Abstract:
:Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in China. Its bioactive ingredients on RA are still unclear. In this study, twenty compounds including a new caffeoylquinic acid derivative, 3-O-caffeoyl-4-O-syringoylquinic acid methyl ester (16), were isolated from E. schmidtii. Their structures were elucidated by NMR and mass spectroscopic analysis, and comparison with literature data. Seventeen compounds were obtained from this plant for the first time, and ten were first found from the genus Erycibe. Scopoletin (1, 5.0 μM) functionally reduced proliferation level of bone marrow immature dendritic cells (BM-iDCs) more than 50%, relative to vehicle. However, scopoletin (1) exhibited no effect on the phagocytosis or survival of BM-iDCs in vitro.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Ren W,Wang Y,He Q,Zhou Y,Li C,Wang W,Leng X,Zeng T,Zou Q,Li Ldoi
10.1080/14786419.2018.1547292subject
Has Abstractpub_date
2020-09-01 00:00:00pages
2581-2588issue
18eissn
1478-6419issn
1478-6427journal_volume
34pub_type
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