Gut microbiota: A new piece in understanding hepatocarcinogenesis.

abstract：:MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...

journal_title：Cancer letters

authors： Tricarico R,Bet P,Ciambotti B,Di Gregorio C,Gatteschi B,Gismondi V,Toschi B,Tonelli F,Varesco L,Genuardi M

更新日期：2009-02-18 00:00:00

abstract：:A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor c...

journal_title：Cancer letters

authors： Walaszek Z,Hanausek-Walaszek M,Schumm DE,Webb TE

更新日期：1983-10-01 00:00:00

abstract：:Glucocorticoids (GCs) are pro-apoptotic as a co-medication to treat leukemia and lymphoma. However, the effects in breast cancer (BC) are diverse with mechanisms less understood. In this study using BC model cell MCF7, we found that dexamethasone (Dex) promotes cell proliferation. Gene expression analysis identified t...

journal_title：Cancer letters

authors： Khan S,Lopez-Dee Z,Kumar R,Ling J

更新日期：2013-08-28 00:00:00

abstract：:We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-alpha and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was d...

journal_title：Cancer letters

authors： Zhang ZJ,Wang JL,Muhr C,Smits A

更新日期：1996-02-27 00:00:00

abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

journal_title：Cancer letters

authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

更新日期：1982-05-01 00:00:00

abstract：:Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as...

journal_title：Cancer letters

authors： Serra M,Scotlandi K

更新日期：2009-11-01 00:00:00

abstract：:Chemically-induced mutagenesis and carcinogenesis is modulated by various plant products, some of which are present in the human diet. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent carcinogen in tobacco and tobacco smoke, is activated by microsomal enzymes. In this study, we investigated the effects o...

journal_title：Cancer letters

authors： Miller CH,Zhang Z,Hamilton SM,Teel RW

更新日期：1993-11-30 00:00:00

abstract：:Breast carcinomas are frequently characterized by hyperactivated c-erbB receptor tyrosine kinase signaling. Combination of anti-proliferative retinoids with growth-inhibitory c-erbB-specific agents might induce therapeutic benefit. We demonstrate close interactions between the c-erbB and the retinoic acid receptor sys...

journal_title：Cancer letters

authors： Flicker SH,Schneider SM,Offterdinger M,Dittrich E,Fazeny B,Valenta R,Huber H,Dittrich C,Grunt TW

更新日期：1997-05-01 00:00:00

abstract：:Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...

journal_title：Cancer letters

authors： Richter-Reichhelm HB,Emura M,Schneider P,Mohr U

更新日期：1979-11-01 00:00:00

abstract：:Relative frequencies of diethylnitrosamine (DEN)-initiated foci of altered hepatocytes appearing in response to promotion by either dietary phenobarbital or a topically applied coal-derived organic mixture (CDM) were investigated in male and female rats. The focus population was examined for two histochemical markers,...

journal_title：Cancer letters

authors： Peraino C,Haugen DA,Carnes BA,Reilly CA Jr,Springer DL,Mahlum DD

更新日期：1987-10-30 00:00:00

abstract：:Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...

journal_title：Cancer letters

authors： Zhang L,Sun ZJ,Bian Y,Kulkarni AB

更新日期：2013-05-01 00:00:00

abstract：:Ring1 and YY1 binding protein (RYBP) is a member of the Polycomb group (PcG) proteins and regulates cell growth through both PcG-dependent and -independent mechanisms. Our initial study indicated that RYBP is down-regulated in human non-small cell lung cancer (NSCLC) tissues. The present study determined the molecular...

journal_title：Cancer letters

authors： Voruganti S,Xu F,Qin JJ,Guo Y,Sarkar S,Gao M,Zheng Z,Wang MH,Zhou J,Qian B,Zhang R,Wang W

更新日期：2015-12-28 00:00:00

abstract：:In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response di...

journal_title：Cancer letters

authors： Teplitzky SR,Kiefer TL,Cheng Q,Dwivedi PD,Moroz K,Myers L,Anderson MB,Collins A,Dai J,Yuan L,Spriggs LL,Blask DE,Hill SM

更新日期：2001-07-26 00:00:00

abstract：:In order to determine the effects of intermittent hormonal manipulation on the promotion stage of rat prostate carcinogenesis, testosterone and/or estrogen were administered to F344 rats for 40 weeks after 20-weeks treatment with the prostate carcinogen, 3,2'-dimethyl-4-aminobiphenyl. For this purpose testosterone pro...

journal_title：Cancer letters

authors： Cui L,Mori T,Takahashi S,Imaida K,Akagi K,Yada H,Yaono M,Shirai T

更新日期：1998-01-09 00:00:00

abstract：:In our previous rat study, an established intracranial C6 glioma was successfully treated using intratumoral injection of mesenchymal stem cells transduced with the herpes simplex virus-thymidine kinase gene (MSCtk) and systemic administration of ganciclovir (GCV). In the present study, effect of the "bystander effect...

journal_title：Cancer letters

authors： Amano S,Gu C,Koizumi S,Tokuyama T,Namba H

更新日期：2011-07-01 00:00:00

abstract：:Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system develop...

journal_title：Cancer letters

authors： Bui NL,Pandey V,Zhu T,Ma L,Basappa,Lobie PE

更新日期：2018-02-28 00:00:00

abstract：:This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 ...

journal_title：Cancer letters

authors： Ishida H,Miwa H,Tatsuta M,Masutani S,Imamura H,Shimizu J,Ezumi K,Kato H,Kawasaki T,Furukawa H,Kawakami H

更新日期：2004-04-15 00:00:00

abstract：:We present the data of 105 serum samples from 20 patients suffering from cervical cancer. Mean serum levels of basic fibroblast growth factor (bFGF) in patients with or without tumor present were 31.3 +/- 32.1 (minimum 0, maximum 156.7) pg/ml and 4.8 +/- 6.8 (minimum 0, maximum 29.6) pg/ml, respectively (P = 0.0001). ...

journal_title：Cancer letters

authors： Sliutz G,Tempfer C,Obermair A,Reinthaller A,Gitsch G,Kainz C

更新日期：1995-08-01 00:00:00

abstract：:It is known that hepatocyte growth factor binding to its receptor regulates gastric cancer progression and metastasis. HGF was found to up-regulate the expression of cyclooxygenase-2 gene and increases prostaglandin (PG) synthesis in gastric mucosa cells. Overexpression of COX-2 and increased PG secretion have also be...

journal_title：Cancer letters

authors： Chen JH,Wu CW,Kao HL,Chang HM,Li AF,Liu TY,Chi CW

更新日期：2006-08-08 00:00:00

abstract：:Eight chlorinated ethanes and 3 chlorinated ethylenes were tested in the BALB/c-3T3 cell transformation assay. Under the conditions of the assay, vinyl chloride and 1,1,1-trichloroethane induced a clear positive transformation response while 1,1,2-trichloroethane and trichloroethylene were weakly positive. Chloroethan...

journal_title：Cancer letters

authors： Tu AS,Murray TA,Hatch KM,Sivak A,Milman HA

更新日期：1985-08-01 00:00:00

abstract：:The role of the gastrointestinal microflora in the nitrate-dependent formation of nitrosoproline was assessed in control and antibiotic-treated rats. Urinary nitrosoproline excretion as an index of in vivo nitrosamine formation was shown to be unaffected by bacterial decontamination of the alimentary tract, and procee...

journal_title：Cancer letters

authors： Mallett AK,Rowland IR,Cottrell RC,Gangolli SD

更新日期：1984-12-01 00:00:00

abstract：:MICAL2 is a tumor-promoting factor involved in cell migration, invasion, deformation, and proliferation not yet fully explored in lung adenocarcinoma (LUAD). This study demonstrated that MICAL2 was overexpressed and cytoplasm-enriched in LUAD tissues. Moreover, high cytoplasmic MICAL2 and/or total MICAL2 expression le...

journal_title：Cancer letters

authors： Zhou W,Liu Y,Gao Y,Cheng Y,Chang R,Li X,Zhou Y,Wang S,Liang L,Duan C,Zhang C

更新日期：2020-07-28 00:00:00

abstract：:Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis, which is elevated in inflammation, we examined whether the anti-inflammatory mechanism ...

journal_title：Cancer letters

authors： Kuo CL,Chi CW,Liu TY

更新日期：2004-01-20 00:00:00

abstract：:Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commo...

journal_title：Cancer letters

authors： Ivey JW,Bonakdar M,Kanitkar A,Davalos RV,Verbridge SS

更新日期：2016-09-28 00:00:00

abstract：:d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, wh...

journal_title：Cancer letters

authors： Torelli S,Masoudi F,Prasad KN

更新日期：1988-03-01 00:00:00

abstract：:5-FU is commonly used for treatment of various solid tumors including colon carcinoma. We have previously demonstrated that Egr-1 induced by 5-FU enhanced TSP-1 expression in human colon cancer KM12C cells. In this study, a Genechip analysis of KM12C cells treated with 5-FU revealed down-regulation of 924 genes and up...

journal_title：Cancer letters

authors： Zhao HY,Ooyama A,Yamamoto M,Ikeda R,Haraguchi M,Tabata S,Furukawa T,Che XF,Iwashita K,Oka T,Fukushima M,Nakagawa M,Ono M,Kuwano M,Akiyama S

更新日期：2008-10-18 00:00:00

abstract：:Circulating free DNA (CFDNA) has been shown to be a good source of liver tissue-derived DNA in African and Asian patients with chronic liver disease or HCC. In Egypt, HCC is a frequent carcinoma and mostly occur in the context of chronic infection by HCV, a widespread infection in the Egyptian population. Here we have...

journal_title：Cancer letters

authors： Hosny G,Farahat N,Tayel H,Hainaut P

更新日期：2008-06-18 00:00:00

abstract：:Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...

journal_title：Cancer letters

authors： Lawson TA

更新日期：1990-08-01 00:00:00

abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...

journal_title：Cancer letters

authors： Li HW,Zhao W,Sarkar NH

更新日期：1994-05-16 00:00:00

abstract：:Precision medicine promises to better classify patients by individual clinical and biological biomarkers, which may provide an accurate assessment of disease risk, diagnosis, prognosis and treatment response. Cancer frequently displays substantial inter-tumor and intra-tumor heterogeneity and hence oncology is well su...

journal_title：Cancer letters

authors： Wu M,Zhang X,Han X,Pandey V,Lobie PE,Zhu T

更新日期：2021-03-31 00:00:00