Abstract:
:Twenty C57BL/6 male and 20 C3H female mice carrying a methyl cholanthrene-induced fibrosarcoma received, daily, intraperitoneal injections of histamine dihydrochloride (1.8 mg or 6 mg histamine base/mouse). In all histamine-treated C57BL/6 mice, tumour growth was significantly slower than in control mice until day 18. Thereafter, the tumour growth rate of treated compared to control mice was accelerated. In 10 out of 20 C3H mice, tumour growth was significantly slower until day 25; in histamine responsive C3H mice, histological studies showed numerous and large loci of acute haemorrhagic necrosis in the tumours.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Burtin C,Scheinmann P,Salomon JC,Lespinats G,Loisillier F,Canu Pdoi
10.1016/0304-3835(81)90068-9subject
Has Abstractpub_date
1981-04-01 00:00:00pages
195-201issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(81)90068-9journal_volume
12pub_type
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