Abstract:
:One new xanthone, chryxanthone C (1), together with four known analogues (2-5), were isolated from the cultures of Paecilamyces sp. TE-540, an endophytic fungus obtained from the leaves of Nicotiana tabacum L. The structure of 1 was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which were confirmed by Cu Kα X-ray crystallography. Compound 1 featured an unusual dihydropyran ring fused to an aromatic ring, rather than the commonly occurring prenyl moiety. The cytotoxicity of compounds 1-5 were evaluated against five human tumour cell lines and 4 exhibited moderate to strong cytotoxicities with IC50 values ranging from 5.6 to 14.2 µM.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Li XQ,Dong QJ,Xu K,Yuan XL,Liu XM,Zhang Pdoi
10.1080/14786419.2020.1828410subject
Has Abstractpub_date
2020-10-04 00:00:00pages
1-7eissn
1478-6419issn
1478-6427pub_type
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