New diterpene isopimara-7,15-dien-19-oic acid and its prolyl endopeptidase inhibitory activity.

abstract：:In Brazilian folk medicine, Protium heptaphyllum is used to treat inflammatory conditions and to hasten wound repair. This paper aims to investigate the chemical composition and the in vitro antibacterial effects of the essential oils (EOs) obtained from P. heptaphyllum leaves and ripe and unripe fruits against a repr...

journal_title：Natural product research

authors： Cabral RSC,Alves CCF,Batista HRF,Sousa WC,Abrahão IS,Crotti AEM,Santiago MB,Martins CHG,Miranda MLD

更新日期：2020-08-01 00:00:00

abstract：:The search for bioactive compounds against diseases is imperative and the richness of the Amazon provides a large source to be explored. Current therapies for the treatment of parasitic infections have severe side effects and low efficacy, which makes the development of an effective chemotherapy extremely important. I...

journal_title：Natural product research

authors： Fernandes NS,Desoti VC,Dias A,da Silva YC,de Azevedo Dos Santos AP,Passarini GM,Nakamura CV,da Veiga Junior VF

更新日期：2020-01-25 00:00:00

abstract：:Extracts obtained from Cyrtocarpa procera Kunth were evaluated to determine their toxicity on Artemia salina Leach. All the extracts showed a significant activity. Bioguided fractionation of these extracts led to the isolation of beta-sitosterol and the identification of 1,3-propyl-dipentadecanoate, 3-hydroxypropyl-9-...

journal_title：Natural product research

authors： Rodríguez-López V,Aguirre-Crespo F,Salazar L,Estrada-Soto S

更新日期：2006-01-01 00:00:00

abstract：:Two triterpenes (14S,17S,20S,24R)-25-hydroxy-14,17-cyclo-20,24-epoxy-malabarican-3-one (CEM, 1a) and (14S,17S,20S,24R)-20,24,25-trihydroxy-14,17-cyclomalabarican-3-one (CM, 2a) with a cyclobutane ring were reported, which have the same NMR data as ocotillone (1b) and gardaubryone C (2b), respectively. An incorrect str...

journal_title：Natural product research

authors： Duan ZK,Lv TM,Song GS,Wang YX,Lin B,Huang XX

更新日期：2020-06-11 00:00:00

abstract：:In our continuous search for cytotoxic compounds from the genus Zanthoxylum, chromatographic separation of the MeOH/CH2Cl2 (1:1) extract of Z. chalybeum yielded one new alkamide; 4-(isoprenyloxy)-3-methoxy-3,4-deoxymethylenedioxyfagaramide (1) and a known one; fagaramide (2). Similarly, from the MeOH/CH2Cl2 (1:1) extr...

journal_title：Natural product research

authors： Omosa LK,Mbogo GM,Korir E,Omole R,Seo EJ,Yenesew A,Heydenreich M,Midiwo JO,Efferth T

更新日期：2019-03-21 00:00:00

abstract：:This work reports the phytochemical profile and insecticidal properties of Perovskia artemisioides Boiss essential oil (PAEO) collected in Baluchestan, Iran. Totally, twenty-six substances were identified with 1,8-cineole (25.81%), geranyl acetate (13.00%) and linalool (10.21%) as dominant chemical metabolites by GC-M...

journal_title：Natural product research

authors： Sadeghi Z,Alizadeh Z,Khorrami F,Norouzi S,Moridi Farimani M

更新日期：2020-08-26 00:00:00

abstract：:Two new ditetrahydrofuran lignans, named sieverlignans A and B (1 and 2), together with six known ones (3-8), were isolated from the aerial parts of Artemisia sieversiana. Their structures were established on the basis of spectroscopic analysis including HRMS, NMR spectra and circular dichroism experiments. All the co...

journal_title：Natural product research

authors： Zhou XD,Xu XW,Shi LY,Chen SH,Zeng KW,Tu PF

更新日期：2020-01-13 00:00:00

abstract：:The antimicrobial activities of plant extracts have formed the basis of many alternative medicines. In this context, the genus Schinus L. (Anacardiaceae), exhibits many traditional uses in medicine. However, a few studies on the antimicrobial properties of Schinus areira essential oils were conducted. The essential oi...

journal_title：Natural product research

authors： Cutro AC,Castelli MV,López SN,Rosales MA,Hollmann A,Rodriguez SA

更新日期：2019-10-12 00:00:00

abstract：:A series of novel hydrocarbylidene nitrohydrazinecarboximidamides were designed and synthesized using an insecticidal natural product Galegine as a lead compound. The bioassay results show that the target compounds exhibited moderate to good insecticidal activities against Hyalopterus pruni Geoffroy at a concentration...

journal_title：Natural product research

authors： Wu Q,Zhao F,Zhu X,Zhou Z,Yang D,Xu Z,Li J,Qin Z

更新日期：2019-08-20 00:00:00

abstract：:4-Methoxybenzene-1-ONN-azoxyformamide (1), 4-methoxybenzene-1-azoformamide (2), 4-hydroxyben-zene-1-azoformamide (3) and 4-hydroxybenzene-1-ONN-azoxyformamide (4) were isolated from the fruiting bodies of Calvatia craniiformis and Lycoperdon hiemale, respectively. Compounds 1 and 4 showed radicle growth inhibitory act...

journal_title：Natural product research

authors： Kamo T,Kashiwabara M,Tanaka K,Ando S,Shibata H,Hirota M

更新日期：2006-05-10 00:00:00

abstract：:Pectins were isolated from bark, wood and pith of kenaf (Hibiscus cannabinus L.) variety Cuba108. Imidazole was used as extractant. The isolated pectins were studied by 13C nuclear magnetic resonance (13C-NMR) spectroscopy and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). From the spectroscopic...

journal_title：Natural product research

authors： Pappas CS,Tarantilis PA,Polissiou MG

更新日期：2003-06-01 00:00:00

abstract：:Alternanthera brasiliana is popularly known as 'penicillin' and used as an anti-inflammatory and for wound healing. The objective of this work was the phytochemical study of the species by analytical techniques such as LC-MS/MS and GC-MS. Twenty-seven compounds were identified, five by LC-MS and 22 by GC-MS analysis. ...

journal_title：Natural product research

authors： Alencar Filho JMT,Teixeira HAP,Sampaio PA,Pereira ECV,Amariz IAE,Rolim Neto PJ,Rolim LA,Araújo ECDC

更新日期：2020-02-01 00:00:00

abstract：:Novel derivatives of 4-oxo-3-methylcytisine with phenyl moiety bonded to starting molecule through various spacers were obtained from the 9-amino, -halo, -formyl and 11-halo precursors by reductive alkylation of amines, generation of amide, as well as thio- and carboxamide functions, cross-coupling reactions, aldehyde...

journal_title：Natural product research

authors： Tsypysheva I,Petrova P,Koval'skaya A,Lobov A,Sapozhnikova T,Makara N,Gabdrakhmanova S,Zarudii F

更新日期：2021-01-01 00:00:00

abstract：:Protein kinase C (PKC) plays a key role in neurotransmission in the central nervous system, and targeting PKC domain is considered as a strategy to modulate the anaesthetic effects. In this study, we described a synthetic pipeline to perform high-throughput virtual screening against a large library of 3D structural na...

journal_title：Natural product research

authors： Zhao J,Zhou C

更新日期：2015-01-01 00:00:00

abstract：:A new polycyclic polyprenylated acylphloroglucinol (1), nujiangefolin D, together with five known analogues (2-6), were isolated from the fruits of Garcinia nujiangensis. Compound 1 was screened by the LC-MS and LC-PDA. The structure of 1 was elucidated on the basis of extensive spectroscopic techniques including 1 D ...

journal_title：Natural product research

authors： Tang Z,Lu L,Zhou X,Shen J,Song W,Tang Y,Xia Z

更新日期：2020-09-01 00:00:00

abstract：:Fourteen wild strains of Staphylococcus aureus positive for gene sea were tested for enterotoxins production and the minimum inhibitory concentration of Leptospermum scoparium, Origanum majorana, Origanum vulgare, Satureja montana and Thymus vulgaris essential oils (EOs) were determined. After this trial, bacteria str...

journal_title：Natural product research

authors： Turchi B,Mancini S,Pistelli L,Najar B,Cerri D,Fratini F

更新日期：2018-03-01 00:00:00

abstract：:Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were ac...

journal_title：Natural product research

authors： Bruno de Sousa C,Lago JHG,Macridachis J,Oliveira M,Brito L,Vizetto-Duarte C,Florindo C,Hendrickx S,Maes L,Morais T,Uemi M,Neto L,Dionísio L,Cortes S,Barreira L,Custódio L,Alberício F,Campino L,Varela J

更新日期：2019-06-01 00:00:00

abstract：:Essential oil composition of the leaves of Viola odorata L. growing wild in Kashan, central Iran, was extracted by hydro distillation-solvent extraction method and analysed using GC-MS technique. The analysis revealed the presence of 25 identified compounds, representing 92.77% of the oil with butyl-2-ethylhexylphthal...

journal_title：Natural product research

authors： Akhbari M,Batooli H,Kashi FJ

更新日期：2012-01-01 00:00:00

abstract：:A new HPLC-DAD method was developed and validated for simultaneous determination of six main phenylethanoid glycosides (calceolarioside D, neocalceolarioside D, verbascoside, isoverbascoside, leucoseptoside A and martynoside) in the aerial parts of four Scutellaria L. taxa from flora of Turkey. All standard compounds ...

journal_title：Natural product research

authors： Bardakci H,Türköz Acar E,Kırmızıbekmez H

更新日期：2019-07-01 00:00:00

abstract：:Cynanchum acutum L. subsp. sibiricum (Willd.) Rech. f. was extracted with hexane, acetone, methanol and water individually. A sample was heated in water then extracted with ethyl acetate. Among the extracts, the ethyl acetate extract exhibited the most antiproliferative activity, so isolation of bioactive compounds wa...

journal_title：Natural product research

authors： Yildiz I,Sen O,Erenler R,Demirtas I,Behcet L

更新日期：2017-11-01 00:00:00

abstract：:A continuous phytochemical study on the seeds of Senna obtusifolia (Syn.: Cassia obtusifolia) led to the isolation of a new anthraquinone analogue, obtusifolin-2-O-β-D-(6'-O-α,β-unsaturated butyryl)-glucopyranoside (1) and a new eurotinone analogue, epi-9-dehydroxyeurotinone-β-D-glucopyranoside (2). Their structures w...

journal_title：Natural product research

authors： Pang X,Wang LM,Zhang YC,Kang LP,Yu HS,Fan GW,Han LF

更新日期：2019-12-01 00:00:00

abstract：:This study investigated the flavonoid constituents of a traditional Chinese medical plant Ziziphora clinopodioides Lam. by using ultra-performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry and screened the active components in regulating autophagy.Normal rat kidney (NRK) cells trans...

journal_title：Natural product research

authors： Zhang XM,An DQ,Guo LL,Yang NH,Zhang H

更新日期：2019-09-01 00:00:00

abstract：:Continued investigation of the marine alga Laurencia claviformis has led to the isolation of pacifenol, a halogenated sesquiterpene as the major metabolite. The microbial transformation of pacifenol is reported. It was cultivated with a marine strain of Penicillium brevicompactum yielding a new compound. The structure...

journal_title：Natural product research

authors： San-Martín A,Rovirosa J,Astudillo L,Sepúlveda B,Ruiz D,San-Martín C

更新日期：2008-12-01 00:00:00

abstract：:Fusarium graminearum Schw. is associated with diseases in seeds and seedlings, mainly in maize, and causes damage to crops and food production. We determined the chemical compositions of essential oils from Pogostemon cablin (Blanco) Benth and Baccharis dracunculifolia DC., and evaluated their antioxidant and antifung...

journal_title：Natural product research

authors： Luchesi LA,Paulus D,Busso C,Frata MT,Oliveira JB

更新日期：2020-08-06 00:00:00

abstract：:A new phenylpropanoid allopyranoside (1) and a new indolinone alkaloid (2) were isolated from the rhizomes of Actaea dahurica (syn. Cimicifuga dahurica). The structures of those two compounds were deduced as cimicifugaside F (1) and 3E,11E-(3-methyl-2-butenylidene acid)-2-indolinone-1-O-β-d-glucopyranoside (2) by deta...

journal_title：Natural product research

authors： Ma SJ,Li HB,Shao JR,Pang QQ,Li T,Yao XS,Yu Y

更新日期：2020-09-11 00:00:00

abstract：:New sesquiterpene glycoside, cyclodipeptide and piperidine derivative were isolated from Streptomyces sp. YIM 63342. On the basis of spectral data, their structures were determined as 3R, 5R, 6S, 7E, 9R-megastigman-7-en-3,5,6,9-tetrol-9-O-β-D-apiofuranosyl-(1→ 2)-β-D-glucopyranoside (1), cyclo (L-Pro-L-OMet) (2) and (...

journal_title：Natural product research

authors： Yang XQ,Yang YB,Zhou H,He GW,Zhao LX,Xu LH,Ding ZT

更新日期：2013-01-01 00:00:00

abstract：:Toxicity of the pesticide carbofuran (CF) can be alleviated by curcumin, if not for its poor bioavailability. Hence, we investigated the effect of a bioavailable curcumin-galactomannan complex (CGM) on CF-induced neurotoxicity in rats in comparison to that of unformulated standard curcumin (CS). The CF (5 mg/kg b.wt/d...

journal_title：Natural product research

authors： E R S,P P B,Nair SS,Maliakel B,Kuttan R,I M K

更新日期：2020-05-01 00:00:00

abstract：:Fructose feeding induces a rise in blood pressure in normal rats that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia, hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic administration of A-HRS (100 and 300 mg kg⁻¹; p.o.) isolated from Hibiscus rosa sinensis...

journal_title：Natural product research

authors： Mohan M,Khade B,Shinde A

更新日期：2012-01-01 00:00:00

abstract：:Topical sunscreens have been used for many years on exposed areas to protect the skin from the damaging effects of ultraviolets. If the sunscreens were essential, it is suggested that they have adverse effects. We chose to study ferulic acid ethyl ester (FAEE) as agent which could potentially be used in sunscreen prod...

journal_title：Natural product research

authors： Choquenet B,Couteau C,Paparis E,Coiffard LJ

更新日期：2008-01-01 00:00:00

abstract：:Cinobufagin (CBF) is an active ingredient isolated from Venenum Bufonis extracted and dried from the secretory glands of Bufo gargarizans Cantor. The purpose of the study was to investigate the effects and underlying mechanisms of CBF on human breast cancer MCF-7 cells in vitro. Our results showed that CBF exhibited o...

journal_title：Natural product research

authors： Zhu L,Chen Y,Wei C,Yang X,Cheng J,Yang Z,Chen C,Ji Z

更新日期：2018-02-01 00:00:00