Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.

abstract：:Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

journal_title：Cancer letters

authors： Steglich A,Vehlow A,Eke I,Cordes N

更新日期：2015-02-28 00:00:00

abstract：:Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A ampli...

journal_title：Cancer letters

authors： Bodvarsdottir SK,Hilmarsdottir H,Birgisdottir V,Steinarsdottir M,Jonasson JG,Eyfjord JE

更新日期：2007-04-08 00:00:00

abstract：:gamma-Glutamyltranspeptidase (gamma-GTP) activity was found in a human pancreatic cancer cell line, HPC-Y1, cultivated in a serum-free chemically defined medium. The gamma-GTP stained in the cytoplasms as fine granules and was produced constantly in a protein-free chemically defined medium. The detergent- or protease-...

journal_title：Cancer letters

authors： Yamaguchi N,Sugimoto M,Kawai K

更新日期：1984-12-01 00:00:00

abstract：:Inhibition of 5-Lox induces apoptosis in prostate cancer cells by inactivating PKCε which is prevented by 5-oxoETE, and activators of PKCε prevent 5-Lox inhibition-induced apoptosis, suggesting that 5-Lox metabolites exert survival signaling via PKCε. However, mechanisms by which 5-Lox metabolites activate PKCε are no...

journal_title：Cancer letters

authors： Sarveswaran S,Ghosh J

更新日期：2013-08-09 00:00:00

abstract：:Peroxiredoxin 2 (Prdx2) has been shown to act as an antioxidant whose main function is to reduce hydrogen peroxide (H2O2) in cells, and Prdx2 is abnormally elevated in colorectal cancer (CRC). However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect o...

journal_title：Cancer letters

authors： Lu W,Fu Z,Wang H,Feng J,Wei J,Guo J

更新日期：2014-02-28 00:00:00

abstract：:Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction...

journal_title：Cancer letters

authors： Nicklin SA,Dishart KL,Buening H,Reynolds PN,Hallek M,Nemerow GR,Von Seggern DJ,Baker AH

更新日期：2003-11-25 00:00:00

abstract：:Since CP always exists in aqueous solution as a mixture of native drug and various aqua and hydroxo species, it is conceivable that one or more of these aquated species is the main form of the drug that enters the cell. To test this hypothesis, we examined the accumulation by 2008 human ovarian carcinoma cells of CP a...

journal_title：Cancer letters

authors： Jennerwein M,Andrews PA

更新日期：1994-06-30 00:00:00

abstract：:The in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbena[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-...

journal_title：Cancer letters

authors： Pal K,Grover PL,Sims P

更新日期：1979-06-01 00:00:00

abstract：:The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...

journal_title：Cancer letters

authors： Nesnow S,Triplett LL,Slaga TJ

更新日期：1984-05-01 00:00:00

abstract：:Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

journal_title：Cancer letters

authors： Zheng Y,Wang Z,Wei S,Liu Z,Chen G

更新日期：2021-02-28 00:00:00

abstract：:Recent work has demonstrated that oncogenes and tumor suppressor proteins regulate apoptotic cell death. Current efforts are therefore directed at determining how they exert their effects. It appears that oncogenes can control activation of the apoptosis endonuclease(s) either by regulating the signal(s) that trigger ...

journal_title：Cancer letters

authors： McConkey DJ,Fernandez A,Trent J 2nd,Ananthaswamy HN

更新日期：1995-07-20 00:00:00

abstract：:Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-beta-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-beta-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-beta-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-alpha-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoy...

journal_title：Cancer letters

authors： Colombo D,Compostella F,Ronchetti F,Scala A,Toma L,Kuchide M,Tokuda H,Nishino H

更新日期：2000-12-20 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...

journal_title：Cancer letters

authors： Lv W,Chen N,Lin Y,Ma H,Ruan Y,Li Z,Li X,Pan X,Tian X

更新日期：2016-06-01 00:00:00

abstract：:The anti-carcinogenic activity of dietary fruit and vegetables observed in several epidemiological and experimental animal studies is likely to be an effect of the combined exposure to a large number of substances acting together. This is plausible, as these compounds are present simultaneously in a diet containing ve...

journal_title：Cancer letters

authors： Vang O,Rasmussen BF,Andersen O

更新日期：1997-03-19 00:00:00

abstract：:Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and Citrus hystrix (Rutaceae) are edible plants that are commonly used as flavors or condiments in various Thai food dishes. They are known to exert strong anti-promoting activity in a test of tumor promoter-induced Epstein-Barr virus (EBV) activa...

journal_title：Cancer letters

authors： Tiwawech D,Hirose M,Futakuchi M,Lin C,Thamavit W,Ito N,Shirai T

更新日期：2000-10-01 00:00:00

abstract：:The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...

journal_title：Cancer letters

authors： Baxter CS,Lawrence AT

更新日期：1987-11-01 00:00:00

abstract：:Many of the polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene (B[a]P), benzanthracene (BA), 3-methylcholanthrene (3-MC)) are not only carcinogenic, but also induce AHH in human tissues. Recently, chrysene has been implicated as an etiologic determinant of chemical carcinogenesis. Here we describe the ability of c...

journal_title：Cancer letters

authors： Snodgrass DR,McLemore TL,Marshall MV,Wray NP,Cantrell ET,Busbee DL,Arnott MA

更新日期：1979-10-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...

journal_title：Cancer letters

authors： Cheng Z,Lei Z,Shen F

更新日期：2019-09-28 00:00:00

abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...

journal_title：Cancer letters

authors： Huan-huan C,Li-Li Y,Shang-Bin L

更新日期：2004-08-10 00:00:00

abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

journal_title：Cancer letters

authors： Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

更新日期：1998-06-05 00:00:00

abstract：:While the vast majority of cancers are believed to occur sporadically, most forms of cancer, both adult and paediatric, have a hereditary equivalent. In the case of adult malignancies, these include hereditary breast and ovarian cancer and syndromes such as the multiple endocrine neoplasias types 1 and 2 characterised...

journal_title：Cancer letters

authors： Marsh D,Zori R

更新日期：2002-07-26 00:00:00

abstract：:Parthanatos is a new form of programmed cell death that is regulated by hyper-activated PARP-1, and is emerging as a new strategy to kill cancer cells. Deoxypodophyllotoxin (DPT) is a natural chemical that is found to induce cancer cell death, in which the role of parthanatos is unknown. Thus, we investigated this iss...

journal_title：Cancer letters

authors： Ma D,Lu B,Feng C,Wang C,Wang Y,Luo T,Feng J,Jia H,Chi G,Luo Y,Ge P

更新日期：2016-02-28 00:00:00

abstract：:Mammaglobin B is a recently-isolated gene speculated to belong to the uteroglobin gene family and is overexpressed in primary breast cancers. We investigated mammaglobin B mRNA expression in various cancers of the digestive system. Given the absence of mammaglobin B expression in normal lymph nodes, we also assessed t...

journal_title：Cancer letters

authors： Aihara T,Fujiwara Y,Miyake Y,Okami J,Okada Y,Iwao K,Sugita Y,Tomita N,Sakon M,Shiozaki H,Monden M

更新日期：2000-03-13 00:00:00

abstract：:Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. Over a decade ago, this phytochemical was identified as a likely chemopreventive agent based on its ability to induce Phase 2 detoxification enzymes, as well as to inhibit P...

journal_title：Cancer letters

authors： Myzak MC,Dashwood RH

更新日期：2006-02-28 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...

journal_title：Cancer letters

authors： Zhong H,Mabjeesh N,Willard M,Simons J

更新日期：2002-07-26 00:00:00

abstract：:Oxidative stress is implicated in the etiology of cancer, hence compounds that alleviate oxidative stress by inducing enzymes that defend against free radical damage might be useful as cancer chemopreventives. Glutathione S-transferase (GST) has been suggested to be a candidate for a critical enzyme in protecting cell...

journal_title：Cancer letters

authors： Fiander H,Schneider H

更新日期：2000-08-11 00:00:00

abstract：:Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant found in plants, such as grapes, that studies suggest has cancer chemopreventive activity. We investigated the effects of resveratrol on DNA binding via esterification reactions with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP...

journal_title：Cancer letters

authors： Dubuisson JG,Dyess DL,Gaubatz JW

更新日期：2002-08-08 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

journal_title：Cancer letters

authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

更新日期：2019-08-28 00:00:00

abstract：:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these muta...

journal_title：Cancer letters

authors： Thieu K,Ruiz ME,Owens DM

更新日期：2013-09-10 00:00:00

abstract：:We examined the simultaneous uptake of porphyrin and (LDL) by four established cell lines of glioma and normal fibroblasts using flow cytometry (FCM). The results indicated porphyrin and LDL showed competitive conjugation with the LDL receptor. These results support the theory of the porphyrin uptake via the LDL recep...

journal_title：Cancer letters

authors： Shibata Y,Matsumura A,Yoshida F,Yamamoto T,Nakai K,Nose T,Sakata I,Nakajima S

更新日期：2001-05-10 00:00:00