Abstract:
:A series of novel hydrocarbylidene nitrohydrazinecarboximidamides were designed and synthesized using an insecticidal natural product Galegine as a lead compound. The bioassay results show that the target compounds exhibited moderate to good insecticidal activities against Hyalopterus pruni Geoffroy at a concentration of 200 mg/L, and most compounds show excellet insecticidal activities against Aphis gossypii Glover. In particular, compounds IIc-01, IIc-03, IIe-02 and IIf-01 show the equal activities to a commercial pesticide Imidacloprid with their LC50 values are 0.21 mg/L, 0.27 mg/L, 0.12 mg/L and 0.24 mg/L, respectively, and compounds IIc-02 and IIe-05 show 10 times insecticidal activities as much as Imidacloprid with their LC50 values both are 0.02 mg/L. Structure-activity relationship and 3D-QSAR analyses indicate that the introduction of fluorine atom is useful for increasing the insecticidal activity of target compounds.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Wu Q,Zhao F,Zhu X,Zhou Z,Yang D,Xu Z,Li J,Qin Zdoi
10.1080/14786419.2019.1655409subject
Has Abstractpub_date
2019-08-20 00:00:00pages
1-7eissn
1478-6419issn
1478-6427pub_type
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