Abstract:
:Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone substrates that are involved in signal transduction or cellular transport processes. One important non-histone substrate is tubulin. The isotypes responsible for tubulin deacetylation are HDAC6 and the NAD(+)-dependent histone deacetylase (sirtuin) Sirt2. Here we review the action of those enzymes on tubulin and present an overview over existing inhibitors with a focus on their structural interaction with the targets.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Schemies J,Sippl W,Jung Mdoi
10.1016/j.canlet.2009.01.040subject
Has Abstractpub_date
2009-08-08 00:00:00pages
222-32issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00069-Xjournal_volume
280pub_type
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