Abstract：
:The effect of the naturally occurring flavonol, quercetin, was investigated on cell growth and metabolism of two human carcinoma cell lines, HT29 and Caco-2 cells, both during the exponentially growing phase and after confluence. Our results show clearly that, after a 48-h period of treatment, quercetin (in the range of concentration from 15 microM to 120 microM) exerted a preferential cytotoxic effect on active proliferating cells. This effect was dose dependent and was accompanied by a simultaneous inhibition of lactate release and a dramatic decrease of total cellular ATP content. In contrast, in confluent cells, quercetin failed to affect cell viability or lactate release, but led nevertheless to a depletion of cellular ATP level. In conclusion, the cytotoxicity of quercetin is markedly higher in actively growing cells in comparison with confluent cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Agullo G,Gamet L,Besson C,Demigné C,Rémésy Cdoi
10.1016/0304-3835(94)90409-xsubject
Has Abstractpub_date
1994-11-25 00:00:00pages
55-63issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(94)90409-Xjournal_volume
87pub_type
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