Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse.


:A six-month bioassay in A/J mice was conducted to test the hypothesis that chronically inhaled mainstream cigarette smoke would either induce lung cancer or promote lung carcinogenicity induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Groups of 20 female A/J mice were exposed to filtered air (FA) or cigarette smoke (CS), injected with NNK, or exposed to both CS and NNK. At 7 weeks of age, mice were injected once with NNK; 3 days later, they were exposed to CS for 6 h/day, 5 days/week, for 26 weeks at a mean 248 mg total particulate matter/m3 concentration. Animals were sacrificed 5 weeks after exposures ended for gross and histological evaluation of lung lesions. No significant differences in survival between exposure groups was observed. A biologically significant level of CS exposure was achieved as indicated by CS-induced body weight reductions, lung weight increases, and carboxyhemoglobin levels in blood of about 17%. Crude tumor incidences, as determined from gross observation of lung nodules, were similar between the CS-exposed and FA groups, and the NNK and CS + NNK groups. Incidences in either of these latter groups were greater than either the CS or FA groups. Furthermore, tumor multiplicity in tumor-bearing animals was not significantly different among any of the three groups (FA, NNK, CS + NNK) in which tumors were observed. Thus, CS exposure neither induced lung tumors nor promoted NNK-induced tumors. Because the CS exposure concentration was probably near the maximally tolerable level, longer exposures should be evaluated to potentially establish a CS-induced model of lung carcinogenesis in the A/J mouse.


Cancer Lett


Cancer letters


Finch GL,Nikula KJ,Belinsky SA,Barr EB,Stoner GD,Lechner JF




Has Abstract


1996-02-06 00:00:00














  • Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer.

    abstract::The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Pucelik B,Sułek A,Barzowska A,Dąbrowski JM

    更新日期:2020-11-01 00:00:00

  • Nelfinavir, an HIV protease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mitochondrial pathway.

    abstract::HIV protease inhibitors (HIV-PIs) are a class of antiretroviral drugs designed to target the viral protease. Strikingly, these drugs have also been reported to possess antitumor effect. In this study, we evaluated the activity of one HIV-PI, Nelfinavir, against human cervical cancer cells. We found that Nelfinavir inh...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Xiang T,Du L,Pham P,Zhu B,Jiang S

    更新日期:2015-08-01 00:00:00

  • Blood group specificity of pancreatic tumor mucin.

    abstract::N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Runge RG,Pour P

    更新日期:1980-10-01 00:00:00

  • Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells.

    abstract::Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stro...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Saijo A,Goto H,Nakano M,Mitsuhashi A,Aono Y,Hanibuchi M,Ogawa H,Uehara H,Kondo K,Nishioka Y

    更新日期:2018-05-01 00:00:00

  • Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer.

    abstract::The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs). Limited evidence indicated that it was also expressed in tissues other than thymus and spleen, while, very recently, it was identified as a suppressor gene in breast cancer. However, ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhang HY,Sun H

    更新日期:2010-01-01 00:00:00

  • Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenized female mice.

    abstract::Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wong LM,Bern HA,Jones LA,Mills KT

    更新日期:1982-11-01 00:00:00

  • Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.

    abstract::The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Altman MK,Alshamrani AA,Jia W,Nguyen HT,Fambrough JM,Tran SK,Patel MB,Hoseinzadeh P,Beedle AM,Murph MM

    更新日期:2015-12-01 00:00:00

  • Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo.

    abstract::Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetylea...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang YP,Yan J,Beger RD,Fu PP,Chou MW

    更新日期:2005-08-08 00:00:00

  • Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.

    abstract::Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood. Despite intensive multimodal therapy, nearly half of children with high-risk disease will relapse with therapy-resistant tumors. Dysregulation of MAPK pathway has been implicated in the pathogenesis of relapsed and refractory NB patient...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li H,Yu Y,Zhao Y,Wu D,Yu X,Lu J,Chen Z,Zhang H,Hu Y,Zhai Y,Su J,Aheman A,De Las Casas A,Jin J,Xu X,Shi Z,Woodfield SE,Vasudevan SA,Agarwal S,Yan Y,Yang J,Foster JH

    更新日期:2019-08-10 00:00:00

  • Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin.

    abstract::The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 microg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival wer...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jagetia GC,Nayak V

    更新日期:1996-12-20 00:00:00

  • Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4.

    abstract::Tumor-derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the exosomal miRNAs that affect cancer progression in non-small cell lung cancer (NSCLC) and identified the specific molecules involved. We identif...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kim DH,Park S,Kim H,Choi YJ,Kim SY,Sung KJ,Sung YH,Choi CM,Yun M,Yi YS,Lee CW,Kim SY,Lee JC,Rho JK

    更新日期:2020-04-10 00:00:00

  • Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma.

    abstract::This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

    更新日期:2012-01-01 00:00:00

  • Modulation of the anti-proliferative signal of interferon-alpha by tamoxifen in U937 cells.

    abstract::Several clinical protocols are attempting to utilize the combined anti-proliferative signal of interferon-alpha (INF-alpha) and tamoxifen on cancer cells. We demonstrated here that the effect of these two agents on the growth of the premacrophage U937 cells is antagonistic. This antagonistic effect is paralleled by th...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Balint E,Grimley PM,Michalic R,Aszalos A

    更新日期:1992-10-30 00:00:00

  • The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.

    abstract::Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the 32P-postlabeling assay we showed that AAI is activated by human recombinant cytochrome P450 (CYP) 1A1, CYP1A2 and NADPH:CYP reductase to species generating DNA ad...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Stiborová M,Sopko B,Hodek P,Frei E,Schmeiser HH,Hudecek J

    更新日期:2005-11-18 00:00:00

  • Apoptosis induced by retinoic acid in Hep 3B cells in vitro.

    abstract::Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kim DG,Jo BH,You KR,Ahn DS

    更新日期:1996-10-01 00:00:00

  • Mammaglobin B gene as a novel marker for lymph node micrometastasis in patients with abdominal cancers.

    abstract::Mammaglobin B is a recently-isolated gene speculated to belong to the uteroglobin gene family and is overexpressed in primary breast cancers. We investigated mammaglobin B mRNA expression in various cancers of the digestive system. Given the absence of mammaglobin B expression in normal lymph nodes, we also assessed t...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Aihara T,Fujiwara Y,Miyake Y,Okami J,Okada Y,Iwao K,Sugita Y,Tomita N,Sakon M,Shiozaki H,Monden M

    更新日期:2000-03-13 00:00:00

  • An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer.

    abstract::Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we us...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Premasekharan G,Gilbert E,Okimoto RA,Hamirani A,Lindquist KJ,Ngo VT,Roy R,Hough J,Edwards M,Paz R,Foye A,Sood R,Copren KA,Gubens M,Small EJ,Bivona TG,Collisson EA,Friedlander TW,Paris PL

    更新日期:2016-09-28 00:00:00

  • Determination of DNA topoisomerase II in newly diagnosed childhood acute lymphoblastic leukemia by immunocytochemistry and RT-PCR.

    abstract::The expression of DNA-topoisomerase II was analysed at the protein level in newly diagnosed cases of acute lymphoblastic leukemia (ALL) in children. Blast cells obtained from 81 children with untreated ALL were determined by means of immunocytochemistry. Of the ALL, 49 (60%) were positive for topoisomerase II and 32 (...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Stammler G,Sauerbrey A,Volm M

    更新日期:1994-09-15 00:00:00

  • Bad phosphorylation as a target of inhibition in oncology.

    abstract::Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system develop...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Bui NL,Pandey V,Zhu T,Ma L,Basappa,Lobie PE

    更新日期:2018-02-28 00:00:00

  • Non-random structural chromosomal changes in ovarian cancer: i(5p) a novel recurrent abnormality.

    abstract::Ovarian cancer represents the leading cause of death among patients with gynecological cancer. The genetic changes underlying the initiation and progression of ovarian cancer have not been well defined. However, non-random structural chromosomal changes have been identified with common chromosomal breakpoints. We have...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Panani AD,Roussos C

    更新日期:2006-04-08 00:00:00

  • Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters.

    abstract::The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment of cancer. Numerous mechanisms have been recognized that cause MDR, but one of the most important mechanisms is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which the ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Fan YF,Zhang W,Zeng L,Lei ZN,Cai CY,Gupta P,Yang DH,Cui Q,Qin ZD,Chen ZS,Trombetta LD

    更新日期:2018-05-01 00:00:00

  • Hsp90 inhibition by AUY922 as an effective treatment strategy against myxoid liposarcoma.

    abstract::Liposarcoma is one of the most common soft tissue sarcomas in adults. Recognized histological subtypes include well differentiated/dedifferentiated liposarcoma (WD/DDLS), myxoid liposarcoma (MLS) and pleomorphic liposarcoma. Currently, there are no proper subtype-specific treatments due to the genetic, histological an...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Steinmann S,Gali-Muhtasib H,Huebner K,Al-Halabi R,Abou Merhi R,Aman P,Agaimy A,Haller F,Schneider-Stock R

    更新日期:2015-10-28 00:00:00

  • Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.

    abstract::Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: da Silva TC,Paula da Silva A,Akisue G,Luis Avanzo J,Kazumi Nagamine M,Fukumasu H,Matsuzaki P,César Raspantini P,Haraguchi M,Lima Górniak S,Dagli ML

    更新日期:2005-08-26 00:00:00

  • IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT-mediated induction of p21.

    abstract::Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocr...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lui AJ,Geanes ES,Ogony J,Behbod F,Marquess J,Valdez K,Jewell W,Tawfik O,Lewis-Wambi J

    更新日期:2017-07-28 00:00:00

  • Steroid receptors in human lung cancer cytosols.

    abstract::Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chaudhuri PK,Thomas PA,Walker MJ,Briele HA,Das Gupta TK,Beattie CW

    更新日期:1982-09-01 00:00:00

  • Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.

    abstract::The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlate...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Siboni G,Amit-Patito I,Weizman E,Waintraub-Porat M,Weitman H,Ehrenberg B,Malik Z

    更新日期:2003-06-30 00:00:00

  • A novel class of antitumour agents. II. In vitro testing.

    abstract::Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Emminger A,Kahmann E,Savage DS

    更新日期:1977-03-01 00:00:00

  • Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells.

    abstract::Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Mukhtar E,Adhami VM,Sechi M,Mukhtar H

    更新日期:2015-10-28 00:00:00

  • Evidence for arylamine N-acetyltransferase in the nematode Anisakis simplex.

    abstract::N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

    更新日期:1996-08-23 00:00:00

  • Immune modulation in advanced radiotherapies: Targeting out-of-field effects.

    abstract::By virtue of being a localized treatment modality, radiotherapy is unable to deliver a tumoricidal radiation dose to tissues outside of the irradiated field. Nevertheless, ionizing radiation may result in radiation damage mediated by a bystander like effect away from the irradiated field, but this response is likely t...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Hanna GG,Coyle VM,Prise KM

    更新日期:2015-11-28 00:00:00