Abstract:
:The chemical investigation of whole plants Euphorbia stracheyi Boiss from China led to the isolation of one new ent-kaurane diterpene, ent-Kaurane-16β,17,19-triol-3-one (1), along with three known ent-kaurane diterpenoids (2-4) as ent-Kaurane-3α,16β,17-triol (2),ent-16S,17-dihydroxy-kaurane-3-one (3) and ent-3S,16S,17-trihydroxy-kaurane-2-one (4). Their structures were elucidated by extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. Compound 2 was a new natural product and firstly isolated from nature, while compounds (3-4) were isolated from E. stracheyi for the first time. All isolated compounds (1-4) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Liu T,Liang Q,Xiong NN,Dai LF,Wang JM,Ji XH,Xu WHdoi
10.1080/14786419.2016.1222385subject
Has Abstractpub_date
2017-01-01 00:00:00pages
233-238issue
2eissn
1478-6419issn
1478-6427journal_volume
31pub_type
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