Abstract:
:Lappaconitine is an important alkaloid of the aconite family and its biological activity is closely related to its structure. Through an X-ray structure analysis of hydrated lappaconitine hydrobromide, which was synthesised by us through a new method, the absolute configuration of lappaconitine was determined: monoclinic, P2(1), a = 10.619(2) A, b = 12.196(3) A, c = 12.282(2) A, beta = 90.87(1) degrees and Z = 2; Flack parameter is -0.0083(0.0046) and S = 0.867. Rings A, B, C, D, E and F, respectively, present boat, chair, envelope, boat, boat and envelope forms. The absolute stereo configuration of lappaconitine was determined as 1S, 4S, 5S, 7S, 8S, 9S, 10S, 11S, 13R, 14S, 16S and 17R.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Sun W,Wang Y,Zhang J,Yu Kdoi
10.1080/14786410902975616subject
Has Abstractpub_date
2009-01-01 00:00:00pages
960-2issue
10eissn
1478-6419issn
1478-6427pii
912365502journal_volume
23pub_type
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