Abstract:
:Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibitory effect is possibly mediated by a cAMP-dependent activation of the small GTPase Rap1 via Epac. Furthermore, a key signalling event of the promigratory effect of norepinephrine in the above mentioned carcinoma cells is the activation of phospholipase C enzymes. In ES-2 cells, this part of the signalling cascade is constitutively active.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Bastian P,Balcarek A,Altanis C,Strell C,Niggemann B,Zaenker KS,Entschladen Fdoi
10.1016/j.canlet.2008.09.008subject
Has Abstractpub_date
2009-02-18 00:00:00pages
218-24issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00720-9journal_volume
274pub_type
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