Abstract:
:Two Streptomyces spp. strains responsible for potato common scab infections in Uruguay which do not produce diketopiperazines were identified through whole-genome sequencing, and the virulence factor produced by one of them was isolated and characterized. Phylogenetic analysis showed that both pathogenic strains can be identified as S. niveiscabiei, and the structure of the phytotoxin was elucidated as that of the polyketide desmethylmensacarcin using MS and NMR methods. The metabolite is produced in yields of ∼200 mg/L of culture media, induces deep necrotic lesions on potato tubers, stuns root and shoot growth in radish seedlings, and is comparatively more aggressive than thaxtomin A. This is the first time that desmethylmensacarcin, a member of a class of compounds known for their antitumor and antibiotic activity, is associated with phytotoxicity. More importantly, it represents the discovery of a new virulence factor related to potato common scab, an economically-important disease affecting potato production worldwide.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Lapaz MI,López A,Huguet-Tapia JC,Pérez-Baldassari MF,Iglesias C,Loria R,Moyna G,Pianzzola MJdoi
10.1080/14786419.2018.1511554subject
Has Abstractpub_date
2019-10-01 00:00:00pages
2951-2957issue
20eissn
1478-6419issn
1478-6427journal_volume
33pub_type
杂志文章abstract::Six new compounds, including three terpenoids (1-3) and three lignans (4-6), were isolated from the 95% EtOH extract of the twigs of Tripterygium hypoglaucum. Their structures were determined on the basis of extensive spectroscopic analysis. 9'-O-benzoyl-lariciresinol (4) showed weak cytotoxicity against HepG2/Adr cel...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1564297
更新日期:2020-07-01 00:00:00
abstract::The present study was aimed to isolate active constituents from Blumea axillaris (Lam.) DC (Asteraceae) against phytopathogenic fungi. Bioactivity guided fractionation of the successive n-hexane, chloroform and methanol extract led to the isolation of the monoterpene ester (4 R,5S)-4-hydroxy-7-tigloyloxycarvotanaceton...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1833197
更新日期:2020-10-16 00:00:00
abstract::A 70% ethanol extract from the leaves of Rosa davurica showed significant antioxidant activity in both superoxide anion and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging assays. Phytochemical study of this extract resulted in the isolation of eight compounds, including a new flavonoid glycoside. The che...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.811408
更新日期:2013-01-01 00:00:00
abstract::A sesquiterpenoid quinone, epi-ilimaquinone (1), and two sesquiterpene amino quinones, smenospongine (2) and glycinylilimaquinone (3), were isolated from the Fijian marine sponge Hippospongia sp. The structures of these compounds were determined by spectroscopic analysis. Compounds 1 and 3 were reported for the first ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.722086
更新日期:2013-01-01 00:00:00
abstract::The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profile...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701722433
更新日期:2008-01-01 00:00:00
abstract::Phytochemical investigation of the methanolic extract of Vangueria agrestis aerial parts led to the isolation and characterization of four monoterpene rhamnosides, two ursane saponins, and six flavonoid glycosides. Of these constituents, are three undescribed monoterpene glycosides, vangagrestosides A-C. The reported ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1731744
更新日期:2020-02-24 00:00:00
abstract::A new isoflavone glycoside, named 3'-hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside (1) was isolated from the flowers of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep. The structure of compound 1 was characterised by HR-ESI-MS and NMR spectroscopic methods. In radical scavenging activity test...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1655021
更新日期:2019-08-21 00:00:00
abstract::Present research reports the molecular docking analysis of 2019-nCoV inhibition by antiviral compounds from marine natural resources. For this study, the structure of ligand (antiviral compound) and 2019-nCoV main protease (Mpro) was received from the databases of PubChem and Protein Data Bank (PDB), respectively. Mol...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1791115
更新日期:2020-07-09 00:00:00
abstract::The aim of the present study was to study the effect of seeds of Asteracantha longifolia on the sexual behaviour of male albino rats. The ethanolic extract of seeds of A. longifolia was administered to groups of rats in 100, 150 and 200 mg kg⁻¹ doses for a period of 28 days, and the action compared with control rats. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802588493
更新日期:2011-09-01 00:00:00
abstract::Artemisia annua L. is an annual Eurasian desert-steppe plant. The composition of essential oils found in Artemisia annua from Russian (Buryatian) flora was analyzed in this work using gas chromatography mass-spectrometry method. Artemisia ketone, β-selinene, caryophyllene, caryophyllene oxide, germacrene D were the ma...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1548461
更新日期:2020-09-01 00:00:00
abstract::The extent of the microbial contamination of the seventeenth-century wall paintings in the nave of the old Church of the Holy Ascension (Veliki Krčimir, Serbia) was evaluated via newly implemented ATP bioluminescence method, and traditional cultivation-based method, utilising commercially available dip slides. To asse...
journal_title:Natural product research
pub_type: 历史文章,杂志文章
doi:10.1080/14786419.2015.1108975
更新日期:2019-04-01 00:00:00
abstract::Phytochemical investigation of the extracts of the leaves of Siparuna thecaphora (Poepp. et Endl.) A. DC. (Siparunaceae) allowed the isolation of one monoterpene glycoside, named trans-thujane-1α,7-diol 1-O-β-D-glucopyranoside (1) along with rutin, quercetin 3-O-β-D-glucopyranoside and 3,4-dihydroxybenzaldehyde. Their...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.843179
更新日期:2014-01-01 00:00:00
abstract::Alkaloids and phenolic compounds are among the most biologically active natural products from the Jacobaea/Senecio genera (Asteraceae). To isolate original natural products directly from Jacobaea gigantea crude polar extracts, centrifugal partition chromatography (CPC) was used. Previously, we reported the phytochemic...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1493584
更新日期:2019-08-01 00:00:00
abstract::This study was carried out to investigate the biomedicinal potential of aqueous extract (1.25 and 2.5%) of three henna ecotypes (Shahdad, Roodbar and Bam) against Two types of Gram positive and negative bacteria, Staphylococcus aureus (ATCC 25923), Streptococcus agalactiae (ATCC 29933), Bacillus cereus (ATCC 14579), C...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1569006
更新日期:2020-12-01 00:00:00
abstract::The iridoidic composition of Stachys glutinosa L. was examined in comparison with the results obtained in the phytochemical studies on S. corsica Pers. The presence of the known harpagide and acetyl-harpagide were showed together with that of a new di-glycosidic iridoid. The structure of this new compound, the 5-allos...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600636635
更新日期:2006-05-20 00:00:00
abstract::Medicinal plants have been the main remedy to treat various ailments for a long time and nowadays, many drugs have been developed from traditional medicine. This paper reviews some medicinal plants and their main constituents which possess anti-inflammatory activities useful for curing joint inflammation, inflammatory...
journal_title:Natural product research
pub_type: 杂志文章,评审
doi:10.1080/14786419.2015.1062761
更新日期:2016-06-01 00:00:00
abstract::Investigation of the aerial parts of Vernonia leopoldii (Sch. Bip.) Vatke afforded a new lanostane-type triterpene along with known hirsutinolide-type sesquiterpene lactones and flavonoid glycosides, all are identified for the first time in this species. The new compound was identified as lanost-3β, 23S-dihydroxy-22(3...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1062004
更新日期:2016-01-01 00:00:00
abstract::Santolina insularis is a Sardinian endemism that is widely used in traditional medicine. The essential oil was obtained with a yield of 2.7% and is mainly characterized by β-phellandrene (22.6%), myrcene (11.4%) and artemisia ketone (7.6%). The oil significantly reduced NO production without affecting macrophages viab...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1774764
更新日期:2020-06-04 00:00:00
abstract::Oleiferoside B is a triterpenoid monomer compound, mainly isolated from roots of Camellia oleifera Abel, the underlying mechanism of its antitumour is not clear. In the present study, oleiferoside B potently inhibited SMMC-7721 and MCF-7 cells proliferation and cause cells apoptosis. In addition, it activated an autop...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1739039
更新日期:2020-03-18 00:00:00
abstract::A new β-hydroxydihydrochalcone glycoside named ziganin (1) and a new acylated flavonol glycoside named isorhamnetin-3-O-α-L-(2″,3″-di-O-trans-coumaroyl)-rhamnopyranoside) (2), along with two known flavonoid glycosides, a β-hydroxydihydrochalcone glycoside, a hydroxybenzoic acid derivative, a trinorguaiane type sesquit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1062006
更新日期:2016-01-01 00:00:00
abstract::Triterpene saponins in medicinal plants attract scientific attentions for their structural diversity and significant bioactivities. In this work, a high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS/MS) method is used to rapidly s...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1367787
更新日期:2018-04-01 00:00:00
abstract::A new cycloartane triterpene bisdesmoside, soulieoside T (1), and one known compound, oleanolic acid (2), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. Compound 1 was evaluat...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1700509
更新日期:2019-12-10 00:00:00
abstract::Oldenlandia umbellata L., commonly known as 'chay root', belongs to the family Rubiaceae and is one of the unexplored dye-yielding plants. The roots from this plant are the sources of red dye. Extraction protocol and dye characterisation have not been completely studied so far in this plant. Hence, in this article we ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802696635
更新日期:2009-01-01 00:00:00
abstract::Lappaconitine is an important alkaloid of the aconite family and its biological activity is closely related to its structure. Through an X-ray structure analysis of hydrated lappaconitine hydrobromide, which was synthesised by us through a new method, the absolute configuration of lappaconitine was determined: monocli...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410902975616
更新日期:2009-01-01 00:00:00
abstract::Two new chromones, spororrminone A (1, (S)-5-hydroxy-2-methyl-4-oxo-2-((S)-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid) and 2-epi-spororrminone A (2, (R)-5-hydroxy-2-methyl-4-oxo-2-((S)-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid), were isolated from an EtOAc extract of an endolichenic fungal strain Sp...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1610758
更新日期:2020-11-01 00:00:00
abstract::Bioassay guided chemical investigation of the gorgonian Pacifigorgia senta led to the discovery of a new 19-oxygenated steroid, cholesta-5,24-diene-3β,7β,19-triol (1), as well as three known steroids (2-4). The structure of 1 was determined by extensive spectroscopic analysis, including NMR and MS spectra. All of the ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1063055
更新日期:2016-06-01 00:00:00
abstract::The world's rainforests hold untold potential for drug discovery. Rainforest plants are thought to contain evolved defensive active metabolites of greater diversity compared to plants from temperate regions. In recent years, the interest and overall output from pharmaceutical companies on novel antibacterial agents ha...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.537274
更新日期:2011-11-01 00:00:00
abstract::Armoracia rusticana (AR) was tested for antimicrobial and antioxidants power. The compound demonstrated to inhibit fish pathogens such as Vibrio anguillarum, V. harvey, V. alginolyticus, Aeromonas hydrophila, A. salmonicida, Photobacterium damselae subspecie piscicida, Tenacibaculum marinum and Pseudomonas anguillisep...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1517121
更新日期:2020-06-01 00:00:00
abstract::The purpose of this study is to identify the quantity and antibacterial activity of the individual phenolic compounds in Brazilian red propolis. Quantitative analysis of the 12 phenolic compounds in Brazilian red propolis was carried out using reversed-phase high-performance liquid chromatography. The main phenolic co...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.898146
更新日期:2014-01-01 00:00:00
abstract::New sesquiterpene glycoside, cyclodipeptide and piperidine derivative were isolated from Streptomyces sp. YIM 63342. On the basis of spectral data, their structures were determined as 3R, 5R, 6S, 7E, 9R-megastigman-7-en-3,5,6,9-tetrol-9-O-β-D-apiofuranosyl-(1→ 2)-β-D-glucopyranoside (1), cyclo (L-Pro-L-OMet) (2) and (...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.718776
更新日期:2013-01-01 00:00:00