Novel derivatives of monascus pigment having a high CETP inhibitory activity.

Abstract:

:The cholesteryl ester transfer protein (CETP), inhibition of which assists in maintaining a high level of high-density lipoprotein cholesterol in the blood, is a target for anti-atherosclerosis treatments. Orange monascus pigment was produced by a Monascus species in a 5 L jar fermenter and various derivative compounds were synthesised by incorporating 19 different L-amino acids into the orange pigment. Among them, the L-Thr and L-Tyr derivatives exhibited high inhibitory activities against the CETP reaction. The inhibitory activities of the L-Thr and L-Tyr derivatives increased in a dose-dependent manner, resulting in IC50 values of 1.0 and 2.3 μM, respectively. When CETP reactions in the presence of the derivatives were performed, the inhibition modes of the L-Thr and L-Tyr derivatives were non-competitive with inhibition constant (Ki) values of 2.7 and 4.3 μM, respectively.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Jang H,Choe D,Shin CS

doi

10.1080/14786419.2014.905561

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

1427-31

issue

18

eissn

1478-6419

issn

1478-6427

journal_volume

28

pub_type

杂志文章
  • Acrepyrone A, a new γ-pyrone derivative from an endophytic fungus, Acremonium citrinum SS-g13.

    abstract::A new γ-pyrone derivative, acrepyrone A (1), and three known sorbicillinoids, trichodimerol (2), dihydrotrichodimerol (3) and tetrahydrotrichodimerol (4) were isolated from an endophytic fungus, Acremonium citrinum SS-g13, harboured in the roots of the Chinese medicinal plant Fructus mori. Their structures were determ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1548462

    authors: Peng XP,Li G,Ji LX,Li YX,Lou HX

    更新日期:2020-04-01 00:00:00

  • Synthesis of C17-[5-methyl-1,3]-oxazoles by N-propargylation of triterpenic acids and evaluation of their cytotoxic activity.

    abstract::A series of unexpected triterpenic C17-[5-methyl-1,3]-oxazoles along with targeted N-propargylamides was synthesized by an interaction of acid chlorides with propargylamine hydrochloride. We proposed that the formation of methyl oxazole passes through an alternative pathway by the participation of the terminal alkyne ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1744139

    authors: Khusnutdinova EF,Petrova AV,Lobov AN,Kukovinets OS,Baev DS,Kazakova OB

    更新日期:2020-03-28 00:00:00

  • Podophyllotoxin and other aryltetralin lignans from Eriope latifolia and Eriope blanchetii.

    abstract::Phytochemical investigation of the aerial parts of Eriope blanchetii and E. latifolia (Lamiaceae) yielded podophyllotoxin, as well as the aryltetralin lignans α- and β-peltatin and yatein. Oleanolic, ursolic and epikatonic acids were also isolated. This is the first occurrence of podophyllotoxin in the family. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410902809500

    authors: Santos EO,Lima LS,David JM,Martins LC,Guedes ML,David JP

    更新日期:2011-09-01 00:00:00

  • Acetylenic thiophenes from the roots of Escinops ellenbeckii from Ethiopia.

    abstract::The hexane fraction from the roots of Echinops ellenbeckii O. Hoffm. from Ethiopia yielded seven acetylenic thiophenes of which five compounds (1, 3, 4, 6, 7) are reported for the first time in this species: the monothiophenes 5-(penta-1,3-diynyl)-2-(but-3-en-1-ynyl)-thiophene (1), 5-(penta-1,3-diynyl)-2-(4-acetoxy-bu...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/1478641042000301711

    authors: Hymete A,Rohloff J,Kjøsen H,Iversen TH

    更新日期:2005-12-01 00:00:00

  • A new lupane-type triterpenoid fatty acid ester and other isolates from Ophiorrhiza shendurunii.

    abstract::A new pentacyclic triterpenoid fatty acid ester, lupan-20-ol-3(β)-yl hexadecanoate (1), together with lupan-20-ol-3(β)-yl acetate (2), olean-18-en-3(β)-yl hexadecanoate (3), dotriacontanoic acid (4), stigmasterol (5), rubiadin (6), nonadecanoic acid (7), palmitic acid (8) and camptothecin (9) were isolated from the he...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1160232

    authors: Rajan R,Venkataraman R,Baby S

    更新日期:2016-10-01 00:00:00

  • New labdane diterpenes from Solidago canadensis.

    abstract::The ethanol extract of roots of Solidago canadensis yielded eight labdane-type diterpenes. Five of those were new natural compounds (9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3a), 13-epi-9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3b), 15,16-epoxy-labdane-7,13-diene-6,16-dione (5), 15-ethoxy-9,13,15,16-bisepoxy-...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.565005

    authors: Wangensteen H,Phan TT,Rise F,Halvorsen TG,Malterud KE

    更新日期:2012-01-01 00:00:00

  • Histochemical investigation of Cochlospermum regium (Schrank) Pilg. leaves and chemical composition of its essential oil.

    abstract::Essential oil from Cochlospermum regium (Schrank) Pilg. leaves (CR-EO) has been extracted by hydrodistillation; we analysed the CR-EO by gas chromatography coupled with mass spectrometry. We also conducted histochemical analysis on cross-sections of the central vein of young and adult leaves. A total of 32 compounds w...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2013.879133

    authors: Inácio MC,Paz TA,Bertoni BW,Vieira MA,Marques MO,Pereira AM

    更新日期:2014-01-01 00:00:00

  • A new triterpenoid and other compounds from lichens Cryptothecia faveomaculata Makhija & Patw.

    abstract::Ten compounds (1-10) were purified from the extract of lichens C. faveomaculata, and among these one new triterpenoid, cryptothecin A (1) was characterized through mass spectrometric and 2D NMR spectroscopic analyses. Some of the isolated compounds were assessed for their antimicrobial (1, 6, and 8) and cytotoxic acti...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1648466

    authors: Ngoc Tuan N,Kuo PC,Trung Hieu T,Tuong Vi LN,Tong Hung Q,Dunge LT,Duy Trinh N,Quang Trung N,Cuu Khoa N,Viet Hai H,Thang TD

    更新日期:2019-08-02 00:00:00

  • Hypogymnia tubulosa extracts: chemical profile and biological activities.

    abstract::This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activit...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1375926

    authors: Stojanović G,Zlatanović I,Zrnzević I,Stanković M,Stankov Jovanović V,Zlatković B

    更新日期:2018-11-01 00:00:00

  • Two new compounds from the roots of Myrica rubra.

    abstract::Two new compounds, myrubol (1) and 3-oxo-11α-hydroxyfriedelane (2), were isolated from the roots of Myrica rubra along with eight known compounds (3-10). Their structures were determined through (1)H-NMR and (13)C-NMR spectral data, including 2-D experiments (HMBC, HMQC, (1)H-(1)H COSY and NOESY) and high-resolution m...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.516749

    authors: Li G,Wang D,Xu S

    更新日期:2011-01-01 00:00:00

  • Antiproliferative activity and chemical constituents of Lonchocarpus cultratus (Fabaceae).

    abstract::The aerial parts of L. cultratus were submitted to a phytopharmacological investigation in order to isolate and identify the major secondary metabolites and evaluate its crude extract, fractions and isolated compounds for antiproliferative activity. Seven compounds were isolated and identified as the chalcones 2',4'-d...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1647427

    authors: da Silva Landim EMBM,Ruiz ALTG,de Carvalho JE,Pomini AM,Pastorini LH,Oliveira Santin SM

    更新日期:2019-08-12 00:00:00

  • Antitumour activity of Prosopis cineraria (L.) Druce against Ehrlich ascites carcinoma-induced mice.

    abstract::The antitumour activity of the hydroalcoholic extract of the leaf (PCL) and stem bark (PCB) of Prosopis cineraria (L.) in Swiss albino mice was evaluated against an Ehrlich ascites carcinoma (EAC) tumour model. The activity was assessed using survival time, peritoneal cells, haematological studies, lipid peroxidation,...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.536159

    authors: Robertson S,Narayanan N,Raj Kapoor B

    更新日期:2011-04-01 00:00:00

  • A new phenol glycoside from Physalis angulata.

    abstract::A new phenol glycoside, physanguloside A (1), was isolated from Physalis angulata together with four known compounds. We report herein, for the first time, the presence of compounds 2-5 in the genus Physalis. The structures of all the compounds were established by NMR, IR, UV and HRESIMS spectroscopic analyses, and co...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1269102

    authors: Sun CP,Nie XF,Kang N,Zhao F,Chen LX,Qiu F

    更新日期:2017-05-01 00:00:00

  • Fatty acid composition of seeds of some species of Nepeta L.

    abstract::The fatty acid compositions of Nepeta viscida, N. cilicica, N. crinita, N. nuda ssp. glandulifera and N. aristata were analyzed by GC/MS. The main free fatty acids were found as linolenic acid (49.8-58.5%), linoleic acid (10.9-23.5%), oleic acid (11.5-19.2%), palmitic acid (5.2-6.8%) and stearic acid (2.0-3.7%) and, t...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601129473

    authors: Kiliç T,Dirmenci T,Gören AC

    更新日期:2007-05-01 00:00:00

  • Thai plants from Doi Tung: brine shrimp lethality, antioxidative activity and combination effect with L-ascorbic acid.

    abstract::Methanolic extracts of 18 Thai plants from Doi Tung, the north of Thailand, were examined for brine shrimp lethality and antioxidative activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In brine shrimp lethality, the highly toxic plant extracts were Mitrephora wangii (LC(50) 14.8 µg mL(-1)) and Hydrocotyle jav...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.534469

    authors: Tanamatayarat P,Sotanaphun U,Poobrasert O

    更新日期:2012-01-01 00:00:00

  • Chemical composition, antioxidant activity and cytotoxicity on tumour cells of the essential oil from flowers of Magnolia grandiflora cultivated in Iran.

    abstract::Magnolia grandiflora (Magnoliaceae) is an evergreen tree with fragrant and showy flowers native to southeastern USA but widely cultivated all over the world and used in cosmetics industry in treatment of skin diseases. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultiv...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1303699

    authors: Morshedloo MR,Quassinti L,Bramucci M,Lupidi G,Maggi F

    更新日期:2017-12-01 00:00:00

  • A new insecticidal havanensin-type limonoid from the roots of Trichilia sinensis Bentv.

    abstract::One new havanensin-type limonoid (1) named trisinlin A with two known compounds (4E,8E)-2-[2'-hydroxyhexadecanoyl amino]-4,8-octadecadiene-1,3-diol (2), 9-octadecenoic acid-2',3'-dihydroxypropyl ester (3) were isolated from the roots of Trichilia sinensis. The structure of the new compound was unambiguously determined...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1380016

    authors: Liu SB,Chen HQ,Feng G,Guo ZK,Cai CH,Wang J,Mei WL,Dai HF

    更新日期:2018-12-01 00:00:00

  • Anti-proliferative and pro-apoptotic effects of cinobufagin on human breast cancer MCF-7 cells and its molecular mechanism.

    abstract::Cinobufagin (CBF) is an active ingredient isolated from Venenum Bufonis extracted and dried from the secretory glands of Bufo gargarizans Cantor. The purpose of the study was to investigate the effects and underlying mechanisms of CBF on human breast cancer MCF-7 cells in vitro. Our results showed that CBF exhibited o...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1315575

    authors: Zhu L,Chen Y,Wei C,Yang X,Cheng J,Yang Z,Chen C,Ji Z

    更新日期:2018-02-01 00:00:00

  • A new cyclopeptide alkaloid from Clematis Florida.

    abstract::One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induce...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1809399

    authors: Wu Y,Zhang YF,Zhang HT,Ma XH,Yang NN,Feng SB,Zhong TH,Zhang YH

    更新日期:2020-08-18 00:00:00

  • Salvia x jamensis J. Compton: Trichomes, essential oil constituents and cytotoxic-apoptotic activity.

    abstract::Salvia x jamensis J. Compton is a hybrid between Salvia greggii A. Gray and Salvia microphylla Kunt. In this study, we describe three hair types identified by Scanning Electron Microscopy. In the essential oil of the aerial parts of S. jamensis 56 different compounds were identified. The two main constituents were β-c...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2012.730044

    authors: Fraternale D,Albertini MC,Rudov A,Flamini G,Ricci D,Bisio A,Battistelli M,Accorsi A

    更新日期:2013-01-01 00:00:00

  • One new anthraquinone from marine Streptomyces sp. FX-58.

    abstract::One new anthraquinone, 1,8-dihydroxy-2-ethyl-3-methylanthraquinone (1), together with two known compounds octadecanoic acid (2) and cholest-4-en-3-one (3) was isolated from marine actinomycete Streptomyces sp. FX-58. The structure of 1 was elucidated on the basis of spectroscopic methods, especially, the 2D-NMR spectr...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410600899142

    authors: Huang YF,Tian L,Fu HW,Hua HM,Pei YH

    更新日期:2006-11-01 00:00:00

  • Antioxidant xanthones from Cratoxylum cochinchinense.

    abstract::A new xanthone named cratoxylumxanthone A (1), together with five known compounds: dulcisxanthone B (2), alpha-mangostin (3), beta-mangostin (4), 2-geranyl-1,3,7-trihydroxy-4-(3-methylbut-2-enyl)xanthone (5) and tectochrystin (6), was isolated from Cratoxylum cochinchinense stems. The structure of new compound was cha...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601102033

    authors: Phuwapraisirisan P,Udomchotphruet S,Surapinit S,Tip-Pyang S

    更新日期:2006-12-01 00:00:00

  • Phytochemical, cytotoxic and chemotaxonomic study on Ajuga forrestii Diels (Labiatae).

    abstract::A phytochemical investigation of Ajuga forrestii Diels led to the isolation of 14 compounds, including eight neo-clerodane diterpenes (1-8), two phytoecdysteroids (9, 11), one stigmastane sterol (10) and three iridoid glycosides (12-14). The structures of these compounds were identified by spectroscopic methods and a ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1371161

    authors: Chen T,Diao QY,Yu HZ,Jiao CL,Ruan J

    更新日期:2018-04-01 00:00:00

  • Two new ent-atisanes from the root of Euphorbia fischeriana Steud.

    abstract::Two new ent-atisanes ent-1β,3β,16β,17-tetrahydroxyatisane (1), ent-1β,3α,16β,17-tetrahydroxyatisane (2) together with 11 known diterpenes were isolated from the anti-tumour activity fraction of Euphorbia fischeriana Steud. The compounds were identified by detailed spectroscopic analysis, including extensive 2D-NMR exp...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1045904

    authors: Wang M,Wang Q,Wei Q,Li J,Guo C,Yang B,Kuang H

    更新日期:2016-01-01 00:00:00

  • Mercury in fish products: what's the best for consumers between bluefin tuna and yellowfin tuna?

    abstract::A total of 205 bluefin and yellowfin tuna samples were examined for mercury detection in order to verify possible differences and have a detailed risk assessment of the two tuna species. The results showed significant higher mercury concentration in muscle tissue of bluefin tuna respect yellowfin tuna (p < 0.001) with...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1309538

    authors: Cammilleri G,Vazzana M,Arizza V,Giunta F,Vella A,Lo Dico G,Giaccone V,Giofrè SV,Giangrosso G,Cicero N,Ferrantelli V

    更新日期:2018-02-01 00:00:00

  • A new 20-membered macrolide produced by a marine-derived Micromonospora strain.

    abstract::A new 20-membered macrolide named as levantilide C was isolated from the Micromonospora strain FIM07-0019 recovered from shallow coastal waters near the island of Chiloe, Chile. The chemical structure of levantilide C was elucidated on the basis of one- and two-dimensional NMR analysis. Two known indole derivatives we...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2012.740038

    authors: Fei P,Chuan-Xi W,Yang X,Hong-Lei J,Lu-Jie C,Uribe P,Bull AT,Goodfellow M,Hong J,Yun-Yang L

    更新日期:2013-08-01 00:00:00

  • Isolation of new esters from the stems of Cinnamomum reticulatum Hay.

    abstract::The stems of Cinnamomum reticulatum Hay (Lauraceae) were extracted with hexane and chloroform successively. A series of new esters, including a mixture of 4-hydroxy-3-methoxyphenethyl derivatives, along with two butanolides, isoobtusilactone A and obtusilactone A, two amides, N-trans-feruloylmethoxytyramine and N-cis-...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786411003746476

    authors: Lin IJ,Lo WL,Chia YC,Huang LY,Cham TM,Tseng WS,Yeh YT,Yeh HC,Wang YD,Chen CY

    更新日期:2010-05-01 00:00:00

  • Chemical composition and antimicrobial activities of Perovskia artemisioides Boiss. essential oil.

    abstract::The Perovskia artemisioides Boiss. essential oil obtained by hydrodistillation method of flowers growing wild in the north of Iran. The study led to the identification of 29 compositions by a combination of HP-5 GC-FID and GC-MS analytical techniques. The constituents were identified in P. artemisioides essential oil ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1101694

    authors: Hafez Ghoran S,Azadi B,Hussain H

    更新日期:2016-09-01 00:00:00

  • Antifungal sesquiterpenes with post-harvest anthracnose control effect on bananas from the fungus Fusarium lateritium.

    abstract::To search for antifungal leads, the metabolites of an insect-derived fungus Fusarium lateritium ZMT01 were investigated, providing five sesquiterpenes (1-5), including new molecules microsphaeropsisins D and E (1 and 2). The evaluated antifungal activities in vitro which are higher than the positive control triadimefo...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2021.1872569

    authors: Zhu J,Xiong P,Li Z,Li J,Lin L,Fu X,Huang Y,Xiong Y,Li C

    更新日期:2021-01-15 00:00:00

  • Qualitative analysis of the chemical constituents in Hedyotis diffusa by HPLC-TOF-MS.

    abstract::A high performance liquid chromatography-time-of-flight-mass spectrometry (HPLC-TOF-MS) method was developed for analysing the chemical constituents in Hedyotis diffusa, which is widely used as a traditional Chinese medicine (TCM) in the field of cancer treatment. The compounds were identified either by comparing the ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.537275

    authors: Wang X,Cheng W,Yao X,Guo X

    更新日期:2012-01-01 00:00:00