Abstract:
:Nine resorcinol derivatives including two new ones, 5-[(8Z,11Z,14Z)-nonadeca-8,11,14-trienyl] resorcinol (1) and 5-[(8Z,11Z,14E)-heptadeca-8,11,14-trienyl] resorcinol (2), were isolated from the leaves of Syzygium samarangense. The new structures were elucidated by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Among them, compounds 3, 4, 6 and 7 exhibited significant α-glucosidase inhibitory activities with IC50 of 3.16, 3.16, 2.34 and 0.99 µM, respectively. This finding provides evidence that resorcinol derivatives with long aliphatic chain function as new promising antidiabetic alternatives.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Hu YK,Wang L,Wang JH,Li MJ,Li F,Yang J,Zhao Ydoi
10.1080/14786419.2020.1805606subject
Has Abstractpub_date
2020-08-13 00:00:00pages
1-6eissn
1478-6419issn
1478-6427pub_type
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