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The regulation of radiosensitivity by p53 and its acetylation.

Abstract：

:The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications and is indispensable for its activation that is a reversible enzymatic process. Both acetylation and deacetylation of p53 are involved in the fine regulation of cellular responses to DNA damage and genotoxic stress, such as radiation. Targeting the acetylation of p53 may enable the modulation of radio-sensitivity of cancer cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Zhang J,Shen L,Sun LQ

doi

10.1016/j.canlet.2015.04.015

subject

Has Abstract

pub_date

2015-07-28 00:00:00

pages

108-18

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(15)00283-9

journal_volume

363

pub_type

杂志文章,评审

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