Urinary metabolites of cinobufagin in rats and their antiproliferative activities.

abstract：:Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. In the present study, the endophytic fungus Aspergillus calidoustus was isolated from the medicinal plant Acanthospermum australe (Asterac...

journal_title：Natural product research

authors： de Carvalho CR,Vieira Mde L,Cantrell CL,Wedge DE,Alves TM,Zani CL,Pimenta RS,Sales Junior PA,Murta SM,Romanha AJ,Rosa CA,Rosa LH

更新日期：2016-01-01 00:00:00

abstract：:This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activit...

journal_title：Natural product research

authors： Stojanović G,Zlatanović I,Zrnzević I,Stanković M,Stankov Jovanović V,Zlatković B

更新日期：2018-11-01 00:00:00

abstract：:Two new ent-atisanes ent-1β,3β,16β,17-tetrahydroxyatisane (1), ent-1β,3α,16β,17-tetrahydroxyatisane (2) together with 11 known diterpenes were isolated from the anti-tumour activity fraction of Euphorbia fischeriana Steud. The compounds were identified by detailed spectroscopic analysis, including extensive 2D-NMR exp...

journal_title：Natural product research

authors： Wang M,Wang Q,Wei Q,Li J,Guo C,Yang B,Kuang H

更新日期：2016-01-01 00:00:00

abstract：:A short total synthesis of natural isocarbostyril ruprechstyril (3-n-pentyl-6-methoxy-8-hydroxy-1(2H)-isoquinolinone) isolated from Ruprechtia tangarana is reported. 6,8-Dimethoxy-3-pentylisocoumarin obtained by condensation of 3,5-dimethoxyhomophthalic anhydride with hexanoyl chloride was smoothly converted to O-meth...

journal_title：Natural product research

authors： Saeed A

更新日期：2013-01-01 00:00:00

abstract：:Six new compounds, including three terpenoids (1-3) and three lignans (4-6), were isolated from the 95% EtOH extract of the twigs of Tripterygium hypoglaucum. Their structures were determined on the basis of extensive spectroscopic analysis. 9'-O-benzoyl-lariciresinol (4) showed weak cytotoxicity against HepG2/Adr cel...

journal_title：Natural product research

authors： Zheng H,Wang L,Yang T,Liu D,Li HM,Chen XQ,Li RT

更新日期：2020-07-01 00:00:00

abstract：:The fatty acid compositions of Nepeta viscida, N. cilicica, N. crinita, N. nuda ssp. glandulifera and N. aristata were analyzed by GC/MS. The main free fatty acids were found as linolenic acid (49.8-58.5%), linoleic acid (10.9-23.5%), oleic acid (11.5-19.2%), palmitic acid (5.2-6.8%) and stearic acid (2.0-3.7%) and, t...

journal_title：Natural product research

authors： Kiliç T,Dirmenci T,Gören AC

更新日期：2007-05-01 00:00:00

abstract：:A new indole diterpene, named penicindopene A (1), together with seven known compounds (2 - 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for...

journal_title：Natural product research

authors： Liu L,Xu W,Li S,Chen M,Cheng Y,Yuan W,Cheng Z,Li Q

更新日期：2019-10-01 00:00:00

abstract：:Dunaliine A (1), a new amino diketone, has been isolated from the leaves of Desmos dunalii together with four known dihydrochalcones: 2',4-dihydroxy-4',6'-dimethoxy-3',5'-dimethyldihydrochalcone (2), 2',4-dihydroxy-4',6'-dimethoxydihydrochalcone (3), 2',4-dihydroxy-4',5',6'-trimethoxydihydrochalcone (4) and 2',4-dihyd...

journal_title：Natural product research

authors： Awang K,Abdullah Z,Mukhtar MR,Litaudon M,Jaafar FM,Hadi AH,Thomas NF

更新日期：2009-01-01 00:00:00

abstract：:In this study the crude ethyl acetate extracts and fractions from red algae Gracilaria edulis were studied against fish pathogens. G. edulis was extracted with ethyl acetate, fractionated in silica gel coloum chromatography and gradient hexane-ethyl acetate. The extract and fractions were subjected for bioassay guided...

journal_title：Natural product research

authors： Kasanah N,Amelia W,Mukminin A,Triyanto,Isnansetyo A

更新日期：2019-11-01 00:00:00

abstract：:The CDC25 phosphatases regulate the cell division cycle by controlling the activity of cyclin-dependent kinases. While screening for inhibitors of phosphatases among natural products we repeatedly found that some polyprenyl-hydroquinones and polyprenyl-furans (furanoterpenoids) (furospongins, furospinosulins) were pot...

journal_title：Natural product research

authors： Erdogan-Orhan I,Sener B,de Rosa S,Perez-Baz J,Lozach O,Leost M,Rakhilin S,Meijer L

更新日期：2004-02-01 00:00:00

abstract：:Two new ergosterol derivatives namely, chlamydosterols A [(22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol 6-decanoate] (1) and B [5α,6β,25-trihydroxy-(22E,24R)-ergosta-7,22-dien-3-one] (5) and three known ergosterols: ergosta-7,22-dien-3β-ol (2), ergosta-5,7,22-triene-3β-ol (3), and ergosta-7,22-diene-3β,5α,6β-triol (4) w...

journal_title：Natural product research

authors： Al-Rabia MW,Mohamed GA,Ibrahim SRM,Asfour HZ

更新日期：2020-05-06 00:00:00

abstract：:The chemical composition of the essential oil of Kurzamra pulchella (Lamiaceae) was determined. Twelve compounds were identified, with isomenthone (60.6%) and pulegone (37.1%) predominating. Chemotaxonomical considerations were discussed. ...

journal_title：Natural product research

authors： Echeverría J,Niemeyer HM

更新日期：2017-01-01 00:00:00

abstract：:Oxygen radical absorbance capacity (ORAC) is a widely used hydrogen atom transfer-based method which measures the antioxidant capacity of natural products. ORAC values of oleaster (Elaeagnus angustifolia L.), which was extracted with ethanol/acetone (7:3, v/v), ethanol/water (1:1, v/v) and methanol/water (1:1, v/v) in...

journal_title：Natural product research

authors： Yalcin G,Sogut O

更新日期：2014-01-01 00:00:00

abstract：:A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity toward HCT-116 cel...

journal_title：Natural product research

authors： Liu LF,Zhang H,Qi H,Wang XM,Wang JD,Tan GS

更新日期：2017-05-01 00:00:00

abstract：:Members of the family Zygophyllaceae are distributed in arid areas of the world and are traditionally used against various health insults ranging from skin lesions to lethal cancer. Fagonia cretica Linn. is a plant having novel compounds responsive in diseases that are still considered as incurable or are curable with...

journal_title：Natural product research

authors： Qureshi H,Asif S,Ahmed H,Al-Kahtani HA,Hayat K

更新日期：2016-01-01 00:00:00

abstract：:A new hexadienamide derivative named sarmentosamide (1) was identified from the culture of Streptomyces sp. SBI108 isolated from Thai soil under an herb. The structure was elucidated on the basis of spectroscopic data, and the absolute configuration was determined by chemical degradation. ...

journal_title：Natural product research

authors： Kitani S,Tomio A,Srichaisupakit A,Daduang R,Intra B,Panbangred W,Oku N,Igarashi Y,Nihira T

更新日期：2013-01-01 00:00:00

abstract：:Camptothecin (CPT), the derivatives of which are used clinically for the treatment of metastatic colon cancer, is isolated from intact plants that can be subjected to environmental fluctuations. In vitro cultures may be an alternate and continuous source for year-round production of CPT. Since CPT production by undiff...

journal_title：Natural product research

authors： Kamble S,Gopalakrishnan R,Eapen S

更新日期：2011-10-01 00:00:00

abstract：:The main purpose of this study was the characterisation of 'Serra da Lousã' heather honey by using novel statistical methodology, relevant principal component analysis, in order to assess the correlations between production year, locality and composition. Herein, we also report its chemical composition in terms of sug...

journal_title：Natural product research

authors： Martins RC,Lopes VV,Valentão P,Carvalho JC,Isabel P,Amaral MT,Batista MT,Andrade PB,Silva BM

更新日期：2008-01-01 00:00:00

abstract：:From analysis by gas chromatography/mass spectrometry (GC/MS), the presence of either 2,4,5-tribromo-1H-imidazole (1) or 3,4,5-tribromo-1H-pyrazole (2) was tentatively identified in lipophilic extracts from the egg masses of three muricid molluscs. Synthesis of these compounds, followed by comparison of the GC retenti...

journal_title：Natural product research

authors： Benkendorff K,Pillai R,Bremner JB

更新日期：2004-10-01 00:00:00

abstract：:Two new eremophilenolides, ligushicins A (1) and B (2), and two known compounds including β-sitosterol and ursolic acid were isolated from Ligulariopsis shichuana. The structures of new compounds were established on the basis of 1D and 2D NMR data and HRESIMS data interpretation. The absolute configuration of new comp...

journal_title：Natural product research

authors： Wu H,Liu T,Lian Y,Wang W

更新日期：2019-05-01 00:00:00

abstract：:One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound showed an outstanding ...

journal_title：Natural product research

authors： Wang YQ,Li HX,Liu XC,Zhao JS,Liu RQ,Huai WY,Ding WJ,Zhang TE,Deng Y

更新日期：2019-12-01 00:00:00

abstract：:A new sesquiterpeniod, 6alpha, 7alpha, 10alpha-trihydroxyisoducane (1), together with two known sesquiterpenoids, oplodiol (2) and oplopanone (3), were isolated from the chloroform extract of the rhizomes of Homalomena occulta. Their structures were elucidated by 1D and 2D NMR spectral interpretation. ...

journal_title：Natural product research

authors： Hu YM,Yang ZL,Wang H,Ye WC

更新日期：2009-01-01 00:00:00

abstract：:Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography (GC-FID) was explored to determine the fingerprinting characteristic of Zingiber zerumbet L. volatiles to differentiate between different ginger species. The effect of different fibers [polydimethylsiloxane (PDMS, 7 μm), polyacrylate (PA, ...

journal_title：Natural product research

authors： Bhavya ML,Ravi R,Madhava Naidu M

更新日期：2019-07-22 00:00:00

abstract：:A new oleanane triterpenoid (2) was isolated from the roots of Rubia philippinensis. The structure of 2 was determined by analysis of HRMS and NMR data and identified as a rubiprasin analogue, 16β-hydroxyrubiprasin B. Four related known compounds were also encountered which include rubiprasin B (1), maslinic acid (3),...

journal_title：Natural product research

authors： Quan KT,Min BG,Hwang IH,Choi YJ,Kim SK,Na M

更新日期：2019-07-25 00:00:00

abstract：:This study is part of a wider investigation aimed to sustain the economical value of the by-products generated by the Citrus industry. In particular, the protected geographic indication (PGI) red orange of sicily (known as blood orange) has been analysed by HPLC and by the enzymatic AOAC method. All the by-products co...

journal_title：Natural product research

authors： Russo M,Bonaccorsi IL,Arigò A,Cacciola F,De Gara L,Dugo P,Mondello L

更新日期：2019-11-29 00:00:00

abstract：:Excessive accumulation of iron in the body can lead to organ injury. Some flavonoids which possess high affinity to iron can be used as iron chelators for curing iron overload diseases such as haemochromatosis. In this article, the effects of baicalin and quercetin on different mouse tissues (liver, kidney and heart) ...

journal_title：Natural product research

authors： Zhang Y,Gao Z,Liu J,Xu Z

更新日期：2011-07-01 00:00:00

abstract：:Two new ent-atisanediterpenoids, ent-atisane-16β, 17-isopropylidenedioxy-19-ol-3-one (1) and ent-atisane-16β, 17-isopropylidenedioxy-11β, 18-dihydroxyl-3-one (2) were isolated from the whole plants of Euphorbia wallichii. Their structures were elucidated on the basis of extensive spectroscopic analyses. ...

journal_title：Natural product research

authors： Kuang Y,Fu SY,Wang F,Ren FC,Yang DF,Yang SX,Gao Y

更新日期：2017-04-01 00:00:00

abstract：:α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, ...

journal_title：Natural product research

authors： Morelli CF,Biagiotti M,Pappalardo VM,Rabuffetti M,Speranza G

更新日期：2015-01-01 00:00:00

abstract：:Pigeon Pea is a well-received traditional nutritious and medicinal plant in India since ancient times. The plant is identified for its impressive pharmacological activities like antimicrobial, anti-inflammatory, antitubercular, antioxidant, neuroprotective, antihypertensive, antihyperglycemic and anticancer properties...

journal_title：Natural product research

authors： Dinore JM,Farooqui M

更新日期：2020-11-23 00:00:00

abstract：:Essential oil from Cochlospermum regium (Schrank) Pilg. leaves (CR-EO) has been extracted by hydrodistillation; we analysed the CR-EO by gas chromatography coupled with mass spectrometry. We also conducted histochemical analysis on cross-sections of the central vein of young and adult leaves. A total of 32 compounds w...

journal_title：Natural product research

authors： Inácio MC,Paz TA,Bertoni BW,Vieira MA,Marques MO,Pereira AM

更新日期：2014-01-01 00:00:00