Abstract:
:The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate (1), together with a known alkaloid butyl 1H-imidazole-4-carboxylate (2) was obtained from the fermentation products of this strain, the structures of compounds 1 and 2 were determined by their detailed analysis of 1 D, 2 D NMR and HR-ESI-MS data, along with literature data analysis. Compounds 1 and 2 were evaluated for their antimicrobial activity with MIC (minimum inhibitory concentration) values ranging from 8 to 256 μg · mL-1 against Helicobacter pylori, Klebsiella Pneumonia, Staphylococcus aureus and Enterococcus faecalis.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Chen MH,Lian YY,Fang DS,Chen L,Jia J,Zhang WL,Lin R,Xie Y,Bi HK,Jiang Hdoi
10.1080/14786419.2019.1689498subject
Has Abstractpub_date
2019-11-15 00:00:00pages
1-7eissn
1478-6419issn
1478-6427pub_type
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