A new iridoid glycoside from the fruits of Vitex rotundifolia.

Abstract:

:One new iridoid glycoside, 6',10-di-O-(4-hydroxybenzoyl) aucubin (1), together with ten known compounds, including five diterpenoids (2-6), two triterpene glucosides (7-8) and three methoxylated flavonoids (9-11) were isolated from the fruits of Vitex rotundifolia. Compounds (3, 4, 7, and 8) were reported for the first time from this plant. Their structures were elucidated by spectral analysis and by comparison with literature data. Furthermore, some of the isolated compounds were evaluated for their cytotoxicities against A549 and HepG-2 cell lines using MTT assay, and only compounds 9 and 10 exhibited potent cytotoxic activity with IC50 values of 13 ± 4 and 35 ± 10 μM against HepG-2 cell lines.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Zhao YY,Guo L,Cao LJ,Zhang J,Yin ZQ

doi

10.1080/14786419.2017.1314284

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

2491-2496

issue

21

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

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