Abstract:
:This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activity. Additionally, antioxidant (estimated via DPPH, ABTS, TRP, CUPRAC and TPC assays) and antibacterial activity against two Gram-positive and three Gram-negative bacteria were also determined. The HPLC-UV analysis revealed the presence of depsidones, 3-hydroxyphysodic, 4-O-methyl physodic acid, physodic and physodalic acid together with two depsides, atranorin and chloroatranorin. GC-FID and GC-MS analyses enabled the identification of atranol, chloroatranol, atraric acid, olivetol, olivetonide and 3-hydroxyolivetonide as the main components. The results of present study show that H. tubulosa acetone extract is a promising candidate for in vivo experiments considering antioxidant activity.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Stojanović G,Zlatanović I,Zrnzević I,Stanković M,Stankov Jovanović V,Zlatković Bdoi
10.1080/14786419.2017.1375926subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2735-2739issue
22eissn
1478-6419issn
1478-6427journal_volume
32pub_type
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