Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer.

abstract：:A simple extraction procedure and HPLC method was developed to analyse the major and minor components of induced phytoalexins of elicited tissues (seeds) of chickpeas (Cicer arietinum L.) and peas (Pisum sativum L.) treated with a biotic elicitor (k-carrageenan) of Hypnea musciformis (red algae) from the Karachi coast...

journal_title：Natural product research

authors： Arman M

更新日期：2011-08-01 00:00:00

abstract：:Three species of the genus Homalium - e.g. Homalium nepalense, Homalium tomentosum and Homalium zeylanicum (Flacourtiaceae) - are recorded in India which are confined to the Eastern Ghat hill ranges. While H. zeylanicum is the IUCN red-listed medium-sized tree, the other two are endangered species of medicinal signifi...

journal_title：Natural product research

authors： Mahapatra AK,Pani SS,Sahoo AK

更新日期：2015-01-01 00:00:00

abstract：:Cardiac glycosides are used for treatment of irregular heartbeats, cardiac arrhythmia and congestive heart failures. In this research, digitoxin as a cardiac glycoside was identified and isolated for the first time in the world from Adonis aestivalis and investigated for its cytotoxic activity against cervical cancer ...

journal_title：Natural product research

authors： Hosseini M,Taherkhani M,Ghorbani Nohooji M

更新日期：2019-03-01 00:00:00

abstract：:Chemical investigation of Trogopterus faeces has led to the isolation of seven flavonoids. Their structures were elucidated by chemical and spectral analyses. In an anticoagulative assay, three kaempferol coumaroyl rhamnosides had significant antithrombin activity. This is the first report on the occurrence of flavono...

journal_title：Natural product research

authors： Yang NY,Tao WW,Duan JA

更新日期：2010-11-01 00:00:00

abstract：:Two new ergosterol derivatives namely, chlamydosterols A [(22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol 6-decanoate] (1) and B [5α,6β,25-trihydroxy-(22E,24R)-ergosta-7,22-dien-3-one] (5) and three known ergosterols: ergosta-7,22-dien-3β-ol (2), ergosta-5,7,22-triene-3β-ol (3), and ergosta-7,22-diene-3β,5α,6β-triol (4) w...

journal_title：Natural product research

authors： Al-Rabia MW,Mohamed GA,Ibrahim SRM,Asfour HZ

更新日期：2020-05-06 00:00:00

abstract：:Evaluation of in vitro standard antioxidant assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis-3 ethylbenzothiozoline-6-sulphonic acid diammonium salt (ABTS+) radical scavenging, lipid peroxidation inhibitory (or thiobarbituric acid formation inhibitory activity) and ferrous ion (Fe+2) chelating acti...

journal_title：Natural product research

authors： Chakraborty K,Raola VK

更新日期：2018-11-01 00:00:00

abstract：:The ethanolic extract of the bulbs of Fritillaria imperialis was subjected to fractionation by solvent-solvent extraction. The nonpolar fraction showed inhibitory activity against prolyl endopeptidase (PEP) (EC.3.4.21.26), a large intracellular enzyme that preferentially hydrolyze proline-containing oligopeptidase at ...

journal_title：Natural product research

authors： Atta-ur-Rahman,Akhtar MN,Choudhary MI,Tsuda Y,Yasin A,Sener B,Parvez M

更新日期：2005-01-01 00:00:00

abstract：:The essential oil composition of the aerial parts of Nepeta erecta Benth. (Family: Lamiaceae) from Uttarakhand, India was analysed by capillary gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 34 constituents were identified representing 94.6% of the oil composition. Oxygenated mono...

journal_title：Natural product research

authors： Bisht DS,Joshi SC,Padalia RC,Mathela CS

更新日期：2012-01-01 00:00:00

abstract：:The hexane fraction from the roots of Echinops ellenbeckii O. Hoffm. from Ethiopia yielded seven acetylenic thiophenes of which five compounds (1, 3, 4, 6, 7) are reported for the first time in this species: the monothiophenes 5-(penta-1,3-diynyl)-2-(but-3-en-1-ynyl)-thiophene (1), 5-(penta-1,3-diynyl)-2-(4-acetoxy-bu...

journal_title：Natural product research

authors： Hymete A,Rohloff J,Kjøsen H,Iversen TH

更新日期：2005-12-01 00:00:00

abstract：:A phytochemical investigation on Lagotis brevituba led to the isolation and characterisation of 11 phenolic compounds: p-hydroxy-benzoic acid 1, methyl 3,4-dihydroxybenzoate 2, vanillic acid 3, protocatechuic acid 4, caffeic acid 5, glucose ester of (E)-ferulic acid 6, p-coumaric acid 7, vanillin 8, diosmetin-7-O-β-d-...

journal_title：Natural product research

authors： Yuan X,Wen H,Cui Y,Fan M,Liu Z,Mei L,Shao Y,Wang Y,Tao Y

更新日期：2017-02-01 00:00:00

abstract：:Pigments synthesised by Chryseobacterium sp. kr6 growing on feather waste were extracted and characterised. The pigment extract was characterised by KOH test, UV-vis, CIELAB colour system, HPLC-DAD-MS, FTIR and its antioxidant capacity was evaluated. A positive bathochromic shift was observed when kr6 colonies or pigm...

journal_title：Natural product research

authors： Jiménez MEP,Pinilla CMB,Rodrigues E,Brandelli A

更新日期：2019-06-01 00:00:00

abstract：:A new cyclopeptide alkaloid, sativanine-M (1), together with known alkaloid nummularine-P have been isolated from the stem bark of Zizyphus sativa and identified by spectral analysis. ...

journal_title：Natural product research

authors： Pandey MB,Singh AK,Singh VP,Pandey VB

更新日期：2008-02-15 00:00:00

abstract：:The subject of this present work is a group of nine historical pictures shot in Palermo by the Sicilian photographer E. Interguglielmi in 1912. They are nine matte-collodion prints mounted on the original cardboard supports and all of them show foxing stains affecting the paper surface. In order to characterise the ch...

journal_title：Natural product research

authors： Modica A,Bruno M,Di Bella M,Alberghina MF,Brai M,Fontana D,Tranchina L

更新日期：2019-04-01 00:00:00

abstract：:The chemical investigation of whole plants Euphorbia stracheyi Boiss from China led to the isolation of one new ent-kaurane diterpene, ent-Kaurane-16β,17,19-triol-3-one (1), along with three known ent-kaurane diterpenoids (2-4) as ent-Kaurane-3α,16β,17-triol (2)，ent-16S,17-dihydroxy-kaurane-3-one (3) and ent-3S,16S,17...

journal_title：Natural product research

authors： Liu T,Liang Q,Xiong NN,Dai LF,Wang JM,Ji XH,Xu WH

更新日期：2017-01-01 00:00:00

abstract：:To date, despite extensive investigations, full understanding of the endocannabinoid system remains elusive; in particular, anandamide cellular uptake is a current controversial topic. An iodo-arylazido probe was synthesized from commercially available azelaic acid monomethyl ester, in order to shed light on the anand...

journal_title：Natural product research

authors： Balas L,Hellal M,Rossi JC,Durand T

更新日期：2005-06-01 00:00:00

abstract：:The stems of Cinnamomum reticulatum Hay (Lauraceae) were extracted with hexane and chloroform successively. A series of new esters, including a mixture of 4-hydroxy-3-methoxyphenethyl derivatives, along with two butanolides, isoobtusilactone A and obtusilactone A, two amides, N-trans-feruloylmethoxytyramine and N-cis-...

journal_title：Natural product research

authors： Lin IJ,Lo WL,Chia YC,Huang LY,Cham TM,Tseng WS,Yeh YT,Yeh HC,Wang YD,Chen CY

更新日期：2010-05-01 00:00:00

abstract：:The objective of this work was to produce and characterise nanoemulsions containing tucumã extract and to evaluate the performance of the nanostructure and the free compound regarding antitumor activity, cytotoxicity, and oxidative metabolism in NB4/APL cells. The nanoemulsions showed adequate physicochemical characte...

journal_title：Natural product research

authors： Copetti PM,Gündel SDS,de Oliveira PSB,Favarin FR,Ramos AP,Pintos FG,Pappis L,Gündel A,Machado AK,Ourique AF,Sagrillo MR

更新日期：2020-12-24 00:00:00

abstract：:A flavanone has been isolated first time from the stem of Bauhinia variegata, and its structure was identified by colour reactions and spectral analysis. In a search for novel anticancer compounds from medicinal plants, the isolated flavanone was tested for cytotoxic activity against 57 human tumour lines, representin...

journal_title：Natural product research

authors： Rajkapoor B,Murugesh N,Rama Krishna D

更新日期：2009-01-01 00:00:00

abstract：:Illicium lanceolatum is a popular aromatic and medicinal plant in China. Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS. The essential oil was dominated by phenylpropenes. The major components were myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%)...

journal_title：Natural product research

authors： Liang J,Huang B,Wang G

更新日期：2012-01-01 00:00:00

abstract：:One new havanensin-type limonoid (1) named trisinlin A with two known compounds (4E,8E)-2-[2'-hydroxyhexadecanoyl amino]-4,8-octadecadiene-1,3-diol (2), 9-octadecenoic acid-2',3'-dihydroxypropyl ester (3) were isolated from the roots of Trichilia sinensis. The structure of the new compound was unambiguously determined...

journal_title：Natural product research

authors： Liu SB,Chen HQ,Feng G,Guo ZK,Cai CH,Wang J,Mei WL,Dai HF

更新日期：2018-12-01 00:00:00

abstract：:Investigation of the roots of Lotus polyphyllos Clarke resulted in the isolation of two new isoflavone derivatives; 4'-O-methylerythrinin C (3) and 4'-O-methyl-2''-hydroxydihydroalpinumisoflavone (4). In addition, the three known isoflavone derivatives 4'-O-methylalpinumisoflavone (1) lupinalbin F (5), 4',7-dimethoxy-...

journal_title：Natural product research

authors： Abdel-Kader MS,Amer ME,Tang S,Kingston DG

更新日期：2006-08-01 00:00:00

abstract：:One novel hexanordammarane glycoside, ginsenoside R(10), was isolated from the leaves and stems of Panax quinquefolium L. as a minor constituent. It is the first time that a hexanordammarane glycoside isolated from the plant of Panax quinquefolium L. Its structure was elucidated as 3-O-β-D-glucopyranosyl-3β, 12β-dihyd...

journal_title：Natural product research

authors： Liu JP,Lu D,Li PY

更新日期：2012-01-01 00:00:00

abstract：:Six sesquiterpenoids and four lignans (1-10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2-4) were first obtained from this genus. All the isola...

journal_title：Natural product research

authors： Long L,Wang L,Qi S,Yang Y,Gao H

更新日期：2020-04-01 00:00:00

abstract：:Investigations were performed on the determination of the main components in Berchemia lineata (L.) DC. (BL) and its metabolism with human liver microsomes (HLM). A total of 35 compounds were detected in BL extracts and 25 of them including 6 naphthopyrones, 10 flavonoids, 2 phenolic acids, 2 phenols, 4 fatty acids an...

journal_title：Natural product research

authors： Jiang X,Chen S,Guo Z,Gu D,Liang X

更新日期：2021-02-01 00:00:00

abstract：:A new eremophilane sesquiterpene was isolated from the roots of Senecio nemorensis. Its structure was established as 10alpha-hydroxy-6beta-propionyloxy-1-oxoeremophila-7(11),8-dieno-12,8-lactone on the basis of spectral analysis. ...

journal_title：Natural product research

authors： Meng FJ,Xiao YN,Zhao RJ,Zhao H,Ma QL,Xie WD

更新日期：2009-01-01 00:00:00

abstract：:The anti-atherogenic potentials of total ginger (Zingiber officinale) extract (TGE) or curcuminoids extracted from turmeric (Curcuma longa), members of family Zingiberaceae, were compared in hypercholesterolaemia. Rabbits were fed either normal or atherogenic diet. The rabbits on atherogenic diet received treatments w...

journal_title：Natural product research

authors： Elseweidy MM,Younis NN,Elswefy SE,Abdallah FR,El-Dahmy SI,Elnagar G,Kassem HM

更新日期：2015-01-01 00:00:00

abstract：:A novel monoterpenoid indole alkaloid, melognine (1) possessing an unprecedented skeleton with a 6/6/5/5/6/6 hexatomic rearranged ring system was isolated from the stems of Melodinus fusiformis. The structure with absolute configuration of 1 was established by extensive spectroscopic analyses and quantum ECD calculati...

journal_title：Natural product research

authors： Zhou J,Du SY,Fang ZY,Feng JH

更新日期：2019-11-01 00:00:00

abstract：:Toxicity of the pesticide carbofuran (CF) can be alleviated by curcumin, if not for its poor bioavailability. Hence, we investigated the effect of a bioavailable curcumin-galactomannan complex (CGM) on CF-induced neurotoxicity in rats in comparison to that of unformulated standard curcumin (CS). The CF (5 mg/kg b.wt/d...

journal_title：Natural product research

authors： E R S,P P B,Nair SS,Maliakel B,Kuttan R,I M K

更新日期：2020-05-01 00:00:00

abstract：:Santolina insularis is a Sardinian endemism that is widely used in traditional medicine. The essential oil was obtained with a yield of 2.7% and is mainly characterized by β-phellandrene (22.6%), myrcene (11.4%) and artemisia ketone (7.6%). The oil significantly reduced NO production without affecting macrophages viab...

journal_title：Natural product research

authors： Alves-Silva JM,Piras A,Porcedda S,Falconieri D,Maxia A,Gonçalves MJ,Cruz MT,Salgueiro L

更新日期：2020-06-04 00:00:00

abstract：:A new hexadienamide derivative named sarmentosamide (1) was identified from the culture of Streptomyces sp. SBI108 isolated from Thai soil under an herb. The structure was elucidated on the basis of spectroscopic data, and the absolute configuration was determined by chemical degradation. ...

journal_title：Natural product research

authors： Kitani S,Tomio A,Srichaisupakit A,Daduang R,Intra B,Panbangred W,Oku N,Igarashi Y,Nihira T

更新日期：2013-01-01 00:00:00