Abstract:
:One new naturally occurring quinone, 3',4'-dihydroxy-1,2,6-trimethoxy-[1,1'-biphenyl]-4(1H)-one (1), one new diarylpropane, emarginone A (2), and one new neolignan, emarginone B (3), along with eighteen known compounds have been isolated from the chemical investigation of the EtOAc-soluble fraction of the Vaccinium emarginatum whole plant methanolic extract. The new structures were elucidated by combined analysis of spectroscopic analytical methods and comparison with the literature data obtained from known analogues. In addition, the cytotoxicity of compounds 2, 4, and 14-20 against Du145 and PC-3 prostate cancer cell lines using MTT cell proliferation assay was evaluated. Compounds 2 and 19 showed most potent cytotoxicity against Du145 with IC50 values of 7.53 and 6.63 μg/mL, respectively. Furthermore, compounds 2, 17, and 19 also exhibited significant cytotoxicity against PC-3 with IC50 values ranging from 3.44-6.64 μg/mL.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Tu PC,Liang YC,Kao MC,Chao LK,Tseng MH,Lu TL,Sung PJ,Kuo YHdoi
10.1080/14786419.2019.1655412subject
Has Abstractpub_date
2019-09-09 00:00:00pages
1-9eissn
1478-6419issn
1478-6427pub_type
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