abstract：:The microbial transformation of androst-4-ene-3,17-dione (4-AD; I) by three fungal species, involved Fusarium solani BH1031, Aspergillus awamori MH18 and Mucor circinelloides W12, has been studied. The latter two fungi were studied for the first time on biotransformation of 4-AD. The main product obtained by Fusarium ...

journal_title：Natural product research

authors： An X,Gao P,Zhao S,Zhu L,You X,Li C,Zhang Q,Shan L

更新日期：2021-02-01 00:00:00

abstract：:Investigations were performed on the determination of the main components in Berchemia lineata (L.) DC. (BL) and its metabolism with human liver microsomes (HLM). A total of 35 compounds were detected in BL extracts and 25 of them including 6 naphthopyrones, 10 flavonoids, 2 phenolic acids, 2 phenols, 4 fatty acids an...

journal_title：Natural product research

authors： Jiang X,Chen S,Guo Z,Gu D,Liang X

更新日期：2021-02-01 00:00:00

abstract：:Cochliomycin G (1), a new 14-membered resorcylic acid lactone, together with six known analogues (2-7), was isolated from the culture broth of a marine-derived fungus Cochliobolus lunatus. The planar structure of 1 was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the comb...

journal_title：Natural product research

authors： Xu WF,Xue XJ,Qi YX,Wu NN,Wang CY,Shao CL

更新日期：2021-02-01 00:00:00

abstract：:To search for antifungal leads, the metabolites of an insect-derived fungus Fusarium lateritium ZMT01 were investigated, providing five sesquiterpenes (1-5), including new molecules microsphaeropsisins D and E (1 and 2). The evaluated antifungal activities in vitro which are higher than the positive control triadimefo...

journal_title：Natural product research

authors： Zhu J,Xiong P,Li Z,Li J,Lin L,Fu X,Huang Y,Xiong Y,Li C

更新日期：2021-01-15 00:00:00

abstract：:Herein we report the regioselective synthesis of podophyllotoxin-Glycosyl triazole hybrids catalysed by Ag(I)-N-heterocyclic carbene (Ag(I)-NHC) in a short reaction time (∼30 min) at ambient conditions. In principle, it is the first report of Click alkyne-azide cycloaddition catalysed by Ag(I)-NHC catalyst and moreove...

journal_title：Natural product research

authors： Nerella S,Kankala S,Gavaji B

更新日期：2021-01-01 00:00:00

abstract：:Teaghrelins, identified originally in Chin-shin oolong tea, are unique acylated flavonoid tetraglycosides and proposed to be potential oral analogues of ghrelin. In the present study, two new teaghrelin-like compounds were characterized from tea cultivars (TTES No. 12), and their chemical structures were established b...

journal_title：Natural product research

authors： Kuo PC,Li YC,Wu RH,Tzen JTC

更新日期：2021-01-01 00:00:00

abstract：:The importance of the present study is to find out the phytochemical profile of essential oil (EO) of Artemisia tournefortiana Reichb. and its biological evaluation. Nineteen volatile constituents were identified from EO representing 93.47% of total oil composition. Oxygenated monoterpenes (54.46%) were found to be do...

journal_title：Natural product research

authors： Qadir M,Maurya AK,Agnihotri VK,Shah WA

更新日期：2021-01-01 00:00:00

abstract：:The proposed work, aims to provide a "green" and cutting-edge technique for the mordanting and dyeing of polyester fabric with natural henna dye using the advanced technology of micro waves. For providing a complete "green" and ecofriendly dyeing process, lemon was used as a natural bio mordant with micro waves and re...

journal_title：Natural product research

authors： Arain RA,Ahmad F,Khatri Z,Peerzada MH

更新日期：2021-01-01 00:00:00

abstract：:Novel derivatives of 4-oxo-3-methylcytisine with phenyl moiety bonded to starting molecule through various spacers were obtained from the 9-amino, -halo, -formyl and 11-halo precursors by reductive alkylation of amines, generation of amide, as well as thio- and carboxamide functions, cross-coupling reactions, aldehyde...

journal_title：Natural product research

authors： Tsypysheva I,Petrova P,Koval'skaya A,Lobov A,Sapozhnikova T,Makara N,Gabdrakhmanova S,Zarudii F

更新日期：2021-01-01 00:00:00

abstract：:The objective of this work was to produce and characterise nanoemulsions containing tucumã extract and to evaluate the performance of the nanostructure and the free compound regarding antitumor activity, cytotoxicity, and oxidative metabolism in NB4/APL cells. The nanoemulsions showed adequate physicochemical characte...

journal_title：Natural product research

authors： Copetti PM,Gündel SDS,de Oliveira PSB,Favarin FR,Ramos AP,Pintos FG,Pappis L,Gündel A,Machado AK,Ourique AF,Sagrillo MR

更新日期：2020-12-24 00:00:00

abstract：:A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of β-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a...

journal_title：Natural product research

authors： Simonovic M,Mix T,Glumac M,Pejin B

更新日期：2020-12-18 00:00:00

abstract：:Phytochemical investigation of Eucommia ulmoides Oliver staminate flowers provided twenty-seven compounds, including 11 triterpenes (1-11), 4 fatty acids (12-15), 1 coumarin (16), 1 chromone (17), 7 flavonoids (18-24) and 3 cyclopeptide alkaloids (25-27). Compounds 4-6, 8-9, 11-15, 17 and 25-27 were reported for the f...

journal_title：Natural product research

authors： Li R,Nie L,Wang Q,Ouyang D,Zhang L,Yuan Y,Hong Y,Wang J,Hu X

更新日期：2020-12-12 00:00:00

abstract：:Two new iridoids namely valerialloside A and valerianoside A (1 and 2) along with five known compounds (3-7) were isolated from the roots of Valeriana jatamansi Jones. The structure of new compounds were determined using 1D and 2D NMR including 1H-1H COSY, HSQC, HMBC and NOESY spectroscopic techniques. ...

journal_title：Natural product research

authors： Maurya AK,Kumar A,Agnihotri VK

更新日期：2020-12-09 00:00:00

abstract：:This study was carried out to investigate the biomedicinal potential of aqueous extract (1.25 and 2.5%) of three henna ecotypes (Shahdad, Roodbar and Bam) against Two types of Gram positive and negative bacteria, Staphylococcus aureus (ATCC 25923), Streptococcus agalactiae (ATCC 29933), Bacillus cereus (ATCC 14579), C...

journal_title：Natural product research

authors： Pasandi Pour A,Farahbakhsh H

更新日期：2020-12-01 00:00:00

abstract：:Two novel natural metabolites, 3-O-butyl-(-)-epicatechin (1) and 3-O-butyl-(-)-epigallocatechin (2), as well as several known substances, (-)-epicatechin (3), (+)-gallocatechin (4), (-)-epigallocatechin (5), azadirachtin A (6), trilinolein (7) and octadecanoic acid-tetrahydrofuran-3,4-diyl ester (8), were isolated fro...

journal_title：Natural product research

authors： Cen-Pacheco F,Ortiz-Celiseo A,Peniche-Cardeña A,Bravo-Ruiz O,López-Fentanes FC,Valerio-Alfaro G,Fernández JJ

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the phenolic contents in capsule and root methanolic extracts of Euphorbia retusa followed by identification of phenolic on capsule extracts through high-performance liquid chromatography (HPLC- DAD) for the first time. Likewise, the antioxidant activity of both extracts wa...

journal_title：Natural product research

authors： Lahmadi S,Belhamra M,Karoune S,Imad K,Bensouici C,Kechebar MSA,Halis Y,Ksouri R

更新日期：2020-12-01 00:00:00

abstract：:The chemical composition of the methanol extract obtained from Araucaria cunninghamii Sweet. bark was determined by GC-MS analysis with its antioxidant and antibacterial potential, for the first time. A total of 73 compounds were identified and the extract was strongly characterised by Viridiflorene; Androstan-17-one,...

journal_title：Natural product research

authors： Kumar P,Sati SC,Khulbe K,Pant P,Tripathi AN,Sarvendra K

更新日期：2020-11-29 00:00:00

abstract：:Pigeon Pea is a well-received traditional nutritious and medicinal plant in India since ancient times. The plant is identified for its impressive pharmacological activities like antimicrobial, anti-inflammatory, antitubercular, antioxidant, neuroprotective, antihypertensive, antihyperglycemic and anticancer properties...

journal_title：Natural product research

authors： Dinore JM,Farooqui M

更新日期：2020-11-23 00:00:00

abstract：:Physalis angulata is an annual herb which has tremendous medicinal uses. The antioxidant activity of the whole plant extract of Physalis angulata was investigated using DPPH radical scavenging activity. Purified compounds were isolated using column chromatography method. Their structures were determined using various ...

journal_title：Natural product research

authors： Odusina BO,Onocha PA

更新日期：2020-11-23 00:00:00

abstract：:Two new fatty acid esters of triterpenoids (1-2) together with eleven known compounds (3-13) were obtained after investigation of the CH2Cl2-MeOH (1:1) crude extract from the leaves of Schefflera barteri Harms. All these compounds (1-13) were isolated for the first time from this plant among which compounds 3, 4, 6 an...

journal_title：Natural product research

authors： Mbougnia JFT,Bitchagno GTM,Wouamba SCN,Jouda JB,Awouafack MD,Tene M,Lenta BN,Kouam SF,Tane P,Sewald N

更新日期：2020-11-18 00:00:00

abstract：:The phytochemical constituents in the aqueous methanolic leaf extract of Triclisia gilletii responsible for its nephroprotective potentials against ethane-1,2-diol induced nephrolithiasis as previously investigated in our laboratory were elucidated. The extract was prepared using 80% aqueous methanol in 72 h, Phytoche...

journal_title：Natural product research

authors： Olayeriju OS,Papetti A,Colombo R,Mannucci B,Olaleye MT,Akindahunsi AA

更新日期：2020-11-12 00:00:00

abstract：:This paper aims to investigate, for the first time, physicochemical characteristics and antioxidant capacity of Psidium myrtoides ripe and unripe fruit. In addition, essential oil was extracted from fresh leaves (PM-EO) collected in dry and rainy seasons to investigate the influence of seasonality and, after that, to ...

journal_title：Natural product research

authors： Dias ALB,Batista HRF,Sousa WC,Bailão EFLC,Rocha JD,Sperandio EM,Fernandes CC,Souchie EL,Miranda MLD

更新日期：2020-11-09 00:00:00

abstract：:This study aimed at evaluating the impact of environmental factors on the accumulation of various components in Hedera helix L. folium collected from different European countries. The obtained results of studied samples showed that the antioxidant capacities were in the range of 0.027 to 0.688 mg/g. Contents of active...

journal_title：Natural product research

authors： Bezruk I,Materiienko A,Gubar S,Proskurina K,Budanova L,Ivanauskas L,Georgiyants V

更新日期：2020-11-04 00:00:00

abstract：:Two new sesquiterpenoid glycosides as dihydrophaseic acid 4'-O-[6″-O-(4″'-hydroxy-3″', 5″'-dimethoxy) benzoyl)]-β-D-glucopyranoside (1) and dihydrophaseic acid 4'-O-[6″-O-(3″'-methoxy- 4″'-hydroxy) benzoyl)]-β-D-glucopyranoside (2), were isolated from the stems of Zanthoxylum armatum in the study. The compound 1 and 2...

journal_title：Natural product research

authors： Liu YL,Gao LL,Song TT,Guo T,Chang J

更新日期：2020-11-01 00:00:00

abstract：:Two new chromones, spororrminone A (1, (S)-5-hydroxy-2-methyl-4-oxo-2-((S)-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid) and 2-epi-spororrminone A (2, (R)-5-hydroxy-2-methyl-4-oxo-2-((S)-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid), were isolated from an EtOAc extract of an endolichenic fungal strain Sp...

journal_title：Natural product research

authors： Huang MJ,Li YJ,Tang J,Chen GD,Hu D,Xu W,Guo LD,Yao XS,Gao H

更新日期：2020-11-01 00:00:00

abstract：:Six compounds were isolated from the stems and leaves of Arachis hypogaea, including a new norsesquiterpene, arahyside A (1), and five known compounds, 4-(2-methoxyethyl)benzene-1,2-diol (2), (1(R,S),2(R,S))-1-phenylpropane-1,2-diol (3), tachioside (4), 1,3-benzenediol (5), demethylmedicarpin (6). Extensive spectrosco...

journal_title：Natural product research

authors： Jin WF,Luo ZH,Sun YP,Liu JS,Yu Y,Wang G,Wang GK

更新日期：2020-11-01 00:00:00

abstract：:Jatropha mutabilis (Pohl) Baill is an endemic species of the Caatinga biome, little studied in terms of chemical composition. The objective of this work was to develop an analytical methodology to quantify vitexin in the ethanolic extract of J. mutabilis and to evaluate the expectorant and antitussive activities in mi...

journal_title：Natural product research

authors： Costa EC,Menezes PMN,Silva FS,Ribeiro LAA,Rolim LA,Araújo ECDC,Nunes XP

更新日期：2020-10-30 00:00:00

abstract：:Two novel secondary metabolites, including one thujopsene-type sesquiterpene designated thujasutchin N (1) and one norlignan named thujasutchin O (2) were obtained from the ethanolic extract of the stems and roots of Thuja sutchuenensis. Among them, thujasutchin O (2) represents the first example of lignan sharing a u...

journal_title：Natural product research

authors： Wang M,Huo L,Liu H,Zhao L,Xu Z,Tan H,Qiu SX

更新日期：2020-10-23 00:00:00

abstract：:A new highly oxygenated germacranolide, carcerlane A (1), together with four known highly oxygenated germacranolides (2-5), was isolated from an ethanol extract of the whole plant of Carpesium nepalense var. lanatum (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectrosc...

journal_title：Natural product research

authors： Yu YF,Li YQ,Wang RY,Liu X,Cui WB,Chen XH,Zhao CM,Qi FM,Zhang ZX,Fei DQ

更新日期：2020-10-22 00:00:00

abstract：:The present study was aimed to isolate active constituents from Blumea axillaris (Lam.) DC (Asteraceae) against phytopathogenic fungi. Bioactivity guided fractionation of the successive n-hexane, chloroform and methanol extract led to the isolation of the monoterpene ester (4 R,5S)-4-hydroxy-7-tigloyloxycarvotanaceton...

journal_title：Natural product research

authors： Sivanandhan S,Pathalam G,Antony S,Michael GP,Balakrishna K,Boovaragamurthy A,Shirota O,Alwahibi MS,El-Shikh MS,Ignacimuthu S

更新日期：2020-10-16 00:00:00

abstract：:The oral squamous cell carcinoma (OSCC) is the eighth more common cancer in men. The development of new and more efficient drugs is needed. Plants of the genus Piper are popularly used in the treatment of many diseases. This study evaluated the antitumor effect of extract, fraction and isolated compounds from leaves o...

journal_title：Natural product research

authors： Fonseca ACCD,de Queiroz LN,Sales Felisberto J,Jessé Ramos Y,Mesquita Marques A,Wermelinger GF,Pontes B,de Lima Moreira D,Robbs BK

更新日期：2020-10-14 00:00:00

abstract：:Synsepalum dulcifificum is an evergreen shrub native of tropical West Africa. It is very effective against a variety of diseases. However, the phytochemical investigation on this plant is limited till now. In our current study, seventeen compounds were isolated and identified from the ethyl acetate extract of the leav...

journal_title：Natural product research

authors： Wang J,Shao S,Huang R,Wu S

更新日期：2020-10-09 00:00:00

abstract：:Two phytotoxic furan derivatives were isolated, together with the well-known fungal and plant phytotoxin tyrosol, from the culture filtrates of Stilbocrea macrostoma. This fungal pathogen isolated from Quercus brantii trees induced wood necrosis and decline symptoms on the host plant in Iran. The two furan derivatives...

journal_title：Natural product research

authors： Di Lecce R,Bashiri S,Masi M,Alioto D,Tuzi A,Abdollahzadeh J,Evidente A

更新日期：2020-10-05 00:00:00

abstract：:One new xanthone, chryxanthone C (1), together with four known analogues (2-5), were isolated from the cultures of Paecilamyces sp. TE-540, an endophytic fungus obtained from the leaves of Nicotiana tabacum L. The structure of 1 was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which w...

journal_title：Natural product research

authors： Li XQ,Dong QJ,Xu K,Yuan XL,Liu XM,Zhang P

更新日期：2020-10-04 00:00:00

abstract：:A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupe...

journal_title：Natural product research

authors： Chen F,Liu DL,Wang W,Lv XM,Li W,Shao LD,Wang WJ

更新日期：2020-10-01 00:00:00

abstract：:A new isopimarane-type diterpenoid, crolaevinoid A, along with four known analogues was isolated from the twigs and leaves of Croton laevigatus. The structures of the isolated compounds were established on the basis of NMR and MS spectroscopic analyses. The isolated compounds were examined the antibacterial activities...

journal_title：Natural product research

authors： Li MY,Han ZZ,Liu LF,Wu XZ,Huang WJ,Wang K,Yang F,Yuan CS

更新日期：2020-10-01 00:00:00

abstract：:Five new α-pyrones, xylariaopyrones E-I (1-5), along with three known analogues (6-8) were isolated from the cultivation broth of the endophytic fungus Xylariales sp. (HM-1). The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic methods and quantum E...

journal_title：Natural product research

authors： Yang WW,Lu LW,Zhang XQ,Bao SS,Cao F,Guo ZY,Deng ZS,Proksch P

更新日期：2020-09-30 00:00:00

abstract：:A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (-)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (-)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannine (5) and (-)-sophocarpine (6). Th...

journal_title：Natural product research

authors： Rong ZJ,Gao XX,Hu GS,Yan T,Jia JM,Wang AH

更新日期：2020-09-23 00:00:00

abstract：:Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3 - 17) were isolated from the stems of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cyclo...

journal_title：Natural product research

authors： Boonsombat J,Thongnest S,Kheawchaum S,Mahidol C,Ruchirawat S,Prawat H

更新日期：2020-09-22 00:00:00

abstract：:Eurya acuminata DC and Croton caudatus Gieseler are two ethno-medicinal plants used by Kuki community of North East India. From these plants, we have characterized fifteen phytochemicals (1-15) by extensive use of chromatographic and spectroscopic methods. They were also tested for in vitro cytotoxic effects against A...

journal_title：Natural product research

authors： Neipihoi,Narzary B,Saikia S,Saikia S,Tamuli KJ,Sahoo RK,Dutta D,Bordoloi M

更新日期：2020-09-16 00:00:00