Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects.

abstract：:Cyclooxygenase-2 (COX-2) is a transcriptional target and downstream effector of the ErbB-1 (EGFR) and ErbB-2 signaling pathways. We found that anti-EGFR and anti-ErbB-2 antibodies inhibited ERK phosphorylation and downregulated COX-2 protein expression in HCA-7 human colon carcinoma cells. Both antibodies also augment...

journal_title：Cancer letters

authors： Half E,Sun Y,Sinicrope FA

更新日期：2007-06-28 00:00:00

abstract：:Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...

journal_title：Cancer letters

authors： Neal GE,Legg RF

更新日期：1983-11-01 00:00:00

abstract：:In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma (RMS) and med...

journal_title：Cancer letters

authors： Meister MT,Boedicker C,Linder B,Kögel D,Klingebiel T,Fulda S

更新日期：2019-11-28 00:00:00

abstract：:Diet-induced changes in serum cholesterol levels and their relationship to mammary carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were studied in female Sprague-Dawley rats. DMBA was given to rats subjected to 3 dietary treatments: (1) a semipurified, cholesterol-free diet (SP); (2) the same diet wi...

journal_title：Cancer letters

authors： Klurfeld DM,Kritchevsky D

更新日期：1981-12-01 00:00:00

abstract：:The preparation of chlorophyllin copper complex (CCC), shown to be a tumor promoter in an animal model (Nelson, R.L. (1992) Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737-740), also inhibits the activities of direct- and indirec...

journal_title：Cancer letters

authors： Chernomorsky S,Rancourt R,Virdi K,Segelman A,Poretz RD

更新日期：1997-12-09 00:00:00

abstract：:Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Thus, in the current study, the ability of LIM and other monoterpe...

journal_title：Cancer letters

authors： Morse MA,Toburen AL

更新日期：1996-07-12 00:00:00

abstract：:The levels of 26 kDa-soluble (S) and 30 kDa-membrane-bound (MB) catechol-O-methyltransferase (COMT) polypeptides were determined in paired samples from normal and neoplastic breast tissue of 32 patients with breast cancer. Immunohistochemical staining showed that the COMT reaction in normal mammary tissue was restrict...

journal_title：Cancer letters

authors： Tenhunen J,Heikkilä P,Alanko A,Heinonen E,Akkila J,Ulmanen I

更新日期：1999-09-20 00:00:00

abstract：:Previous studies have demonstrated that fibroblast growth factor 8b (FGF8b) is up-regulated in a large proportion of prostate cancer patients and that it plays a key role in prostate carcinogenesis. In this study, we designed and synthesized a gN helix domain derived short peptide (termed 8b-13) based on the analysis ...

journal_title：Cancer letters

authors： Li T,Luo W,He D,Wang R,Huang Y,Zeng X,Wang W,Chen X,Gao S,Yu Y,Li X,Wu X

更新日期：2013-10-10 00:00:00

abstract：:Tocopherol, a well known tissue anti-oxidant, given before local X-ray irradiation of 2 transplantable rat tumours was previously found to increase significantly the effect of irradiation. In the present study tocopherol did not influence the development of tumour necroses during growth of a transplantable rat hepatom...

journal_title：Cancer letters

authors： Kågerud A,Klintenberg C,Lund N,Peterson HI

更新日期：1978-10-01 00:00:00

abstract：:Pancreatic cancer cells are usually resistant to apoptosis mediated by tumor necrosis factor (TNF)-alpha or FasL, and their toxicity towards normal cells hampers their application for therapeutic use. TNF-related apoptosis-inducing ligand (TRAIL), a novel member of the TNF family, triggers apoptosis in a variety of ma...

journal_title：Cancer letters

authors： Ozawa F,Friess H,Kleeff J,Xu ZW,Zimmermann A,Sheikh MS,Büchler MW

更新日期：2001-02-10 00:00:00

abstract：:Exosomes are biological nanovesicles that are involved in cell-cell communication via the functionally-active cargo (such as miRNA, mRNA, DNA and proteins). Because of their nanosize, exosomes are explored as nanodevices for the development of new therapeutic applications. However, bulk, safe and cost-effective produc...

journal_title：Cancer letters

authors： Munagala R,Aqil F,Jeyabalan J,Gupta RC

更新日期：2016-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Many kinases have been found to be intimately involved in oncogenesis and the deregulation of kinase function has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and surviv...

journal_title：Cancer letters

authors： Xia H,Kong SN,Chen J,Shi M,Sekar K,Seshachalam VP,Rajasekaran M,Goh BKP,Ooi LL,Hui KM

更新日期：2016-12-01 00:00:00

abstract：:Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA-DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA signif...

journal_title：Cancer letters

authors： Cheng CL,Chen KJ,Shih PH,Lu LY,Hung CF,Lin WC,Yesong Gu J

更新日期：2006-02-08 00:00:00

abstract：:The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids ...

journal_title：Cancer letters

authors： Kozuki Y,Miura Y,Yagasaki K

更新日期：2000-04-03 00:00:00

abstract：:The biological characteristic cell locomotion and invasion, melanin content, metalloproteinases and telomerase activity were studied in a parental mouse melanoma cell line B16 and two descendents B16BL6 and B16F10. The invasive potential of melanoma cells was assayed in a transwell cell culture chamber. Melanin conten...

journal_title：Cancer letters

authors： Zhao W,Liu H,Xu S,Entschladen F,Niggemann B,Zänker KS,Han R

更新日期：2001-01-01 00:00:00

abstract：:The effect of the peptide hormone insulin upon the differentiation of a 10T1/2-derived preadipocytic line was found to display a potent time-dependence. Insulin addition before cell confluence strongly enhanced differentiation, while addition after confluence had no effect. In keeping with the role of c-Ras as a downs...

journal_title：Cancer letters

authors： Preston T,Brownell H,Raptis L

更新日期：1997-05-19 00:00:00

abstract：:Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and re...

journal_title：Cancer letters

authors： Ishimwe N,Zhang W,Qian J,Zhang Y,Wen L

更新日期：2020-04-10 00:00:00

abstract：:The susceptibility of pepsinogen-altered pyloric glands (PAPG) and neoplastic glandular stomach lesions induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and catechol or sodium cholate in Nagase analbuminemic rats (NAR) was compared to Sprague-Dawley rats (SD). Male NAR and SD rats were given a single dose of 80 m...

journal_title：Cancer letters

authors： Ogawa K,Shichino Y,Tatematsu M,Furihata C,Asamoto M,Nagase S,Shirai T,Ito N

更新日期：1995-09-25 00:00:00

abstract：:Male and female transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) received three subcutaneous injections of 0.3 mg N-methyl-N-nitrosourethane (MNUR) once every 2 weeks for the first 4 weeks followed by a single intraperitoneal injection of 1000 or 0 mg/kg ...

journal_title：Cancer letters

authors： Mitsumori K,Yasuhara K,Mori I,Hayashi S,Shimo T,Onodera H,Nomura T,Hayashi Y

更新日期：1998-07-17 00:00:00

abstract：:Loss of radioactivity from nude mice was determined after inoculation of human tumor cells prelabeled with [111In]indium oxine (111InOx). Elimination of 111In was increased somewhat by treating the mice with diphtheria toxin (DT), which is toxic selectively for human cells compared to mice. Calcium disodium edetate (C...

journal_title：Cancer letters

authors： Lockshin A,Giovanella BC,Kozielski T,Stehlin JS Jr

更新日期：1984-09-01 00:00:00

abstract：:Exosomes are structurally and functionally pleiotropic nano-sized (~30-150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication and bio-waste disposal. To a great extent, exosomes represent biologi...

journal_title：Cancer letters

authors： Kumar A,Deep G

更新日期：2020-09-28 00:00:00

abstract：:Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...

journal_title：Cancer letters

authors： Pärssinen J,Alarmo EL,Khan S,Karhu R,Vihinen M,Kallioniemi A

更新日期：2008-01-18 00:00:00

abstract：:The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...

journal_title：Cancer letters

authors： Liu TY,Hwua YS,Chao TW,Chi CW

更新日期：1995-03-02 00:00:00

abstract：:The tumor promoter, phorbol-12-myristate-13-acetate (PMA), elicited a significant increase in lysosomal membrane permeability, as measured by release of free beta-glucurnidase, in guinea pig and hamster isolated hepatic lysosomes in vitro. This response was antagonized by zinc sulfate; zinc compounds having previously...

journal_title：Cancer letters

authors： Pfeiffer CJ,Cho CH

更新日期：1980-07-01 00:00:00

abstract：:Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated w...

journal_title：Cancer letters

authors： Jian Y,Wang M,Zhang Y,Ou R,Zhu Z,Ou Y,Chen X,Liang X,Ding Y,Song L,Xu X,Liao W

更新日期：2018-08-01 00:00:00

abstract：:A hepatic mixed-function oxygenase system gave enhanced biphenyl 2-hydroxylation in the presence of known carcinogens in vitro and was therefore suggested as a convenient short-term assay for the detection of potentially dangerous compounds. However, the test did not yield the expected increase of biphenyl 2-hydroxyla...

journal_title：Cancer letters

authors： McPherson F,Kolar GF

更新日期：1979-01-01 00:00:00

abstract：:Data were obtained on soluble oestrogen (ER) and progesterone (PR) receptors from 273 primary breast tumours, using an enzyme immunoassay (EIA) and ligand binding assay with dextran-coated charcoal (DCC) or isoelectric focussing separations. The p29 and total cathepsin D content was also assayed in the same samples. T...

journal_title：Cancer letters

authors： Marsigliante S,Greco S,Biscozzo L,Barker S,Baker V,Giuseppe L,Vinson GP,Storelli C

更新日期：1992-10-21 00:00:00

abstract：:The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...

journal_title：Cancer letters

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1995-08-16 00:00:00

abstract：:Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...

journal_title：Cancer letters

authors： Zi Xu YX,Ande SR,Mishra S

更新日期：2018-02-28 00:00:00

abstract：:Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 homologs have been reported according to their sequence homology to the yeast Saccharomyces cerevisiae (Sc) Atg4. Accumulating evidence ha...

journal_title：Cancer letters

authors： Zhang L,Li J,Ouyang L,Liu B,Cheng Y

更新日期：2016-04-01 00:00:00