Abstract:
:We previously showed that polyphyllin D (PD) produced a stronger apoptotic effect in R-HepG2 with multi-drug resistance (MDR) than that in its parent HepG2 cells without MDR. In this study, PD was found to elicit mitochondrial fragmentation in live cells by using total internal reflection fluorescence microscopy (TIRFM). When mitochondria were isolated and treated directly with PD, a stronger swelling, deeper transmembrane depolarization, and more apoptosis-inducing factor (AIF) release were observed from the mitochondria of R-HepG2 than that of HepG2. These observations suggest that PD is a potent anti-cancer agent that bypasses MDR and elicits apoptosis via mitochondrial injury.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ong RC,Lei J,Lee RK,Cheung JY,Fung KP,Lin C,Ho HP,Yu B,Li M,Kong SKdoi
10.1016/j.canlet.2007.11.005subject
Has Abstractpub_date
2008-03-18 00:00:00pages
158-64issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(07)00551-4journal_volume
261pub_type
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