Abstract:
:A new malyngamide (1) was isolated along with seven known compounds (2-8) from the marine cyanobacterium Moorea producens collected in Hawaii. Compound 1 represented the first reported malyngamide with a hydroxy moiety at C-7 of the characteristic fatty acid portion of the compound. Compound 1 showed cytotoxicity against L1210 cell line at an IC50 value of 2.9 mM and lethal toxicity against the shrimp Palaemon paucidens at a LD100 value of 33.3 mg/kg. The bioactivity of compound 1 was approximately 10-100 times weaker than those of isomalyngamides A and B (3, 4). These results indicated that the methoxy group at C-7 of the fatty acid section confers a degree of bioactivity in malyngamides.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Jiang W,Zhou W,Othman R,Uchida H,Watanabe R,Suzuki T,Sakamoto B,Nagai Hdoi
10.1080/14786419.2017.1338282subject
Has Abstractpub_date
2018-01-01 00:00:00pages
97-104issue
1eissn
1478-6419issn
1478-6427journal_volume
32pub_type
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