Antimicrobial pentacyclic triterpenes and glycosides from the stem bark of Cussonia bancoensis.

Abstract:

:The stem bark of Cussonia bancoensis is used traditionally for the treatment of different types of infection and pain. A bioassay guided fractionation of the methanol stem bark extract led to the isolation of five pentacyclic triterpenes and glycosides identified based on spectroscopic data as 23-hydroxyursolic acid (CB1), hederagenin (CB2), 3-O-α-L-arabinopyranosyl-echinocystic acid (CB3), 3-O-α-L-arabinopyranosyl- oleanolic acid (CB4) and 3-O-α-L-arabinopyranosyl-ursolic acid (CB5). CB2 - CB5 are being reported for the first time from this species. The compounds were evaluated for antimicrobial activity against ten microorganisms using the HT-SPOTi method. CB3 demonstrated remarkable antimicrobial activity against S. aureus, S. pyogens, E. faecalis, S. typhi and C. albicans at MICs between 3.12 and 12.5 µg/mL. Among the studied compounds, it was observed that hydroxylation of position C-16 of the oleanane skeleton may enhance antimicrobial activity. This study gives insight into the anti-infective constituents of the stem bark of C. bancoensis and justifies its use in ethnomedicine.[Formula: see text].

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Mireku EA,Mensah AY,Amponsah IK,Danquah CA,Anokwah D,Kwesi Baah M

doi

10.1080/14786419.2018.1503262

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

859-862

issue

6

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

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