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Reproductive fitness advantage of BCR-ABL expressing leukemia cells.

Abstract：

:Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. We utilize a model of chronic myeloid leukemia (CML), to quantitate the fitness advantage conferred by expression of BCR-ABL in hematopoietic cells from in vivo patient data. We show that BCR-ABL expression provides a high fitness advantage, which explains why this single mutation drives the chronic phase of CML.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Traulsen A,Pacheco JM,Dingli D

doi

10.1016/j.canlet.2010.01.020

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

43-8

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(10)00046-7

journal_volume

294

pub_type

杂志文章

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