Abstract:
:Euphorbia hirta (L.) plant is traditionally used in Malaysia for the treatment of gastrointestinal, bronchial and respiratory ailments caused by nosocomial infectious agents. Bioactivity-guided fractionation of the methanol extract of the aerial parts of E. hirta and analysis using high-performance liquid chromatography have led to the isolation of two antibacterial compounds. These compounds were identified as caffeic acid (CA) and (-)-epicatechin 3-gallate (ECG) based on spectroscopic analyses and comparison with previously published data. Using broth microdilution method, both ECG and CA had demonstrated significant minimum inhibitory concentration of 15.6 and 31.3 μg/mL respectively, against Pseudomonas aeruginosa. Time-kill assessment of ECG and CA displayed bactericidal effect on P. aeruginosa cells.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Perumal S,Mahmud R,Ramanathan Sdoi
10.1080/14786419.2014.999242subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1766-9issue
18eissn
1478-6419issn
1478-6427journal_volume
29pub_type
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