Abstract：
:Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, we recently showed that microscopic tumors less than 1mm diameter were severely hypoxic. In this review, models and techniques for the study of hypoxia in microscopic tumors are discussed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Li XF,O'Donoghue JAdoi
10.1016/j.canlet.2008.02.037subject
Has Abstractpub_date
2008-06-18 00:00:00pages
172-80issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00134-1journal_volume
264pub_type
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