Abstract:
:Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor cells. Our conclusions are supported by morphological and molecular changes induced in teLEC that in turn enhance cancer cell invasion in 3D cultures and tumor cell proliferation in vivo. The characterization of teLEC secretome by RNA-Sequencing and cytokine array revealed that interleukine-6 (IL6) is one of the most modulated molecules in teLEC, whose production was negligible in unexposed LEC. Notably, neutralizing anti-human IL6 antibody abrogated teLEC-mediated mitogenic effects in vivo, when LEC were mixed with tumor cells in the ear sponge assay. We here assign a novel function to teLEC that is beyond their role of lymphatic vessel formation. This work highlights a new paradigm, in which teLEC exert "fibroblast-like properties", contribute in a paracrine manner to the control of tumor cell properties and are worth considering as key stromal determinant in future studies.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Van de Velde M,Ebroin M,Durré T,Joiret M,Gillot L,Blacher S,Geris L,Kridelka F,Noel Adoi
10.1016/j.canlet.2020.10.020subject
Has Abstractpub_date
2021-01-28 00:00:00pages
154-164eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30546-2journal_volume
497pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90141-6
更新日期:1983-05-01 00:00:00
abstract::The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.12.010
更新日期:2008-04-08 00:00:00
abstract::Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers and can be transcriptionally regulated by various ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.01.036
更新日期:2020-04-28 00:00:00
abstract::In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein--Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00521-3
更新日期:2001-08-10 00:00:00
abstract::5-FU is commonly used for treatment of various solid tumors including colon carcinoma. We have previously demonstrated that Egr-1 induced by 5-FU enhanced TSP-1 expression in human colon cancer KM12C cells. In this study, a Genechip analysis of KM12C cells treated with 5-FU revealed down-regulation of 924 genes and up...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.04.045
更新日期:2008-10-18 00:00:00
abstract::Gastric adenocarcinoma and esophageal adenocarcinoma are aggressive cancers with a poor prognosis. Therefore, new therapeutic strategies are needed, especially for patients refractory to conventional treatment. Cancer immunotherapy (CIT), is a promising new treatment option and is effective in a proportion of patients...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.11.001
更新日期:2019-02-01 00:00:00
abstract::The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90075-1
更新日期:1982-01-01 00:00:00
abstract::Pancreatic cancer cells are usually resistant to apoptosis mediated by tumor necrosis factor (TNF)-alpha or FasL, and their toxicity towards normal cells hampers their application for therapeutic use. TNF-related apoptosis-inducing ligand (TRAIL), a novel member of the TNF family, triggers apoptosis in a variety of ma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00660-1
更新日期:2001-02-10 00:00:00
abstract::Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90189-1
更新日期:1983-08-01 00:00:00
abstract::Chromosome 22q shows a high frequency of loss of heterozygosity (LOH) in ovarian cancers suggesting the existence of one or more important tumor suppressor genes (TSGs). The tissue inhibitor of metalloproteinase-3 (TIMP-3) is a plausible TSG candidate since it is often encompassed within these regions of LOH. TIMP-3 h...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.03.024
更新日期:2007-03-08 00:00:00
abstract::EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs207511...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.008
更新日期:2015-02-28 00:00:00
abstract::Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.01.003
更新日期:2013-05-01 00:00:00
abstract::Numbers of circulating endothelial cells (CECs) are increased in cancer patients with progressive disease. Also, cancer patients have an increased risk for thrombotic events, being negatively associated with prognosis. Tissue factor (TF), the physiological initiator of coagulation, is present on the surface of many ex...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.019
更新日期:2004-09-30 00:00:00
abstract::Sulfasalazine (SSZ) is an anti-inflammatory drug that has been demonstrated to induce apoptosis and tumor regression through inhibition of plasma membrane cystine transporter xc(-). Cysteine is a rate-limiting precursor for intracellular glutathione (GSH) synthesis, which is vital for compound detoxification and maint...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.07.031
更新日期:2015-11-01 00:00:00
abstract::In the course of screening for a novel inhibitor of cyclin-dependent kinase (CDK), HY52 (C17H30O2N2; molecular weight 294) was isolated from the leaves of Pata de Vaca (Bauhinia forficata). The growth of HeLa cells was inhibited in a dose-dependent manner when treated with 0.07 to 0.41 mM of HY52 for 24 h (IC50:0.11 m...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.03.002
更新日期:2006-02-20 00:00:00
abstract::The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, leading to the substitu...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90073-i
更新日期:1993-06-15 00:00:00
abstract::The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.04.025
更新日期:2009-11-01 00:00:00
abstract::The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5. T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.08.012
更新日期:2005-04-18 00:00:00
abstract::Consumption of false morel (Gyromitra esculenta Fr.) has been associated not only with acute poisoning, but also with a carcinogenic risk. The hydrolysis of acetaldehyde-N-methyl-N-formylhydrazone (gyromitrin, the main toxic component of false morel) results in the formation of the methylating agents N-methyl-N-formyl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90175-u
更新日期:1992-01-10 00:00:00
abstract::To estimate the contents of flavonoids in the Danish diet, we have used a high performance liquid chromatographic method for the analysis of fruits, vegetables and beverages. The flavonoid contents were quantified, and the observations were verified by mass spectrometry. The investigation is not completed, but we are ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)04651-x
更新日期:1997-03-19 00:00:00
abstract::Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.05.012
更新日期:2017-08-28 00:00:00
abstract::The aim of this study was to clarify candidate peptides for peptide-based specific immunotherapy of patients with oral squamous cell carcinoma (SCC). Thirteen peptides were examined for in vitro induction of peptide-specific CD8(+) T lymphocyte (CD8(+)TL) activity in peripheral blood mononuclear cells from 35 patients...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.02.016
更新日期:2012-09-01 00:00:00
abstract::Our earlier studies have shown that simultaneous inhibition of glycolysis and pentose phosphate pathway using 2-deoxy-d-glucose (2-DG, an inhibitor of glycolysis) and 6-aminonicotinamide (6-AN, an inhibitor of pentose phosphate pathway) lead to metabolic oxidative stress (MOS), resulting in radiosensitization in malig...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.02.021
更新日期:2010-09-28 00:00:00
abstract::Microarray analysis is a powerful technology, but its impact on routine diagnosis for the near future maybe in revealing individual genes, which are useful diagnostic markers. Recently microarray analysis has identified a novel subgroup of childhood precursor-B acute lymphoblastic leukaemia (ALL) from a unique gene ex...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.11.012
更新日期:2006-10-28 00:00:00
abstract::A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90025-3
更新日期:1983-10-01 00:00:00
abstract::In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)03722-u
更新日期:1995-05-04 00:00:00
abstract::HER2 positive breast cancers have been shown to have a greater propensity to metastasise to the brain. This may be due to several reasons, including the creation of a "sanctuary-site" for tumour in the brain following trastuzumab therapy. Elucidating the mechanism of this phenomenon may aid the prevention or intervent...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.12.026
更新日期:2015-03-28 00:00:00
abstract::gamma-Glutamyltranspeptidase (gamma-GTP) activity was found in a human pancreatic cancer cell line, HPC-Y1, cultivated in a serum-free chemically defined medium. The gamma-GTP stained in the cytoplasms as fine granules and was produced constantly in a protein-free chemically defined medium. The detergent- or protease-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(84)80037-3
更新日期:1984-12-01 00:00:00
abstract::Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.07.033
更新日期:2006-07-28 00:00:00
abstract::The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90045-0
更新日期:1987-05-01 00:00:00