Microsomal biphenyl 2-hydroxylation in the presence of some carcinogenic alkylaryltriazenes.

abstract：:Arginine deiminase (ADI), isolated from Mycoplasma cell extracts, has been suggested to inhibit endothelial cell growth in vitro. However, anti-angiogenic activity by ADI has not yet been demonstrated. In this study, we investigated the in vitro effect of recombinant ADI (rADI) on the growth, migration, and tube forma...

journal_title：Cancer letters

authors： Beloussow K,Wang L,Wu J,Ann D,Shen WC

更新日期：2002-09-26 00:00:00

abstract：:Chemotherapeutic multidrug resistance (MDR) is a significant challenge to overcome in clinic practice. Several mechanisms contribute to MDR, one of which is the augmented drug efflux induced by the upregulation of ABCB1 in cancer cells. Regorafenib, a multikinase inhibitor targeting the RAS/RAF/MEK/ERK pathway, was ap...

journal_title：Cancer letters

authors： Wang YJ,Zhang YK,Zhang GN,Al Rihani SB,Wei MN,Gupta P,Zhang XY,Shukla S,Ambudkar SV,Kaddoumi A,Shi Z,Chen ZS

更新日期：2017-06-28 00:00:00

abstract：:In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...

journal_title：Cancer letters

authors： Ip C

更新日期：1988-04-01 00:00:00

abstract：:To investigate whether particular patterns of food consumption are related to the occurrence of breast and colon cancer, two simultaneous case-control studies of French-Canadians with 616 cases (414 breast cancer, 202 colon cancer) and 429 population-based controls were carried out. Food consumption data were obtained...

journal_title：Cancer letters

authors： Nkondjock A,Ghadirian P

更新日期：2005-06-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

journal_title：Cancer letters

authors： Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

更新日期：2015-12-01 00:00:00

abstract：:The kinase insert domain-containing receptor (KDR) is the human vascular endothelial growth factor (VEGF) receptor responsible for the mitogenic and angiogenic effects of VEGF. There is much experimental evidence to suggest that the VEGF/KDR pathway plays an important role in tumor angiogenesis, a process essential fo...

journal_title：Cancer letters

authors： Zhu Z,Lu D,Kotanides H,Santiago A,Jimenez X,Simcox T,Hicklin DJ,Bohlen P,Witte L

更新日期：1999-03-01 00:00:00

abstract：:Hepatocytes were isolated from B6C3F1 male mouse neoplastic livers (containing hepatocellular adenomas and carcinomas) or two-thirds partially hepatectomized livers and tested in primary culture for their cytotoxic response to hepatotoxins. Partially hepatectomized mouse hepatocytes were less sensitive to lindane, met...

journal_title：Cancer letters

authors： Ruch RJ,Klaunig JE,Pereira MA

更新日期：1985-04-01 00:00:00

abstract：:Human PRL-1, PRL-2, and PRL-3 tyrosine phosphatases induce the malignant transformation of epithelial cells. We tested the hypothesis that the oncogenic effects of PRL occur by increasing cellular proliferation. Cells stably transfected with PRL-1 or PRL-2 exhibited 2.7-3.3-fold increases over control cells in the rat...

journal_title：Cancer letters

authors： Werner SR,Lee PA,DeCamp MW,Crowell DN,Randall SK,Crowell PL

更新日期：2003-12-30 00:00:00

abstract：AIM:the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. METHODS:the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB...

journal_title：Cancer letters

authors： Sedlak J,Reinerova M,Hunakova L,Ausch C,Chorvath B,Rosen H,Moroz C

更新日期：1995-07-20 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) is an attractive target for cancer vaccine. However, autoimmune tolerance prevents vaccines based on HER2 protein from inducing long-lasting, highly effective anti-tumor immunity. In this study, we proved that the introduction of p-nitrophenylalanine in the universal T c...

journal_title：Cancer letters

authors： Tian H,He Y,Song X,Jiang L,Luo J,Xu Y,Zhang W,Gao X,Yao W

更新日期：2018-08-28 00:00:00

abstract：:Interferon regulatory factor (IRF1) is a potent antiviral, antitumor and immune regulatory protein. Recently, we found that activated Ras/MEK inhibits antiviral response by downregulating IRF1 expression and renders cancer cells susceptible to oncolytic viruses. In this study, we sought to determine whether IRF1 downr...

journal_title：Cancer letters

authors： AbuSara N,Razavi S,Derwish L,Komatsu Y,Licursi M,Hirasawa K

更新日期：2015-02-28 00:00:00

abstract：:Zinc finger transcription factors are DNA-binding proteins that are known to determine the identity of cells by regulating cell-specific gene expression. In addition, mutations in some members of this family have been found to be associated with several neoplasias, including Wilms' tumor and leukemias. Because the mec...

journal_title：Cancer letters

authors： Mesa K,Gebelein B,Cook T,Urrutia R

更新日期：1996-06-05 00:00:00

abstract：:Protease inhibitors have been shown to be highly effective suppressors of carcinogenesis in both in vivo and in vitro model systems. For example, the soybean derived Bowman Birk inhibitor (BBI) has been shown to inhibit colon carcinogenesis. Although the precise mechanisms by which protease inhibitors suppress carcino...

journal_title：Cancer letters

authors： Habres JM,Billings PC

更新日期：1992-04-15 00:00:00

abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...

journal_title：Cancer letters

authors： Reddi AL,Sankaranarayanan K,Arulraj HS,Devaraj N,Devaraj H

更新日期：2000-09-29 00:00:00

abstract：:Exosomes are 30-100 nm small membrane vesicles of endocytic origin that are secreted by all types of cells, and can also be found in various body fluids. Increasing evidence implicates that exosomes confer stability and can deliver their cargos such as proteins and nucleic acids to specific cell types, which subsequen...

journal_title：Cancer letters

authors： Zhou L,Lv T,Zhang Q,Zhu Q,Zhan P,Zhu S,Zhang J,Song Y

更新日期：2017-10-28 00:00:00

abstract：:The uptake of several metallophthalocyanine tetrasulfonates by cultured Chinese hamster cells was studied. Uranyl- and chloraluminium were taken up at the highest rate followed by Ni-, Zn-, Cu-, Co- and dichlorosilicon-phthalocyanine tetrasulfonate. The uptake from the growth medium containing 10% serum in which only ...

journal_title：Cancer letters

authors： Ben-Hur E,Siwecki JA,Newman HC,Crane SW,Rosenthal I

更新日期：1987-12-01 00:00:00

abstract：:We investigated the anticancer activity of erufosine in oral squamous carcinoma cell lines in terms of cell proliferation, colony formation, induction of autophagy/apoptosis, cell cycle and mTOR signaling pathway. Erufosine showed dose-dependent cytotoxicity in all cell lines, it induced autophagy as well as apoptosis...

journal_title：Cancer letters

authors： Kapoor V,Zaharieva MM,Das SN,Berger MR

更新日期：2012-06-01 00:00:00

abstract：:The tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a]anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96%...

journal_title：Cancer letters

authors： Fu PP,Von Tungeln LS,Zhan DJ,Bucci T

更新日期：1996-03-19 00:00:00

abstract：:YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found that YTHDC2 expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-dependent pathway. Knoc...

journal_title：Cancer letters

authors： Tanabe A,Tanikawa K,Tsunetomi M,Takai K,Ikeda H,Konno J,Torigoe T,Maeda H,Kutomi G,Okita K,Mori M,Sahara H

更新日期：2016-06-28 00:00:00

abstract：:We previously reported that prostaglandin E(2) contributes to colon carcinogenesis through its binding to the prostaglandin E receptor subtype EP(1) using a genetic approach in EP(1)-knockout mice and a pharmacological approach with the EP(1) selective antagonist, ONO-8711. In the present study, we examined the effect...

journal_title：Cancer letters

authors： Watanabe K,Kawamori T,Nakatsugi S,Ohta T,Ohuchida S,Yamamoto H,Maruyama T,Kondo K,Narumiya S,Sugimura T,Wakabayashi K

更新日期：2000-08-01 00:00:00

abstract：:A high-pressure liquid chromatographic (HPLC) method using a micro-particulate silica column and gradient elution was developed that separated 12-O-tetradecanoylphorbol-13-acetate (TPA) from 20-oxo-TPA; 12-O-tetradecanoylphorbol (TP); 13-O-acetylphorbol (PA), and from the diterpene alcohol, phorbol (P). A series of ot...

journal_title：Cancer letters

authors： Berry DL,Lieber MR,Fischer SM,Slaga TJ

更新日期：1977-09-01 00:00:00

abstract：:Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...

journal_title：Cancer letters

authors： Jackson KM,DeLeon M,Verret CR,Harris WB

更新日期：2002-04-25 00:00:00

abstract：:The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...

journal_title：Cancer letters

authors： Hsu B,Marin MC,McDonnell TJ

更新日期：1995-07-20 00:00:00

abstract：:Loss of FHIT expression and p53 mutations are critical events in the early stages of lung carcinogenesis. The restoration of Fhit function in FHIT-negative cancer cells has been reported to cause tumour suppression by inhibition of cell proliferation and/or activation of apoptotic pathways. However, the studies design...

journal_title：Cancer letters

authors： Cavazzoni A,Galetti M,Fumarola C,Alfieri RR,Roz L,Andriani F,Carbognani P,Rusca M,Sozzi G,Petronini PG

更新日期：2007-02-08 00:00:00

abstract：:Chronic elevated free fatty (FFA) levels are linked to metabolic disorders and tumorigenesis. However, the molecular mechanism by which FFAs induce cancer remains poorly understood. Here, we show that the tumor suppressor PTEN protein levels were decreased in high fat diet (HFD) fed mice. As palmitic acid (PA, C16:0) ...

journal_title：Cancer letters

authors： Bai D,Wu Y,Deol P,Nobumori Y,Zhou Q,Sladek FM,Liu X

更新日期：2021-01-01 00:00:00

abstract：:Human kinome/phosphatome screen identified CAMK2N1 genes suppressing the development of human hepatocellular carcinoma (HCC). CAMK2N1 downregulation was found in 47% HCCs and associated with poor prognosis. The downregulation was mainly attributed to its genome deletion (28.4%) and DNA hypermethylation of its promoter...

journal_title：Cancer letters

authors： Peng JM,Tseng RH,Shih TC,Hsieh SY

更新日期：2021-01-28 00:00:00

abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

journal_title：Cancer letters

authors： Hu G,Tu W,Yang L,Peng G,Yang L

更新日期：2020-03-31 00:00:00

abstract：:The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications...

journal_title：Cancer letters

authors： Zhang J,Shen L,Sun LQ

更新日期：2015-07-28 00:00:00

abstract：:Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...

journal_title：Cancer letters

authors： Yaacoub K,Pedeux R,Tarte K,Guillaudeux T

更新日期：2016-08-10 00:00:00

abstract：:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

journal_title：Cancer letters

authors： Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

更新日期：1978-01-01 00:00:00