Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.

Abstract:

:We previously showed that polyphyllin D (PD) produced a stronger apoptotic effect in R-HepG2 with multi-drug resistance (MDR) than that in its parent HepG2 cells without MDR. In this study, PD was found to elicit mitochondrial fragmentation in live cells by using total internal reflection fluorescence microscopy (TIRFM). When mitochondria were isolated and treated directly with PD, a stronger swelling, deeper transmembrane depolarization, and more apoptosis-inducing factor (AIF) release were observed from the mitochondria of R-HepG2 than that of HepG2. These observations suggest that PD is a potent anti-cancer agent that bypasses MDR and elicits apoptosis via mitochondrial injury.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Ong RC,Lei J,Lee RK,Cheung JY,Fung KP,Lin C,Ho HP,Yu B,Li M,Kong SK

doi

10.1016/j.canlet.2007.11.005

subject

Has Abstract

pub_date

2008-03-18 00:00:00

pages

158-64

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00551-4

journal_volume

261

pub_type

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