A new benzophenone glycoside from the leaves of Mitracarpus villosus.

Abstract:

:A new benzophenone glycoside, mitraphenone A (1), together with three known compounds (2-4) were isolated from the leaves of the traditionally used medicinal plant Mitracarpus villosus (Rubiaceae) collected in Nigeria. A combination of one- and two-dimensional NMR spectroscopic and mass spectrometric measurements were carried out to identify the structure of 1. All isolated compounds (1-4) were screened for their antibacterial activity against several Gram-positive and Gram-negative bacteria. Compound 1 exhibited moderate activity against Enterococcus faecium (strains ATCC 35667 and ATCC 700221) and Staphylococcus aureus ATCC 25923 with MIC values ranging from 25 to 50 μM.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Ngwoke KG,Orame N,Liu S,Okoye FBC,Daletos G,Proksch P

doi

10.1080/14786419.2017.1306701

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

2354-2360

issue

20

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

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