Abstract:
:One new iridoid glycoside, 6',10-di-O-(4-hydroxybenzoyl) aucubin (1), together with ten known compounds, including five diterpenoids (2-6), two triterpene glucosides (7-8) and three methoxylated flavonoids (9-11) were isolated from the fruits of Vitex rotundifolia. Compounds (3, 4, 7, and 8) were reported for the first time from this plant. Their structures were elucidated by spectral analysis and by comparison with literature data. Furthermore, some of the isolated compounds were evaluated for their cytotoxicities against A549 and HepG-2 cell lines using MTT assay, and only compounds 9 and 10 exhibited potent cytotoxic activity with IC50 values of 13 ± 4 and 35 ± 10 μM against HepG-2 cell lines.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Zhao YY,Guo L,Cao LJ,Zhang J,Yin ZQdoi
10.1080/14786419.2017.1314284subject
Has Abstractpub_date
2017-11-01 00:00:00pages
2491-2496issue
21eissn
1478-6419issn
1478-6427journal_volume
31pub_type
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