Abstract:
:Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research community is the systematic functional characterization of these genetic and epigenetic events to assess their role in cancer initiation and progression. Recent advances in genome engineering using CRISPR/Cas9, an ancient bacterial immune-like system, have revolutionized cancer genetics. Here we highlight the breakthroughs in the effective use of these novel genome-editing techniques, and we discuss the challenges and potential applications of these tools for cancer biology.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Sayin VI,Papagiannakopoulos Tdoi
10.1016/j.canlet.2016.03.029subject
Has Abstractpub_date
2017-02-28 00:00:00pages
10-17eissn
0304-3835issn
1872-7980pii
S0304-3835(16)30179-3journal_volume
387pub_type
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