Postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract in the detoxication pathway of suckling neonates and lactating mice.

Abstract:

:The present study evaluates the postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract via assessing the modulation in the biotransformation system enzymes of suckling neonates and lactating mice. The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induced a significant increase in the hepatic levels of glutathione S-transferase (GST) and acid soluble sulfhydryl (-SH) after 14 or 21 days treatment in lactating dams (P < 0.01) and translactationally exposed neonates (P < 0.05). However, the elevation (P < 0.05) in hepatic cytochrome b5 (Cyt. b5) and cytochrome P-450 (Cyt. P-450) levels was observed only in the lactating dams treated with the respective extracts of peel, seed or whole fruit of Momordica. In lactating dams and suckling neonates the modulated levels of biotransformation system enzymes suggest the potential for the translactational passage of active principle(s) and/or metabolites of Momordica.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Singh A,Singh SP,Bamezai R

doi

10.1016/s0304-3835(97)00381-9

subject

Has Abstract

pub_date

1998-01-09 00:00:00

pages

121-6

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(97)00381-9

journal_volume

122

pub_type

杂志文章
  • Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.

    abstract::The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00230-4

    authors: Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

    更新日期:1998-11-27 00:00:00

  • Application of CRISPR-mediated genome engineering in cancer research.

    abstract::Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research communi...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2016.03.029

    authors: Sayin VI,Papagiannakopoulos T

    更新日期:2017-02-28 00:00:00

  • N-Myc down-regulated gene 1 mediates proliferation, invasion, and apoptosis of hepatocellular carcinoma cells.

    abstract::The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2007.12.010

    authors: Yan X,Chua MS,Sun H,So S

    更新日期:2008-04-08 00:00:00

  • The enigmatic effects of caffeine in cell cycle and cancer.

    abstract::Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle function, induce programmed cell death or apoptosis and perturb key cell cycle regulatory proteins. Although the effects of caffeine have been heavily investigated, muc...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2006.03.032

    authors: Bode AM,Dong Z

    更新日期:2007-03-08 00:00:00

  • Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis.

    abstract::Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(86)90098-4

    authors: Walaszek Z,Hanausek-Walaszek M,Webb TE

    更新日期:1986-10-01 00:00:00

  • Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine.

    abstract::Expression of cyclooxygenase (COX)-2 protein in preneoplastic and neoplastic lung lesions induced by the administration of 2000 ppm of N-nitrosobis(2-hydroxypropyl)amine (BHP) in the drinking water to Wistar male rats, was examined immunohistochemically. The majority of alveolar/bronchiolar adenomas (ADs) and all aden...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00325-0

    authors: Kitayama W,Denda A,Yoshida J,Sasaki Y,Takahama M,Murakawa K,Tsujiuchi T,Tsutsumi M,Konishi Y

    更新日期:2000-02-01 00:00:00

  • Oxidative DNA base damage in cancerous tissues of patients undergoing brachytherapy.

    abstract::This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00170-0

    authors: Foksinski M,Jaruga P,Makarewicz R,Olinski R

    更新日期:1998-10-23 00:00:00

  • p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations.

    abstract::Alteration of the p16 tumor suppressor gene has been implicated as a critical lesion in the molecular pathogenesis of esophageal adenocarcinoma. The aim of this study was to characterize the spectrum of p16 alterations in surgically resected esophageal tissues, comprising histologically normal esophageal squamous and ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.06.025

    authors: Hardie LJ,Darnton SJ,Wallis YL,Chauhan A,Hainaut P,Wild CP,Casson AG

    更新日期:2005-01-20 00:00:00

  • IL-6 induced M1 type macrophage polarization increases radiosensitivity in HPV positive head and neck cancer.

    abstract::Radiation is a crucial component of head and neck squamous cell carcinoma (HNSC) treatment. Human papillomavirus-positive (HPV+) HNSC is significantly more radiosensitive than HPV- HNSC, but the mechanism underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophage subpopula...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2019.04.032

    authors: Chen X,Fu E,Lou H,Mao X,Yan B,Tong F,Sun J,Wei L

    更新日期:2019-08-01 00:00:00

  • Gadolinium neutron-capture therapy using novel gadopentetic acid-chitosan complex nanoparticles: in vivo growth suppression of experimental melanoma solid tumor.

    abstract::The potential of gadolinium neutron-capture therapy (Gd-NCT) for cancer was evaluated using chitosan nanoparticles as a novel gadolinium device. The nanoparticles, incorporating 1200 microg of natural gadolinium, were administered intratumorally twice in mice bearing subcutaneous B16F10 melanoma. The thermal neutron i...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00388-2

    authors: Tokumitsu H,Hiratsuka J,Sakurai Y,Kobayashi T,Ichikawa H,Fukumori Y

    更新日期:2000-03-31 00:00:00

  • Dose-response study of MeIQx carcinogenicity in F344 male rats.

    abstract::The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimen...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(94)90295-x

    authors: Kushida H,Wakabayashi K,Sato H,Katami M,Kurosaka R,Nagao M

    更新日期:1994-08-15 00:00:00

  • Volatile N-nitrosamines in gastric juice of patients with various conditions of the gastrointestinal tract determined by gas chromatography-mass spectrometry and related to intragastric pH and nitrate and nitrite levels.

    abstract::Gastric juice samples of 71 patients undergoing upper gastrointestinal endoscopy were collected as well as saliva samples from 40 of these patients. Age, sex, endoscopic diagnosis and medication were recorded. The gastric juice samples were analyzed for the presence and quantity of individual volatile N-nitrosamines, ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(97)00467-9

    authors: Dallinga JW,Pachen DM,Lousberg AH,van Geel JA,Houben GM,Stockbrügger RW,van Maanen JM,Kleinjans JC

    更新日期:1998-02-27 00:00:00

  • Long non-coding RNAs: Emerging regulators for chemo/immunotherapy resistance in cancer stem cells.

    abstract::Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.11.010

    authors: Shen C,Yang C,Xia B,You M

    更新日期:2021-03-01 00:00:00

  • Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.

    abstract::Myeloid lineage immune cells, such as macrophages and dendritic cells, play important roles in the induction of antitumor immunity during the initial stage of the cancer-immunity cycle, eliciting antitumor adaptive immunity by phagocytosing cancer cells and processing cancer-specific antigens, and then presenting thes...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2019.03.018

    authors: Park SY,Kim IS

    更新日期:2019-06-28 00:00:00

  • Nitrosation products from the plant Ephedra altissima and their potential endogenous formation.

    abstract::The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(87)90045-0

    authors: Tricker AR,Wacker CD,Preussmann R

    更新日期:1987-05-01 00:00:00

  • Inhibitory effect of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid, on azoxymethane-induced intestinal carcinogenesis in rats.

    abstract::Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(92)90220-p

    authors: Mori H,Yoshimi N,Sugie S,Tanaka T,Morishita Y,Jinlong G,Tamai Y,Torihara M,Yamahara J

    更新日期:1992-09-30 00:00:00

  • Identification and characterization of zinc finger encoding genes from the tumoral exocrine pancreatic cell line AR42J.

    abstract::Zinc finger transcription factors are DNA-binding proteins that are known to determine the identity of cells by regulating cell-specific gene expression. In addition, mutations in some members of this family have been found to be associated with several neoplasias, including Wilms' tumor and leukemias. Because the mec...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(96)04204-8

    authors: Mesa K,Gebelein B,Cook T,Urrutia R

    更新日期:1996-06-05 00:00:00

  • Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer.

    abstract::Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2014.12.027

    authors: Awasthi N,Hinz S,Brekken RA,Schwarz MA,Schwarz RE

    更新日期:2015-03-01 00:00:00

  • In vitro toxicity evaluation in the development of new anticancer drugs-genistein glycosides.

    abstract::In vitro cytotoxicity tests currently in use applied in the developmental stages of anticancer drug discovery are able to select the most potent compounds, but are not predictive of their potential toxicity. In this study, we have demonstrated the applicability of neutral red uptake assay using mouse fibroblasts Balb/...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2005.01.014

    authors: Popiołkiewicz J,Polkowski K,Skierski JS,Mazurek AP

    更新日期:2005-11-08 00:00:00

  • 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.

    abstract::14-3-3 sigma is a negative regulator of the cell cycle and contributes to G2 arrest. Thus far, the lack of its expression due to hypermethylation of the CpG islands has been reported in some carcinomas. In this study, we investigated the expression of 14-3-3 sigma in thyroid neoplasms by means of immunohistochemistry ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(03)00282-9

    authors: Ito Y,Miyoshi E,Uda E,Yoshida H,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Matsuura N,Kakudo K,Kuma K,Miyauchi A

    更新日期:2003-10-28 00:00:00

  • All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells.

    abstract::All-trans retinoic acid (ATRA) inhibits proliferation of cancer. However, the effects of ATRA on scattering and invasion of pancreatic cancer cells remain unknown. Also, the effects of ATRA on c-Met expression in pancreatic cancer have never been addressed so far. The effects of ATRA on a pancreatic cancer cell line, ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.10.016

    authors: Leelawat K,Ohuchida K,Mizumoto K,Mahidol C,Tanaka M

    更新日期:2005-06-28 00:00:00

  • Differential responsiveness to agents which stimulate cAMP production in normal versus neoplastic mouse lung epithelial cells.

    abstract::We examined the responsiveness of normal and neoplastic lung cells to agents which stimulate cAMP production. While their basal cAMP levels were similar, spontaneous in vitro transformant E9 cells and tumor-derived PCC4 cells produced much less cAMP in response to 1 microM isoproterenol compared to non-tumorigenic C10...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(92)90137-k

    authors: Lange-Carter CA,Droms KA,Vuillequez JJ,Malkinson AM

    更新日期:1992-12-24 00:00:00

  • Cytotoxic effects of 125I-labeled PBZr ligand PK 11195 in prostatic tumor cells: therapeutic implications.

    abstract::The effect of [125I]PK 11195 was examined in human prostatic tumor cells (DU 145) in culture and compared with Na[125I] and non-radioactive PK 11195. [125I]PK 11195 was clearly cytocidal. The data for dose-related cell survival with [125I]PK 11195 showed a linear relationship. Na[125I] or non-labeled PK 11195 at simil...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00258-4

    authors: Alenfall J,Kant R,Batra S

    更新日期:1998-12-25 00:00:00

  • Epigenetic silencing of chemokine CCL2 represses macrophage infiltration to potentiate tumor development in small cell lung cancer.

    abstract::Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.11.034

    authors: Zheng Y,Wang Z,Wei S,Liu Z,Chen G

    更新日期:2021-02-28 00:00:00

  • BARD1 splice variants display mislocalization in breast cancer cells and can alter the apoptotic response to cisplatin.

    abstract::We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi, ΔRIN, epsilon) for subcellular localization and apoptotic efficacy. ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2016.07.034

    authors: Marzec KA,Martino-Echarri E,Irminger-Finger I,Henderson BR

    更新日期:2016-10-10 00:00:00

  • Suppression of Ehrlich ascites tumor growth in mice by starvation and streptozotocin-induced diabetes.

    abstract::Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(85)90035-7

    authors: Fung KP,Chan TW,Choy YM

    更新日期:1985-09-30 00:00:00

  • Sox17 regulates proliferation and cell cycle during gastric cancer progression.

    abstract::Sox17, a transcription factor, was considered as an antagonist to inhibit canonical Wnt/β-catenin signaling in several malignant tumors. Extremely little is known about Sox17 in gastric cancer. Therefore, the aim of this study was to elucidate the vital role of Sox17 in the tumorigenesis and progression of gastric can...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2011.03.024

    authors: Ye YW,Wu JH,Wang CM,Zhou Y,Du CY,Zheng BQ,Cao X,Zhou XY,Sun MH,Shi YQ

    更新日期:2011-08-28 00:00:00

  • Omics-based nanomedicine: the future of personalized oncology.

    abstract::The traditional "one treatment fits all" paradigm disregards the heterogeneity between cancer patients, and within a particular tumor, thus limit the success of common treatments. Moreover, current treatment lacks specificity and therefore most of the anticancer drugs induce severe adverse effects. Personalized medici...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2013.07.029

    authors: Rosenblum D,Peer D

    更新日期:2014-09-28 00:00:00

  • The field bean protease inhibitor has the potential to suppress B16F10 melanoma cell lung metastasis in mice.

    abstract::Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00090-1

    authors: Banerji A,Fernandes A,Bane S,Ahire S

    更新日期:1998-07-03 00:00:00

  • NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy.

    abstract::Nuclear factor-kappaB (NF-kappaB) has been shown to play an important role in the development and progression of cancer. In this study, we systematically examined NF-kappaBp65 signaling pathway in both human hepatocellular carcinoma (HCC) tissue and HCC cell lines. NF-kappaBp65 signaling pathway is aberrantly expresse...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2008.12.031

    authors: Wu JM,Sheng H,Saxena R,Skill NJ,Bhat-Nakshatri P,Yu M,Nakshatri H,Maluccio MA

    更新日期:2009-06-18 00:00:00