Abstract:
:Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Tang P,Lin HX,Yuan TH,Cui YMdoi
10.1080/14786419.2018.1484459subject
Has Abstractpub_date
2019-12-01 00:00:00pages
3478-3484issue
24eissn
1478-6419issn
1478-6427journal_volume
33pub_type
杂志文章abstract::Phytochemical investigation of the methylenechloride/methanol extract of the aerial parts of Stachys aegyptiaca afforded a new neoclerodane-type diterpene with a new side chain 1, in addition to two known diterpenes 2 and 3 and a known flavonoid glycoside 4. The structures of the compounds were determined by comprehen...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.830217
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abstract::A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-( - )-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the ...
journal_title:Natural product research
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abstract::A new alkaloid, namely laccarin A (1), along with four known alkaloids, laccarin (2), adenosine (3), indole-3-carboxaldehyde (4) and nicotinamide (5), was isolated from the fungus Lactarius subplinthogalus. The structure of laccarin A (1) was established mainly by spectroscopic methods. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001608073
更新日期:2004-04-01 00:00:00
abstract::Marsdenia tinctoria is an indigo producing plant commonly found in Borneo, Malaysia. In this present study, one new flavone kapitone (1) and three known compounds, that is 3,2'-dihydroxyflavone (2), 1-methylcyclobutene (3) and dimethyl isatoate (4) were isolated from the Malaysia Borneo M. tinctoria R. Br. (Apocynacea...
journal_title:Natural product research
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abstract::In this study, the effects of Benzoinum and Styrax on Escherichia coli (E. coli) growth were investigated by microcalorimetry. Using a TAM Air Isothermal Calorimeter, ampoule method, the power-time curves of E. coli growth at 37°C affected by Benzoinum and Styrax were measured. By analysing some quantitative thermokin...
journal_title:Natural product research
pub_type: 杂志文章
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abstract::Two Streptomyces spp. strains responsible for potato common scab infections in Uruguay which do not produce diketopiperazines were identified through whole-genome sequencing, and the virulence factor produced by one of them was isolated and characterized. Phylogenetic analysis showed that both pathogenic strains can b...
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journal_title:Natural product research
pub_type: 杂志文章
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abstract::Extracts obtained from Cyrtocarpa procera Kunth were evaluated to determine their toxicity on Artemia salina Leach. All the extracts showed a significant activity. Bioguided fractionation of these extracts led to the isolation of beta-sitosterol and the identification of 1,3-propyl-dipentadecanoate, 3-hydroxypropyl-9-...
journal_title:Natural product research
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journal_title:Natural product research
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abstract::A new furanodihydrobenzoxanthone, artomandin (1), together with three other flavonoid derivatives, artoindonesianin C, artonol B, and artochamin A, as well as β-sitosterol were isolated from the stem bark of Artocarpus kemando. The structures of these compounds were determined on the basis of spectral evidence. All of...
journal_title:Natural product research
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abstract::The present study has been focused on the extraction of natural pigments from tomato industry waste. At first, different solvents and solvents mixture were compared to determine which one is the best for extracting carotenoids compounds from tomato by-products. A mixture of hexane and acetone gave the highest caroteno...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1226828
更新日期:2017-01-01 00:00:00
abstract::Fuzhuan brick-tea (FBT) is unique for a fungal fermentation stage in its manufacture process and is classified in dark tea. A new acylated flavonol glycoside, kaempferol 3-O-[E-p-coumaroyl-(→2)][α-l-arabinopyranosyl-(1→3)][α-l-rhamnopyranosyl(1→6)]-β-d-glucopyranoside, which was trivially named as camellikaempferoside...
journal_title:Natural product research
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
abstract::This study discusses the similarities and differences between the antioxidant activities of some essential oils: thyme (Thymus vulgaris), basil (Ocimum basilicum), peppermint (Mentha piperita), clove (Caryophyllus aromaticus), summer savory (Satureja hortensis), sage (Salvia hispanica) and lemon (Citrus limon (L.) Bur...
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journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1300796
更新日期:2017-12-01 00:00:00
abstract::GC/FID and GC-MS analysis revealed germacrene D, bicyclogermacrene, α-cadinol and cubenol as major compounds from aril. Germacrene D, bicyclogermacrene, trans-caryophyllene and δ-elemene are major compounds in fruits. Germacrene D, spathulenol, trans-caryophyllene and caryophyllene oxide are major compounds in leaves....
journal_title:Natural product research
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journal_title:Natural product research
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journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.936016
更新日期:2014-01-01 00:00:00
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更新日期:2016-09-01 00:00:00
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journal_title:Natural product research
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更新日期:2014-01-01 00:00:00
abstract::Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were ac...
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更新日期:2020-05-06 00:00:00