Chemical composition of Erycibe schmidtii and antiproliferative activity of scopoletin on immature dendritic cells.

Abstract:

:Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in China. Its bioactive ingredients on RA are still unclear. In this study, twenty compounds including a new caffeoylquinic acid derivative, 3-O-caffeoyl-4-O-syringoylquinic acid methyl ester (16), were isolated from E. schmidtii. Their structures were elucidated by NMR and mass spectroscopic analysis, and comparison with literature data. Seventeen compounds were obtained from this plant for the first time, and ten were first found from the genus Erycibe. Scopoletin (1, 5.0 μM) functionally reduced proliferation level of bone marrow immature dendritic cells (BM-iDCs) more than 50%, relative to vehicle. However, scopoletin (1) exhibited no effect on the phagocytosis or survival of BM-iDCs in vitro.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Ren W,Wang Y,He Q,Zhou Y,Li C,Wang W,Leng X,Zeng T,Zou Q,Li L

doi

10.1080/14786419.2018.1547292

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

2581-2588

issue

18

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

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