Abstract:
:Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Mofidi Tabatabaei S,Salehi P,Moridi Farimani M,Neuburger M,De Mieri M,Hamburger M,Nejad-Ebrahimi Sdoi
10.1080/14786419.2017.1290619subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1758-1765issue
15eissn
1478-6419issn
1478-6427journal_volume
31pub_type
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