Abstract:
:Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Cheng J,Deng H,Xiao B,Zhou H,Zhou F,Shen Z,Guo Jdoi
10.1016/j.canlet.2011.10.004subject
Has Abstractpub_date
2012-02-01 00:00:00pages
12-7issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00617-3journal_volume
315pub_type
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