Abstract:
:Bioassay guided chemical investigation of the gorgonian Pacifigorgia senta led to the discovery of a new 19-oxygenated steroid, cholesta-5,24-diene-3β,7β,19-triol (1), as well as three known steroids (2-4). The structure of 1 was determined by extensive spectroscopic analysis, including NMR and MS spectra. All of the compounds exhibited cytotoxicities against HepG2, Hep3B, MCF-7/ADR, PC-3 and HCT-116 cell lines, with the IC50 values ranging from 7.0 to 29.7 μM. It is the first report on the chemical constituents of the coral species P. senta.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Chen M,Han L,Zhang XL,Wang CYdoi
10.1080/14786419.2015.1063055subject
Has Abstractpub_date
2016-06-01 00:00:00pages
1431-5issue
12eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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