Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.

abstract：:Standard chemotherapeutic protocols, based on maximum tolerated doses, do not prevent nor overcome chemoresistance caused by the efflux transporter P-glycoprotein (Pgp). We compared the effects of two consecutive low doses versus a single high dose of doxorubicin in drug-sensitive Pgp-negative and drug-resistant Pgp-p...

journal_title：Cancer letters

authors： Riganti C,Gazzano E,Gulino GR,Volante M,Ghigo D,Kopecka J

更新日期：2015-05-01 00:00:00

abstract：:Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...

journal_title：Cancer letters

authors： Brézillon S,Radwanska A,Zeltz C,Malkowski A,Ploton D,Bobichon H,Perreau C,Malicka-Blaszkiewicz M,Maquart FX,Wegrowski Y

更新日期：2009-09-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Many kinases have been found to be intimately involved in oncogenesis and the deregulation of kinase function has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and surviv...

journal_title：Cancer letters

authors： Xia H,Kong SN,Chen J,Shi M,Sekar K,Seshachalam VP,Rajasekaran M,Goh BKP,Ooi LL,Hui KM

更新日期：2016-12-01 00:00:00

abstract：:Heparanase (HPA) is an endoglucuronidase that can promote the shedding of associated cytokines in several types of tumors. However, little is known about what controls the expression of HPA or its role in gastric cancer. In this study, we report for the first time that HGF regulates HPA expression to promote gastric c...

journal_title：Cancer letters

authors： Hao NB,Tang B,Wang GZ,Xie R,Hu CJ,Wang SM,Wu YY,Liu E,Xie X,Yang SM

更新日期：2015-05-28 00:00:00

abstract：:Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and ...

journal_title：Cancer letters

authors： Bouzyk E,Rosiek O

更新日期：1988-02-01 00:00:00

abstract：:It is now well established that increased programmed death-1-ligand 1 (PD-L1) surface expression in cancer cells and the resultant T cell suppression contribute to cancer cell immune evasion. Blockade of PD-L1 function has been shown to stimulate anti-cancer immunity. Therefore, compounds that can down-regulate PD-L1 ...

journal_title：Cancer letters

authors： Liang M,Yang H,Fu J

更新日期：2009-04-08 00:00:00

abstract：:This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...

journal_title：Cancer letters

authors： Onizawa K,Saginoya H,Furuya Y,Yoshida H

更新日期：1996-11-12 00:00:00

abstract：:Sonodynamic therapy (SDT) is a form of ultrasound therapy that has been shown to preferentially damage malignant cells based on the relatively enlarged size and altered cytology of neoplastic cells in comparison to normal cells. This study sought to determine whether cytoskeletal-directed agents that either disrupt (c...

journal_title：Cancer letters

authors： Trendowski M,Wong V,Zoino JN,Christen TD,Gadeberg L,Sansky M,Fondy TP

更新日期：2015-05-01 00:00:00

abstract：:A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, rel...

journal_title：Cancer letters

authors： Egan KM,Thompson PA,Titus-Ernstoff L,Moore JH,Ambrosone CB

更新日期：2003-09-10 00:00:00

abstract：:Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocr...

journal_title：Cancer letters

authors： Lui AJ,Geanes ES,Ogony J,Behbod F,Marquess J,Valdez K,Jewell W,Tawfik O,Lewis-Wambi J

更新日期：2017-07-28 00:00:00

abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

journal_title：Cancer letters

authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

更新日期：1996-08-23 00:00:00

abstract：:Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas ...

journal_title：Cancer letters

authors： Roomi MW,Vincent SH,Farber E,Muller-Eberhard U

更新日期：1988-12-01 00:00:00

abstract：:The etiology of prostatic adenocarcinoma remains unclear. Prostate cancer cells of varying metastatic potential and apoptotic resistance show altered expression of plasma membrane ion channels and unbalanced Ca2+ homeostasis. Ca(2+)-activated Cl(-) channels (CaCCs) are robustly expressed in epithelial cells and functi...

journal_title：Cancer letters

authors： Liu W,Lu M,Liu B,Huang Y,Wang K

更新日期：2012-12-29 00:00:00

abstract：:CXCR2 and its ligands have been shown to play an important role in tumor angiogenesis, therapy resistance and progression. In this study, we investigated whether CXCR2 ligands are responsible for the survival advantage and metastasis of drug-resistant cells and examined the underlying mechanism(s) doxorubicin or pacli...

journal_title：Cancer letters

authors： Sharma B,Varney ML,Saxena S,Wu L,Singh RK

更新日期：2016-03-28 00:00:00

abstract：:Primary liver cancer is the fifth most common cancer worldwide and hepatocellular carcinoma (HCC) accounts for over 85% of all primary liver cancers. The clinical management of advanced and metastatic HCC is challenging on many counts. Besides largely occurs within a background of underlying chronic liver disease and ...

journal_title：Cancer letters

authors： Hui KM

更新日期：2009-12-01 00:00:00

abstract：:Oncogenic pituitary homeobox 2 (PITX2), a de facto master regulator of developmental organ asymmetry, previously upregulated multidrug resistance (MDR) P-glycoprotein ABCB1 in A498 renal cell carcinoma (RCC) cells. The role of PITX2 isoforms in MDR cancers was investigated. Data mining correlated elevated PITX2 in >30...

journal_title：Cancer letters

authors： Lee WK,Thévenod F

更新日期：2019-05-01 00:00:00

abstract：:Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...

journal_title：Cancer letters

authors： Qiao L,Koutsos M,Tsai LL,Kozoni V,Guzman J,Shiff SJ,Rigas B

更新日期：1996-10-01 00:00:00

abstract：:To clarify the suitability of a newborn-mouse carcinogenesis assay to detect tumor-promoting activities of carcinogens, the non-genotoxic hydroquinone (HQ) and genotoxic 1,1-dimethylhydrazine (UDMH) were administered to mice during the promotion stage after treatment with 1-methyl-1-nitrosourea (MNU) (20 mg/kg body wt...

journal_title：Cancer letters

authors： Tamura T,Shibutani M,Toyoda K,Shoda T,Takada K,Uneyama C,Takahashi M,Hirose M

更新日期：1999-08-23 00:00:00

abstract：:Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...

journal_title：Cancer letters

authors： Yaacoub K,Pedeux R,Tarte K,Guillaudeux T

更新日期：2016-08-10 00:00:00

abstract：:Melanoma antigen A6 (MAGEA6)/TRIM28 complex is a cancer-specific ubiquitin ligase, which degradates tumor suppressor protein AMP-activated protein kinase (AMPK). We show that MAGEA6 is uniquely expressed in human glioma tissues and cells, which is correlated with AMPKα1 downregulation. It is yet absent in normal brain...

journal_title：Cancer letters

authors： Pan SJ,Ren J,Jiang H,Liu W,Hu LY,Pan YX,Sun B,Sun QF,Bian LG

更新日期：2018-01-01 00:00:00

abstract：:Interferon-beta (IFN-β) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-β, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN-β-induced increase in endogenous PML contri...

journal_title：Cancer letters

authors： Okazaki T,Kageji T,Kuwayama K,Kitazato KT,Mure H,Hara K,Morigaki R,Mizobuchi Y,Matsuzaki K,Nagahiro S

更新日期：2012-10-28 00:00:00

abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...

journal_title：Cancer letters

authors： Papadopoulos D,Seidegard J,Rydström J

更新日期：1984-02-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...

journal_title：Cancer letters

authors： Yong X,Tang B,Xiao YF,Xie R,Qin Y,Luo G,Hu CJ,Dong H,Yang SM

更新日期：2016-05-01 00:00:00

abstract：:Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic ...

journal_title：Cancer letters

authors： Mazzoni SM,Fearon ER

更新日期：2014-12-01 00:00:00

abstract：:The guinea pig Kurloff cell (KC) is an estradiol-dependent circulating mononuclear cell that had natural killer cytotoxic activity in vitro. We studied the variation of KC number during the development of transplanted leukemia in inbred strain 2 (S2) leukemia-sensitive guinea pigs. Grafts of leukemic cells (L2C) produ...

journal_title：Cancer letters

authors： Debout C,Taouji S,Izard J

更新日期：1995-10-20 00:00:00

abstract：:NF-kappaB transcription factor regulates important cellular processes ranging from establishment of the immune and inflammatory responses to regulation of cell proliferation or apoptosis, through the induction of a large array of target genes. NF-kappaB is now considered as an important actor in the tumorigenic proces...

journal_title：Cancer letters

authors： Magné N,Toillon RA,Bottero V,Didelot C,Houtte PV,Gérard JP,Peyron JF

更新日期：2006-01-18 00:00:00

abstract：:Bacteria are always a considerable tool for the cancer therapy. The bacteria-derived minicells are re-emerged as a promising drug delivery system for cancer therapy. The minicells are nano-sized, anucleated, non-dividing, and metabolically active cells produced by abnormal bacterial cell division that are able to tran...

journal_title：Cancer letters

authors： Ali MK,Liu Q,Liang K,Li P,Kong Q

更新日期：2020-10-28 00:00:00

abstract：:The NM23 family proteins are involved in a variety of biological processes including tumor metastasis, development, and differentiation; however, their functions in the regulation of cellular proliferation are poorly understood. We have investigated the role of one NM23 family protein, NM23H2, in the regulation of cel...

journal_title：Cancer letters

authors： Lee MY,Jeong WJ,Oh JW,Choi KY

更新日期：2009-03-18 00:00:00

abstract：:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among ...

journal_title：Cancer letters

authors： Guo Y,Chen Y,Liu X,Min JJ,Tan W,Zheng JH

更新日期：2020-01-28 00:00:00

abstract：:Metabolic syndrome (MS) and related disorders, including cancer, are steadily increasing in most countries of the world. However, mechanisms underlying the link between MS and colon carcinogenesis have yet to be fully elucidated. In this review article we focus on the relationships between various individual associate...

journal_title：Cancer letters

authors： Ishino K,Mutoh M,Totsuka Y,Nakagama H

更新日期：2013-06-28 00:00:00