Abstract:
:A plethora of tumours have characteristic oncogenic mutations which are the main causes of malignant transformation, exerting their effects through multiple signalling pathways. Downstream of such pathways, microRNAs are small non-coding RNAs that negatively regulate gene expression, assisting or antagonizing oncogenic signalling. The differential expression of microRNAs in cancer is well-documented and is considered a fundamental aspect of tumourigenesis. While data mapping the interaction between oncogenic lesions and microRNAs are accruing, we provide particular cases of such interaction. Except for notable, well-studied examples of microRNAs regulated by oncogenes, we examine the effect of this relationship in regard to tumour initiation, progression, metastasis and ultimately, its implications for the development of new therapeutics.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Paliouras AR,Monteverde T,Garofalo Mdoi
10.1016/j.canlet.2018.02.029subject
Has Abstractpub_date
2018-05-01 00:00:00pages
152-160eissn
0304-3835issn
1872-7980pii
S0304-3835(18)30162-9journal_volume
421pub_type
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