Antimicrobial compounds from root, stem bark and seeds of Melia volkensii.

Abstract:

:Three compounds, toosendanin (1), kulactone (2) and scopoletin (3), were isolated from either the root bark and/or the stem bark of Melia volkensii. Their structures were determined on the basis of spectroscopic data generated and by comparison with data from the literature. 1 and 2, isolated for the first time from M. volkensii, exhibited significant (p < 0.05) activity against Escherichia coli with minimum inhibitory concentration of 12.5 μg/mL, close to that of neomycin (6.25 μg/mL). The compounds also exhibited high activity against Aspergillus niger (MIC 6.25 μg/mL compared to 2.5 μg/mL for clotrimazole). Dichloromethane and methanol seed, hexane stem bark and methanol root bark extracts exhibited activities towards Escherichia coli, Staphylococcus aureus, Aspergillus niger and Plasmodium falciparum, respectively. Antimicrobial activity of the plant towards A. niger, P. falciparum and S. aureus is reported for the first time in the current work.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Kamau RW,Juma BF,Baraza LD

doi

10.1080/14786419.2015.1101104

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1984-7

issue

17

eissn

1478-6419

issn

1478-6427

journal_volume

30

pub_type

杂志文章
  • Biotransformation of androst-4-ene-3,17-dione by three fungal species Fusarium solani BH1031, Aspergillus awamori MH18 and Mucor circinelloides W12.

    abstract::The microbial transformation of androst-4-ene-3,17-dione (4-AD; I) by three fungal species, involved Fusarium solani BH1031, Aspergillus awamori MH18 and Mucor circinelloides W12, has been studied. The latter two fungi were studied for the first time on biotransformation of 4-AD. The main product obtained by Fusarium ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1636238

    authors: An X,Gao P,Zhao S,Zhu L,You X,Li C,Zhang Q,Shan L

    更新日期:2021-02-01 00:00:00

  • Blood orange (Citrus sinensis) as a rich source of nutraceuticals: investigation of bioactive compounds in different parts of the fruit by HPLC-PDA/MS.

    abstract::This study is part of a wider investigation aimed to sustain the economical value of the by-products generated by the Citrus industry. In particular, the protected geographic indication (PGI) red orange of sicily (known as blood orange) has been analysed by HPLC and by the enzymatic AOAC method. All the by-products co...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1696329

    authors: Russo M,Bonaccorsi IL,Arigò A,Cacciola F,De Gara L,Dugo P,Mondello L

    更新日期:2019-11-29 00:00:00

  • Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana.

    abstract::α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.986729

    authors: Morelli CF,Biagiotti M,Pappalardo VM,Rabuffetti M,Speranza G

    更新日期:2015-01-01 00:00:00

  • Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09.

    abstract::An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1295240

    authors: Wang F,Fu SN,Bao YX,Yang Y,Shen HF,Lin BR,Zhou GX

    更新日期:2017-08-01 00:00:00

  • Evaluation of seasonal chemical composition, antibacterial, antioxidant and anticholinesterase activity of essential oil from Eugenia brasiliensis Lam.

    abstract::This study describes the seasonal composition and the antibacterial, antioxidant and anticholinesterase activity of the essential oil from Eugenia brasiliensis leaves. Analysis by using GC allowed the identification of 40 compounds. It was observed that the monoterpenes varied more (42%) than the sesquiterpenes (14%),...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.958736

    authors: Siebert DA,Tenfen A,Yamanaka CN,de Cordova CM,Scharf DR,Simionatto EL,Alberton MD

    更新日期:2015-02-01 00:00:00

  • Bioactive terpenoids from the Red Sea soft coral Sinularia polydactyla.

    abstract::Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3β,25-diol (2), in addition to a cembranoid diterpene, durumolide C ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2013.805333

    authors: Aboutabl el-SA,Azzam SM,Michel CG,Selim NM,Hegazy MF,Ali AH,Hussein AA

    更新日期:2013-01-01 00:00:00

  • Topical anti-inflammatory constituents of lipophilic leaf fractions of Alchornea floribunda and Alchornea cordifolia.

    abstract::The leaves of Alchornea floribunda and Alchornea cordifolia are used traditionally as topical anti-inflammatory agents. In this study, two highly lipophilic fractions AFLF and ACLF isolated from A. floribunda and A. cordifolia leaves respectively were investigated for topical anti-inflammatory effects using xylene-ind...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.512272

    authors: Okoye FB,Osadebe PO,Nworu CS,Okoye NN,Omeje EO,Esimone CO

    更新日期:2011-12-01 00:00:00

  • Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum.

    abstract::Illicium lanceolatum is a popular aromatic and medicinal plant in China. Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS. The essential oil was dominated by phenylpropenes. The major components were myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%)...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.603318

    authors: Liang J,Huang B,Wang G

    更新日期:2012-01-01 00:00:00

  • Chemical composition and medicinal significance of Fagonia cretica: a review.

    abstract::Members of the family Zygophyllaceae are distributed in arid areas of the world and are traditionally used against various health insults ranging from skin lesions to lethal cancer. Fagonia cretica Linn. is a plant having novel compounds responsive in diseases that are still considered as incurable or are curable with...

    journal_title:Natural product research

    pub_type: 杂志文章,评审

    doi:10.1080/14786419.2015.1036268

    authors: Qureshi H,Asif S,Ahmed H,Al-Kahtani HA,Hayat K

    更新日期:2016-01-01 00:00:00

  • Studies on the chemical constituents of Phyllanthus emblica.

    abstract::Phytochemical investigations on Phyllanthus emblica have resulted in the isolation of the two new flavonoids, kaempferol-3-O-alpha-L-(6''-methyl)-rhamnopyranoside (1) and kaempferol-3-O-alpha-L-(6''-ethyl)-rhamnopyranoside (2). Their structures were determined on the basis of extensive spectroscopic studies including ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601124664

    authors: Habib-ur-Rehman,Yasin KA,Choudhary MA,Khaliq N,Atta-ur-Rahman,Choudhary MI,Malik S

    更新日期:2007-07-20 00:00:00

  • Essential oil composition of aerial parts of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson.

    abstract::The essential oil of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson syn. Apium leptophyllum (Pers.) F. Muell. Ex Benth., family Apiaceae (Umbellifereae), was analysed by GC and GC-MS. The essential oil showed the presence of thymohydroquinone dimethyl ether (50.7%), thymol methyl ether (11.2%), γ-t...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.487190

    authors: Pande C,Tewari G,Singh C,Singh S

    更新日期:2011-03-01 00:00:00

  • Antioxidant activity and two new flavonoids from Washingtonia filifera.

    abstract::Two new flavonoids, 8-hydroxyisoscoparin (1) and luteolin 7-O-glucoside 4''-sulfate (2), along with eight known flavonoids, including luteolin 7-O-glucoside 2''-sulfate, were isolated and identified from Washingtonia filifera. All compounds were characterized by (1)H-NMR, (13)C-NMR, CI-MS, FABMS and UV. The antioxidan...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/1478641500059276

    authors: El-Sayed NH,Ammar NM,Al-Okbi SY,El-Kassem LT,Mabry TJ

    更新日期:2006-01-01 00:00:00

  • Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors.

    abstract::Acetylcholinesterase (AChE) inhibitors have been used for the symptomatic treatment of Alzheimer's disease. Eleven whole plants from Panama belonging to the Lycopodiaceae family have been screened for their anticholinesterase inhibitory and antioxidant activities by a thin-layer chromatography (TLC) bioautography meth...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2012.701217

    authors: Calderón AI,Simithy-Williams J,Sanchez R,Espinosa A,Valdespino I,Gupta MP

    更新日期:2013-03-01 00:00:00

  • A new furofuran lignan from Piper terminaliflorum Tseng.

    abstract::The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2-4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undec...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1350671

    authors: Liu T,Liang Q,Zhang XM,Huang SY,Xu WH

    更新日期:2018-02-01 00:00:00

  • Prospective study of a Bothrops jararacussu venom batch (Bj2015) - phospholipase A2 activity, immunogenicity, neurotoxicity, and myotoxicity parameters.

    abstract::Bothrops jararacussu venom's (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A2 (PLA2) activity, immunogenicity, neurotoxicity, and myotoxicity. In silico models were applied to evaluate losses using decay model and recoveries by predictive trend analysis. Mice were immunized with Bj2015...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1446010

    authors: Oliveira ICF,Mora AD,Neto JB,de Oliveira ÁL,Harder C,Hanai-Yoshida VM,Cogo JC,Floriano RS,Bonventi Junior W,Oliveira SJ,Oshima-Franco Y

    更新日期:2019-08-01 00:00:00

  • Characterization of foxing stains in early twentieth century photographic and paper materials.

    abstract::The subject of this present work is a group of nine historical pictures shot in Palermo by the Sicilian photographer E. Interguglielmi in 1912. They are nine matte-collodion prints mounted on the original cardboard supports and all of them show foxing stains affecting the paper surface. In order to characterise the ch...

    journal_title:Natural product research

    pub_type: 历史文章,杂志文章

    doi:10.1080/14786419.2016.1180600

    authors: Modica A,Bruno M,Di Bella M,Alberghina MF,Brai M,Fontana D,Tranchina L

    更新日期:2019-04-01 00:00:00

  • Herbicidal effects of extracts and residue incorporation of Datura metel against parthenium weed.

    abstract::The present study was designed to evaluate the herbicidal activity of Datura metel against the noxious weed parthenium (Parthenium hysterophorus L.). In a laboratory bioassay, the effect of aqueous, methanol and n-hexane shoot and root extracts of 5, 10, 15 and 20% w/v (on a fresh weight basis) concentration of D. met...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410903075440

    authors: Javaid A,Shafique S,Shafique S

    更新日期:2010-09-01 00:00:00

  • Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects.

    abstract::A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.589386

    authors: Lekshmi PC,Arimboor R,Raghu KG,Menon AN

    更新日期:2012-01-01 00:00:00

  • The antioxidant power of horseradish, Armoracia rusticana, underlies antimicrobial and antiradical effects, exerted in vitro.

    abstract::Armoracia rusticana (AR) was tested for antimicrobial and antioxidants power. The compound demonstrated to inhibit fish pathogens such as Vibrio anguillarum, V. harvey, V. alginolyticus, Aeromonas hydrophila, A. salmonicida, Photobacterium damselae subspecie piscicida, Tenacibaculum marinum and Pseudomonas anguillisep...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1517121

    authors: Manuguerra S,Caccamo L,Mancuso M,Arena R,Rappazzo AC,Genovese L,Santulli A,Messina CM,Maricchiolo G

    更新日期:2020-06-01 00:00:00

  • A new sesquiterpenoid from Scaphium macropodum (Miq.) Beumee.

    abstract::A new sesquiterpenoid, malayscaphiol (1), and three known compounds, lupeol (2), lupenone (3) and stigmasterol (4), were isolated from the methanolic extract of the stem bark of Scaphium macropodum. The structures of the isolated compounds were determined using several spectroscopic methods, including UV-vis, FT-IR, 1...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.886211

    authors: Al Muqarrabun LM,Ahmat N,Aris SR,Shamsulrijal N,Baharum SN,Ahmad R,Rosandy AR,Suratman MN,Takayama H

    更新日期:2014-01-01 00:00:00

  • In vitro antioxidant and antiproliferative activities of nine Salvia species.

    abstract::Supported by a growing increase of scientific research attesting the health properties of salvia species, we have decided to investigate nine Salvia namely Salvia sclarea, Salvia atropatana, Salvia sahendica, Salvia hydrangea, Salvia xanthocheila, Salvia macrosiphon, Salvia glutinosa, Salvia chloroleuca and Salvia cer...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.939086

    authors: Loizzo MR,Abouali M,Salehi P,Sonboli A,Kanani M,Menichini F,Tundis R

    更新日期:2014-01-01 00:00:00

  • A new xanthone from the bark of Calophyllum thorelii.

    abstract::A new xanthone, calothorexanthone, together with five known compounds, garbogiol, 1,4,8-trihydroxyxanthone, δ-tocotrienol, 1,7-dihydroxyxanthone and globuxanthone, was isolated from a petroleum ether extract of the bark of Calophyllum thorelii. Their structures were established on the basis of spectroscopic methods, m...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2012.682992

    authors: Nguyen LT,Nguyen DM,Nguyen LH

    更新日期:2013-01-01 00:00:00

  • Design, synthesis and insecticidal activity of novel semicarbazones and thiosemicarbazones derived from chalcone.

    abstract::Thirty semicarbazone and thiosemicarbazone derivatives (2a-w and 4a-g) from chalcones containing furan and thiophene ring were designed and synthesized. They were characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure of compound 2r was characterized by single crystal X-ray diffraction. It crystallizes i...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1739679

    authors: Cheng W,Xiao T,Qian W,Lu T,Zhang T,Tang X

    更新日期:2020-03-16 00:00:00

  • Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin.

    abstract::ABTRACT This study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds e1-e25 have been characterized by 1H NMR,...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1806268

    authors: Jin Y,Ding YH,Dong JJ,Wei Y,Hao SH,Feng BC

    更新日期:2020-08-13 00:00:00

  • Phytochemical, cytotoxic and chemotaxonomic study on Ajuga forrestii Diels (Labiatae).

    abstract::A phytochemical investigation of Ajuga forrestii Diels led to the isolation of 14 compounds, including eight neo-clerodane diterpenes (1-8), two phytoecdysteroids (9, 11), one stigmastane sterol (10) and three iridoid glycosides (12-14). The structures of these compounds were identified by spectroscopic methods and a ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1371161

    authors: Chen T,Diao QY,Yu HZ,Jiao CL,Ruan J

    更新日期:2018-04-01 00:00:00

  • A new dolabellane diterpenoid from the Hainan soft coral Spongodes sp.

    abstract::A new dolabellane diterpenoid (1R*,3E,7E,9S*,11S*,12Z)-9-hydroxydolabella-3,7,12-triene (1), along with seven known compounds (2-8), has been isolated from the Hainan soft coral Spongodes sp. Their structures were elucidated on the basis of spectroscopic analysis and compared with those previously reported in literatu...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601130034

    authors: Yan XH,Jia R,Shen X,Guo YW

    更新日期:2007-08-01 00:00:00

  • Chemical constituents and antibacterial activity of Melastoma malabathricum L.

    abstract::The aqueous methanolic extracts of Melastoma malabathricum L. exhibited antibacterial activity when assayed against seven microorganisms by the agar diffusion method. Solvent fractionation afforded active chloroform and ethyl acetate fractions from the leaves and the flowers, respectively. A phytochemical study result...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.538395

    authors: Wong KC,Hag Ali DM,Boey PL

    更新日期:2012-01-01 00:00:00

  • Cytotoxic flavonoids from two Lonchocarpus species.

    abstract::A new isoflavone, 4'-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2'-dimethoxy-3',4...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1462179

    authors: Adem FA,Kuete V,Mbaveng AT,Heydenreich M,Koch A,Ndakala A,Irungu B,Yenesew A,Efferth T

    更新日期:2019-09-01 00:00:00

  • A new anthraquinone from Galium verum L.

    abstract::A new anthraquinone (4) and three known anthraquinones (1-3) were isolated from Galium verum L. Their structures were identified as 1,3-dihydroxy-2-methylanthraquinone (1), physcion (2), 2-hydroxy-1,3-dimethoxyanthraquinone (3), 2,5-dihydroxy-1,3-dimethoxyanthraquinone (4) by means of chemical and spectroscopic analys...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410600921532

    authors: Zhao CC,Shao JH,Li X,Xu J,Wang JH

    更新日期:2006-09-01 00:00:00

  • A kaempferol triglycoside from Tephrosia preussii Taub. (Fabaceae).

    abstract::A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitostero...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1315720

    authors: Mba Nguekeu YM,Awouafack MD,Tane P,Nguedia Lando MR,Kodama T,Morita H

    更新日期:2017-11-01 00:00:00