Abstract:
:The present study evaluates the postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract via assessing the modulation in the biotransformation system enzymes of suckling neonates and lactating mice. The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induced a significant increase in the hepatic levels of glutathione S-transferase (GST) and acid soluble sulfhydryl (-SH) after 14 or 21 days treatment in lactating dams (P < 0.01) and translactationally exposed neonates (P < 0.05). However, the elevation (P < 0.05) in hepatic cytochrome b5 (Cyt. b5) and cytochrome P-450 (Cyt. P-450) levels was observed only in the lactating dams treated with the respective extracts of peel, seed or whole fruit of Momordica. In lactating dams and suckling neonates the modulated levels of biotransformation system enzymes suggest the potential for the translactational passage of active principle(s) and/or metabolites of Momordica.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Singh A,Singh SP,Bamezai Rdoi
10.1016/s0304-3835(97)00381-9subject
Has Abstractpub_date
1998-01-09 00:00:00pages
121-6issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(97)00381-9journal_volume
122pub_type
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