receptor.

    abstract::Treatment of human epidermoid carcinoma A431 cells with transplatin (trans-DDP) and beta-hydroxyisovalerylshikon (beta-HIVS) together had a strong inhibitory effect on A431 cells. By contrast, trans-DDP and beta-HIVS by themselves, at the same respective concentrations, had practically no effect. The tyrosine kinase a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Xu Y,Nakajo S,Nakaya K

    更新日期:2002-12-15 00:00:00

  • Clastogenic and cytotoxic effects of spermine oxidation products in mouse lymphoma L5178Y cells.

    abstract::Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Bouzyk E,Rosiek O

    更新日期:1988-02-01 00:00:00

  • Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies.

    abstract::Monoclonal antibodies were produced and characterized in order to allow the monitoring of the urinary excretion of six modified nucleosides. The specificity of each antibody was determined and competitive solid-phase enzyme-linked immunoassays were designed, the sensitivity of which lay in the pmol range. Detection an...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Reynaud C,Bruno C,Boullanger P,Grange J,Barbesti S,Niveleau A

    更新日期:1992-01-31 00:00:00

  • Association of inhibition of cell growth by O-phospho-L-tyrosine with decreased tyrosine phosphorylation.

    abstract::We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Mishra S,Hamburger AW

    更新日期:1996-04-19 00:00:00