piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells.

Abstract:

:Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Cheng J,Deng H,Xiao B,Zhou H,Zhou F,Shen Z,Guo J

doi

10.1016/j.canlet.2011.10.004

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

12-7

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(11)00617-3

journal_volume

315

pub_type

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