A nor-diterpene from Salvia sahendica leaves.

Abstract:

:Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Mofidi Tabatabaei S,Salehi P,Moridi Farimani M,Neuburger M,De Mieri M,Hamburger M,Nejad-Ebrahimi S

doi

10.1080/14786419.2017.1290619

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1758-1765

issue

15

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

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